Results 41 to 50 of about 14,247 (218)

Protective Role of Decorin in Primary Hepatocellular Carcinoma

Frontiers in Oncology, 2020
Hepatocellular carcinoma (HCC) represents one of the most frequent type of primary liver cancers. Decorin, a small leucine-rich proteoglycan of the extracellular matrix, represents a powerful tumor cell growth and migration inhibitor by hindering ...
Andrea Reszegi, Zsolt Horváth, Hajnalka Fehér, Barnabás Wichmann, Péter Tátrai, Ilona Kovalszky, Kornélia Baghy   +6 more
doaj   +1 more source

Affinity of Placental Decorin for Collagen

Bioscience, Biotechnology, and Biochemistry, 2000
Decorin was isolated from 7 M urea extract of bovine placental cotyledons by ion-exchange and hydrophobic chromatography. Decorin and its core protein showed a broad band at about 115 kDa and a single band at 47 kDa, respectively by SDS-PAGE. Anti-decorin core protein antiserum from pig skin was reacted with placental decorin and its core protein in ...
BATBAYAR, Tumurbaatar, NOMURA, Yoshihiro, ISHII, Yasuhiro, SHIRAI, Kunio   +3 more
openaire   +2 more sources

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Acta Neuropathologica Communications, 2022
Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App NL-F/NL-F and App NL-G-F/NL-G-F , exhibiting AD-like
Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M. Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C. Saido, Vesna Jelic, Stina Syvänen, Henrik Zetterberg, Bengt Winblad, Jonas Bergquist, Pieter Jelle Visser, Per Nilsson   +24 more
doaj   +1 more source

Binding of tenascin‐X to decorin

FEBS Letters, 2001
Tenascin‐X (TN‐X) is an extracellular matrix protein whose absence results in an alteration of the mechanical properties of connective tissue. To understand the mechanisms of integration of TN‐X in the extracellular matrix, overlay blot assays were performed on skin extracts.
Elefteriou, Florent, Exposito, Jean-Yves, Garrone, Robert, Lethias, Claire   +3 more
openaire   +2 more sources

Immunostaining for VEGF and Decorin Predicts Poor Survival and Recurrence in Canine Soft Tissue Sarcoma

Veterinary Sciences, 2023
The aim of this study was to investigate whether using immunohistochemistry to detect the angiogenic proteins vascular endothelial growth factor (VEGF) and decorin can help predict the risk of local recurrence of, or death from, canine soft tissue ...
Jonathan P. Bray, Matthew R. Perrott, John S. Munday   +2 more
doaj   +1 more source

Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo. [PDF]

PLoS ONE, 2011
Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissues. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the rabbit stroma with adeno-associated virus serotype
Rajiv R Mohan, Jonathan C K Tovey, Ajay Sharma, Gregory S Schultz, John W Cowden, Ashish Tandon   +5 more
doaj   +1 more source

Biosynthesis of the Proteoglycan Decorin [PDF]

European Journal of Biochemistry, 1997
Biosynthesis of decorin was investigated by incubating a rat fibroblast cell line with various radio‐labelled protein and galactosaminoglycan precursors. The following cell‐associated and distinct intermediates were isolated and identified: a pool of non‐glycosylated core protein, two pools of decorin with incomplete chains, one with three sulphated ...
J, Moses, A, Oldberg, E, Eklund, L A, Fransson   +3 more
openaire   +2 more sources

Elucidating Decorin’s role in the preovulatory follicle [PDF]

Journal of Ovarian Research, 2020
Abstract Background DCN (decorin) is a proteoglycan known to be involved in regulating cell proliferation, collagen fibril organization and migration. In our global transcriptome RNA-sequencing approach to systematically identify new ovulation-associated genes, DCN was identified as one of the highly regulated genes.
A. Kedem, K. Ulanenko-Shenkar, Y. Yung, G. M. Yerushalmi, E. Maman, A. Hourvitz   +5 more
openaire   +3 more sources

MT1-MMP-Mediated cleavage of decorin in corneal angiogenesis [PDF]

, 2009
Background/Aims: Decorin has been shown to have antiangiogenic properties. In this study, we evaluate the involvement of membrane type 1-matrix metalloproteinase (MT1-MMP), a proangiogenic enzyme, in decorin cleavage in the cornea.
Chang, JH, Onguchi, T, Kojima, T, Zhou, Z, Azar, DT, Kim, TI, Han, KY, Mimura, T   +7 more
core   +2 more sources

Decorin impeded the advancement of thyroid papillary carcinoma by thwarting the EGFR/ FER/ SHP2 signaling-induced sustenance of early endosomes

Heliyon
Objective: This study explores the inhibition of papillary thyroid carcinoma proliferation by Decorin via the EGFR/SHP2/FER pathway. Method: ology: Thirty-two pairs of papillary thyroid carcinoma tissues and adjacent normal tissues were collected for ...
Yaping Liu, Yunchao Xin, Tianyun Lv, Zhicheng Chang, Gang Xue, Xiaoling Shang   +5 more
doaj   +1 more source