Results 41 to 50 of about 18,940 (249)

Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.

Journal of Sports Science and Medicine, 2022
Resistance exercise (RE) activates cell signaling pathways associated with myostatin. Decorin is located in the extracellular matrix (ECM) and can block the inhibitory effect of myostatin.
D. Willoughby, T. Cardaci, Steven B. Machek, Dylan T. Wilburn, J. Heileson   +4 more
semanticscholar   +1 more source

Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. [PDF]

PLoS ONE, 2012
Cesarean birth rates are rising. Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of ...
Zhiping Wu, Abraham W Aron, Elyse E Macksoud, Renato V Iozzo, Chi-Ming Hai, Beatrice E Lechner   +5 more
doaj   +1 more source

Bone marrow plasma level of decorin may be associated with improved treatment outcomes in a subset of multiple myeloma patients

Journal of the Formosan Medical Association, 2022
Background/purpose: Decorin is a small leucine-rich proteoglycan rich in extracellular matrix with potential antitumor activity. However, the role of decorin in hematological malignancies remains unclear, especially in the case of multiple myeloma (MM ...
Shang-Yi Huang, Hsiu-Hsia Lin, Ming Yao, Jih-Luh Tang, Shang-Ju Wu, Wen-Chien Chou, Szu-Chun Hsu, Bor-Sheng Ko, Hwei-Fang Tien   +8 more
doaj   +1 more source

Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia

Nature Communications, 2021
To elucidate the mechanisms underlying the reduced incidence of brain tumors in children with Neurofibromatosis type 1 (NF1) and asthma, we leverage Nf1 optic pathway glioma (Nf1OPG) mice, human and mouse RNAseq data, and two different experimental ...
Jit Chatterjee, Shilpa Sanapala, Olivia M Cobb, Alice Bewley, Andrea K. Goldstein, Elizabeth C. Cordell, Xia Ge, J. Garbow, M. Holtzman, D. Gutmann   +9 more
semanticscholar   +1 more source

The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma

Biomolecules, 2020
Decorin, the prototype member of the small leucine-rich proteoglycan gene family of extracellular matrix (ECM) proteins, acts as a powerful tumor suppressor by inducing the p21Waf1/Cip1 cyclin-dependent kinase inhibitor, as well as through its ability to
Andrea Reszegi, Zsolt Horváth, Katalin Karászi, Eszter Regős, Victoria Postniková, Péter Tátrai, András Kiss, Zsuzsa Schaff, Ilona Kovalszky, Kornélia Baghy   +9 more
doaj   +1 more source

Decorin Inhibits Dermal Mesenchymal Cell Migration and Induces Scar Formation

Plastic and Reconstructive Surgery, Global Open, 2022
Background:. Variations in skin healing capacities are observed during different murine embryonic developmental stages. Through embryonic day 16 (E16), embryos are able to regenerate dermal architecture following flank skin wounding; however, after E17 ...
Kento Takaya, MD, Noriko Aramaki-Hattori, MD, PhD, Shigeki Sakai, MD, PhD, Keisuke Okabe, MD, PhD, Toru Asou, PD, PhD, Kazuo Kishi, MD, PhD   +5 more
doaj   +1 more source

MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. [PDF]

PLoS ONE, 2015
Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated
Peter Kwan, Jie Ding, Edward E Tredget
doaj   +1 more source

Oncolytic adenovirus-mediated expression of decorin facilitates CAIX-targeting CAR-T therapy against renal cell carcinoma

Molecular Therapy: Oncolytics, 2021
Although chimeric antigen receptor T cell (CAR-T) therapy has been successful for hematological malignancies, it is less effective for solid tumors.
Chen Zhang, Lin Fang, Xueyan Wang, Sen Yuan, Wan-di Li, Weiping Tian, J. Chen, Qi Zhang, Yuxin Zhang, Qing Zhang, Junnian Zheng   +10 more
semanticscholar   +1 more source

Biological functions of decorin in cancer [PDF]

Chinese Journal of Cancer, 2013
Decorin is a member of the extracellular matrix small leucine-rich proteoglycans family that exists and functions in stromal and epithelial cells. Accumulating evidence suggests that decorin affects the biology of various types of cancer by directly or indirectly targeting the signaling molecules involved in cell growth, survival, metastasis, and ...
Bi, Xiu-Li, Yang, Wancai
openaire   +2 more sources

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]

, 2005
Background: Sub- epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Reinhardt Alistair K, Robin J McAnulty, Reinhardt, AK, McAnulty Robin J, Geoffrey J Laurent, Laurent, GJ, Laurent Geoffrey J, Bottoms, SE, Bottoms Stephen E, McAnulty, RJ, Stephen E Bottoms, Alistair K Reinhardt   +11 more
core   +1 more source