Results 61 to 70 of about 15,701 (207)

Decorin, a growth hormone-regulated protein in humans

, 2018
Context: Growth hormone (GH) stimulates connective tissue and muscle growth, an effect that is potentiated by testosterone. Decorin, a myokine and a connective tissue protein, stimulates connective tissue accretion and muscle hypertrophy.
McLean, Mark (R14882), Neha Bahl, Vita Birzniece, Bahl, Neha (R18861), Ho, Ken K., Birzniece, Vita (R17524), Mark McLean, Stone, Glenn (R17131), Ken K Y Ho, Glenn Stone   +9 more
core   +1 more source

Decreased Expression of Decorin and p57(KIP2) Correlates with Poor Survival and Lymphatic Metastasis in Lung Cancer Patients

The International Journal of Biological Markers, 2011
Purpose Decorin, p57(KIP2), and TGF-beta 1 have been investigated as prognostic factors because they appear to be associated with tumorigenesis; however, the effect of decorin and p57(KIP2) in lung cancer remains poorly understood.
Rong Biaoxue, Cai Xiguang, Liu Hua, Ma Hui, Yang Shuanying, Zhang Wei, Shang Wenli, Du Jie   +7 more
doaj   +1 more source

Engineering an artificial trachea: Quantitative benchmarks and modular strategies for mechanics, epithelialization, and vascular integration

FlexMat, EarlyView.
In this work, we first examine the limitations of surgical repair and stenting, including migration, granulation, mucus plugging, and infection. We then translate these failures into engineering constraints involving geometry, mechanics, fixation, degradation, junctional stress, and remodeling.
Yiwei Xu, Hanqing Dai, Qianwang Ye, Wanlu Zhang, Na Wang, Lei Xiong, Ruiqian Guo   +6 more
wiley   +1 more source

Morphometric quantification of CNV from different time points in rabbit eyes receiving AAV5+/−decorin.

, 2013
Data was collected after day 5 (early), 10 (mid), and 14 (late) of VEGF implantation from the control (no decorin-delivered) and decorin-delivered rabbit corneas.
Gregory S. Schultz (324377), Ajay Sharma (48991), John W. Cowden (341533), Ashish Tandon (341534), Jonathan C. K. Tovey (341532), Rajiv R. Mohan (48994)   +5 more
core   +1 more source

Elucidating Decorin’s role in the preovulatory follicle [PDF]

Journal of Ovarian Research, 2020
Abstract Background DCN (decorin) is a proteoglycan known to be involved in regulating cell proliferation, collagen fibril organization and migration. In our global transcriptome RNA-sequencing approach to systematically identify new ovulation-associated genes, DCN was identified as one of the highly regulated genes.
A. Kedem, K. Ulanenko-Shenkar, Y. Yung, G. M. Yerushalmi, E. Maman, A. Hourvitz   +5 more
openaire   +3 more sources

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes

Bioengineering
During corneal wound healing, transforming growth factor-beta 1 (TGF-β1) causes differentiation of quiescent keratocytes into myofibroblasts. Decorin has been investigated as a promising anti-fibrotic therapeutic for corneal healing due to its ...
Nathaniel S. Tjahjono, Divya Subramanian, Tarik Z. Shihabeddin, Hudson D. Hicks, Victor D. Varner, W. Matthew Petroll, David W. Schmidtke   +6 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Collagen Phagocytosis by Fibroblasts Is Regulated by Decorin [PDF]

Journal of Biological Chemistry, 2005
Decorin is a small, leucine-rich proteoglycan that binds to collagen and regulates fibrillogenesis. We hypothesized that decorin binding to collagen inhibits phagocytosis of collagen fibrils. To determine the effects of decorin on collagen degradation, we analyzed phagocytosis of collagen and collagen/decorin-coated fluorescent beads by Rat-2 and ...
Vinay M, Bhide, Carol A, Laschinger, Pamela D, Arora, Wilson, Lee, Lari, Hakkinen, Hannu, Larjava, Jaro, Sodek, Christopher A, McCulloch   +7 more
openaire   +2 more sources

Induktion der Decorin-Synthese in Endothelzellen durch Wechselwirkung mit Fibroblasten

, 2003
Decorin ist ein multifunktionelles Proteoglykan, das an einer Vielzahl von physiologischen Prozessen beteiligt ist und das von Endothelzellen bei der entzündungsbedingten Angiogenese gebildet wird.
Strazynski, M. (Marco)
core   +2 more sources