Results 41 to 50 of about 15,701 (207)

Protective Role of Decorin in Primary Hepatocellular Carcinoma

Frontiers in Oncology, 2020
Hepatocellular carcinoma (HCC) represents one of the most frequent type of primary liver cancers. Decorin, a small leucine-rich proteoglycan of the extracellular matrix, represents a powerful tumor cell growth and migration inhibitor by hindering ...
Andrea Reszegi, Zsolt Horváth, Hajnalka Fehér, Barnabás Wichmann, Péter Tátrai, Ilona Kovalszky, Kornélia Baghy   +6 more
doaj   +1 more source

Immunostaining for VEGF and Decorin Predicts Poor Survival and Recurrence in Canine Soft Tissue Sarcoma

Veterinary Sciences, 2023
The aim of this study was to investigate whether using immunohistochemistry to detect the angiogenic proteins vascular endothelial growth factor (VEGF) and decorin can help predict the risk of local recurrence of, or death from, canine soft tissue ...
Jonathan P. Bray, Matthew R. Perrott, John S. Munday   +2 more
doaj   +1 more source

Binding of tenascin‐X to decorin

FEBS Letters, 2001
Tenascin‐X (TN‐X) is an extracellular matrix protein whose absence results in an alteration of the mechanical properties of connective tissue. To understand the mechanisms of integration of TN‐X in the extracellular matrix, overlay blot assays were performed on skin extracts.
Elefteriou, Florent, Exposito, Jean-Yves, Garrone, Robert, Lethias, Claire   +3 more
openaire   +2 more sources

Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type

Chinese Journal of Lung Cancer, 2011
Background and objective Decorin is a protein component of the extracellular matrix. It has been proven that decorin plaid an important role in matrix assembly. The protein is also capable of suppressing tumor cell growth.
Yongkai WU, Ting XIAO, Min LI, Ying ZHANG, Yanning GAO, Kelin SUN   +5 more
doaj   +1 more source

Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo. [PDF]

PLoS ONE, 2011
Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissues. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the rabbit stroma with adeno-associated virus serotype
Rajiv R Mohan, Jonathan C K Tovey, Ajay Sharma, Gregory S Schultz, John W Cowden, Ashish Tandon   +5 more
doaj   +1 more source

Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells [PDF]

, 2022
The extracellular matrix proteoglycan decorin is well-known for its oncosuppressive activity. Here, decorin expression was examined in human vulva carcinoma tissue samples and in primary and commercial cell lines representing this malignant disease ...
Sakari H. Hietanen, Pia C. Boström, Anne B. Jokilammi, Katri J. Orte, Marie C. Nyman, Annele O. Sainio, Samu H. Kurki, Klaus Elenius, Seija E. Grenman, Hannu T. Järveläinen   +9 more
core   +1 more source

Decorin impeded the advancement of thyroid papillary carcinoma by thwarting the EGFR/ FER/ SHP2 signaling-induced sustenance of early endosomes

Heliyon
Objective: This study explores the inhibition of papillary thyroid carcinoma proliferation by Decorin via the EGFR/SHP2/FER pathway. Method: ology: Thirty-two pairs of papillary thyroid carcinoma tissues and adjacent normal tissues were collected for ...
Yaping Liu, Yunchao Xin, Tianyun Lv, Zhicheng Chang, Gang Xue, Xiaoling Shang   +5 more
doaj   +1 more source

Myopathy Associated With Dermatan Sulfate-Deficient Decorin and Myostatin in Musculocontractural Ehlers-Danlos Syndrome: A Mouse Model Investigation

Frontiers in Cell and Developmental Biology, 2021
Carbohydrate sulfotransferase 14 (CHST14) encodes dermatan 4-O-sulfotransferase 1, a critical enzyme for dermatan sulfate (DS) biosynthesis. Musculocontractural Ehlers-Danlos syndrome (mcEDS) is associated with biallelic pathogenic variants of CHST14 and
Yuko Nitahara-Kasahara, Yuko Nitahara-Kasahara, Guillermo Posadas-Herrera, Shuji Mizumoto, Aki Nakamura-Takahashi, Yukiko U. Inoue, Takayoshi Inoue, Yoshihiro Nomura, Shin’ichi Takeda, Shuhei Yamada, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Takashi Okada   +14 more
doaj   +1 more source

Biosynthesis of the Proteoglycan Decorin [PDF]

European Journal of Biochemistry, 1997
Biosynthesis of decorin was investigated by incubating a rat fibroblast cell line with various radio‐labelled protein and galactosaminoglycan precursors. The following cell‐associated and distinct intermediates were isolated and identified: a pool of non‐glycosylated core protein, two pools of decorin with incomplete chains, one with three sulphated ...
J, Moses, A, Oldberg, E, Eklund, L A, Fransson   +3 more
openaire   +2 more sources

Decorin knockdown affects the gene expression profile of adhesion, growth and extracellular matrix metabolism in C-28/I2 chondrocytes.

PLoS ONE, 2020
Decorin is a member of small leucine-rich proteoglycan family, which is involved in multiple biological functions mainly as a structural and signaling molecule, and disturbances in its own metabolism plays a crucial role in the pathogenesis of ...
Mengying Wang, Zhengzheng Li, Meng Zhang, Hui Wang, Ying Zhang, Yiping Feng, Yinan Liu, Jinghong Chen   +7 more
doaj   +1 more source