Results 31 to 40 of about 15,701 (207)

Biological functions of decorin in cancer [PDF]

Chinese Journal of Cancer, 2013
Decorin is a member of the extracellular matrix small leucine-rich proteoglycans family that exists and functions in stromal and epithelial cells. Accumulating evidence suggests that decorin affects the biology of various types of cancer by directly or indirectly targeting the signaling molecules involved in cell growth, survival, metastasis, and ...
Bi, Xiu-Li, Yang, Wancai
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The Role of Decorin and Biglycan Signaling in Tumorigenesis [PDF]

Frontiers in Oncology, 2021
The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in affecting tumor growth and progression. In their soluble forms, decorin and biglycan
Diehl, Valentina, Huber, Lisa Sophie, Trebicka, Jonel, Wygrecka, Malgorzata, Iozzo, Renato V, Schaefer, Liliana   +5 more
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A Novel 110-kDa Receptor Protein is Involved in Endocytic Uptake of Decorin by Human Skin Fibroblasts

The Scientific World Journal, 2006
The small leucine-rich proteoglycan (SLRP) decorin is efficiently internalized by a variety of cultured cells. A 51-kDa protein has previously been described as a receptor mediating endocytosis of decorin and of the structurally related SLRP biglycan ...
David Denis Sofeu Feugaing, Hans Kresse, Robert R. Greb, Martin Götte   +3 more
doaj   +1 more source

Molecular and phenotypic expression of decorin as modulator of angiogenesis in human potentially malignant oral lesions and oral squamous cell carcinomas

Indian Journal of Pathology and Microbiology, 2013
Background: Decorin is an extracellular matrix, multifunctional small proteoglycan molecule in tumor stroma that has been shown to be modulator of angiogenesis.
Seema Nayak, Madhu Mati Goel, Vikram Bhatia, Saumya Chandra, Annu Makker, Sandeep Kumar, Satya Prakash Agrawal, Divya Mehrotra, Srikanta Kumar Rath   +8 more
doaj   +1 more source

An Antimetastatic Role for Decorin in Breast Cancer [PDF]

The American Journal of Pathology, 2008
Decorin, a member of the small leucine-rich proteoglycan gene family, down-regulates members of the ErbB receptor tyrosine kinase family and attenuates their signaling, leading to growth inhibition. We investigated the effects of decorin on the growth of ErbB2-overexpressing mammary carcinoma cells in comparison with AG879, an established ErbB2 kinase ...
Goldoni S, Seidler DG, Heath J, FASSAN, MATTEO, BAFFA, RAFFAELE, Thakur ML, Owens RT, McQuillan DJ, Iozzo RV   +8 more
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Decorin is a novel antagonistic ligand of the Met receptor. [PDF]

, 2009
Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell growth by down-regulating the epidermal growth factor receptor.
Humphries, Ashley, Iozzo, Renato V, Owens, Rick T, McQuillan, David J, Sattar, Sampurna, Nyström, Alexander, Goldoni, Silvia, Ireton, Keith   +7 more
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Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase. [PDF]

PLoS ONE, 2013
Exposure of human skin to solar ultraviolet (UV) irradiation induces matrix metalloproteinase-1 (MMP-1) activity, which degrades type I collagen fibrils. Type I collagen is the most abundant protein in skin and constitutes the majority of skin connective
Yong Li, Wei Xia, Ying Liu, Henriette A Remmer, John Voorhees, Gary J Fisher   +5 more
doaj   +1 more source

Dichotomy of decorin activity on the insulin-like growth factor-I system [PDF]

, 2013
The stromal-specific proteoglycan decorin has emerged in recent years as a critical regulator of tumor initiation and progression. Decorin regulates the biology of various types of cancer by modulating the activity of several receptor tyrosine kinases ...
Neill, Thomas, Iozzo, Renato V., Morrione, Andrea, Morrione|   +3 more
core   +1 more source

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Acta Neuropathologica Communications, 2022
Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App NL-F/NL-F and App NL-G-F/NL-G-F , exhibiting AD-like
Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M. Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C. Saido, Vesna Jelic, Stina Syvänen, Henrik Zetterberg, Bengt Winblad, Jonas Bergquist, Pieter Jelle Visser, Per Nilsson   +24 more
doaj   +1 more source

Affinity of Placental Decorin for Collagen

Bioscience, Biotechnology, and Biochemistry, 2000
Decorin was isolated from 7 M urea extract of bovine placental cotyledons by ion-exchange and hydrophobic chromatography. Decorin and its core protein showed a broad band at about 115 kDa and a single band at 47 kDa, respectively by SDS-PAGE. Anti-decorin core protein antiserum from pig skin was reacted with placental decorin and its core protein in ...
BATBAYAR, Tumurbaatar, NOMURA, Yoshihiro, ISHII, Yasuhiro, SHIRAI, Kunio   +3 more
openaire   +2 more sources