Results 31 to 40 of about 18,940 (249)
Theranostics, 2022 Rationale: Recurrent pregnancy loss (RPL) is a distressing disorder that seriously affects the physical and psychological health of women. RPL is also a sentinel risk marker for future obstetric complications and warrants in-depth investigation. Abnormal
Liling Wang +5 more
semanticscholar +1 more source
Lack of decorin expression by human bladder cancer cells offers new tools in the therapy of urothelial malignancies. [PDF]
PLoS ONE, 2013 Decorin, a multifunctional small leucine-rich extracellular matrix proteoglycan, has been shown to possess potent antitumour activity. However, there is some uncertainty whether different cancer cells express decorin in addition to non-malignant stromal ...
Annele Sainio +7 more
doaj +1 more source
American Journal of Physiology - Cell Physiology, 2022 Decorin is a stromal-derived prototype member of the small leucine-rich proteoglycan gene family. In addition to its functions as a regulator of collagen fibrillogenesis and TGFb activity, soluble decorin acts as a pan-receptor tyrosine kinase (RTK ...
C. Xie +4 more
semanticscholar +1 more source
Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression
Matrix Biology Plus, 2022 Decorin and biglycan are two major small leucine-rich proteoglycans (SLRPs) present in the tendon extracellular matrix that facilitate collagen fibrillogenesis, tissue turnover, and cell signal transduction.
Zakary M. Beach +8 more
doaj +1 more source
Decorin Regulates Collagen Fibrillogenesis During Corneal Wound Healing in Mouse in vivo
Experimental Eye Research, 2022 A characteristic rigid spatial arrangement of collagen fibrils in the stroma is critical for corneal transparency. This unique organization of collagen fibrils in corneal stroma can be impacted by the presence and interactions of proteoglycans and ...
Suneel Gupta +7 more
semanticscholar +1 more source
The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis. [PDF]
PLoS ONE, 2012 Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling. Loss of the dermatan sulfate of decorin leads to an Ehlers-Danlos syndrome characterized by
Oliver Jungmann +8 more
doaj +1 more source
Communications Biology, 2021 Inflammatory breast cancer (IBC) is a clinically distinct and highly aggressive form of breast cancer with rapid onset and a strong propensity to metastasize.
Xiaoding Hu +11 more
semanticscholar +1 more source
Focus on Molecules: Decorin [PDF]
Experimental Eye Research, 2011 Decorin (NM_133507) is a ubiquitous small extracellular proteoglycan. It is a composite molecule ~100kda in size with a protein core and attached GAGs. It was cloned from a human embryonic fibroblast line and named PG40 for its protein core, ~40Kda.
Shoujun, Chen, David E, Birk
openaire +2 more sources
Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells [PDF]
, 2022 The extracellular matrix proteoglycan decorin is well-known for its oncosuppressive activity. Here, decorin expression was examined in human vulva carcinoma tissue samples and in primary and commercial cell lines representing this malignant disease ...
Sakari H. Hietanen +9 more
core +1 more source
Decorin Is a Zn2+ Metalloprotein [PDF]
Journal of Biological Chemistry, 1999 Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by leucine-rich repeat motifs. We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high ...
V W, Yang +4 more
openaire +2 more sources