Results 41 to 50 of about 15,201 (170)

Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy

Life, 2021
Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization ...
Shermaine W. Y. Low, Tanuja Vaidya, Santosh G. K. Gadde, Thirumalesh B. Mochi, Devesh Kumar, Iris S. Kassem, Deborah M. Costakos, Baseer Ahmad, Swaminathan Sethu, Arkasubhra Ghosh, Shyam S. Chaurasia   +10 more
doaj   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Increased expression of decorin in experimental hydronephrosis [PDF]

, 1997
Increased expression of decorin in experimental hydronephrosis. Transforming growth factor (TGF)-βl is a potential mediator of tubulo-interstitial (TI) fibrosis in the rat unilateral ureteral obstruction (UUO) model.
Levinson, Mark, Diamond, Jonathan R., Kreisberg, Robert, Ricardo, Sharon D.   +3 more
core   +1 more source

Human Metaplastic Breast Carcinoma and Decorin [PDF]

, 2022
Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracellular matrix (ECM).
Sainio A, Jokilammi A, Boström P, Koskivuo I, Elenius K, Järveläinen H, Eigėlienė N   +6 more
core   +1 more source

Promotion of bone cancer pain development by decorin is accompanied by modification of excitatory synaptic molecules in the spinal cord

Molecular Pain, 2019
Bone cancer pain is refractory to currently available clinical treatment owing to its complicated underlying mechanisms. Studies found that extracellular matrix molecules can participate in the regulation of chronic pain.
Huan Wang, Xiaohui Li, Xianqiao Xie, Haiwen Zhao, Yan Gao, Yang Li, Xueqin Xu, Xiaofei Zhang, Changbin Ke, Juying Liu   +9 more
doaj   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Decreased Expression of Decorin and p57(KIP2) Correlates with Poor Survival and Lymphatic Metastasis in Lung Cancer Patients

The International Journal of Biological Markers, 2011
Purpose Decorin, p57(KIP2), and TGF-beta 1 have been investigated as prognostic factors because they appear to be associated with tumorigenesis; however, the effect of decorin and p57(KIP2) in lung cancer remains poorly understood.
Rong Biaoxue, Cai Xiguang, Liu Hua, Ma Hui, Yang Shuanying, Zhang Wei, Shang Wenli, Du Jie   +7 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Oncosuppressive functions of decorin

, 2015
The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble
Neill, Thomas, Schäfer, Liliana, Iozzo, Renato V.   +2 more
core   +1 more source

Biglycan : a multivalent proteoglycan providing structure and signals [PDF]

, 2013
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Schäfer, Liliana, Năstase, Mădălina-Viviana, Young, Marian F.   +2 more
core   +1 more source