Results 61 to 70 of about 18,940 (249)

Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis

Matrix Biology, 2020
The tumor microenvironment encompasses a complex cellular network that includes cancer-associated fibroblasts, inflammatory cells, neo-vessels, and an extracellular matrix enriched in angiogenic growth factors.
Liping Mao, Jinxue Yang, J. Yue, Yang Chen, Hongrui Zhou, Dongdong Fan, QiuHua Zhang, Simone Buraschi, R. Iozzo, Xiuli Bi   +9 more
semanticscholar   +1 more source

Down-Regulation of the Proteoglycan Decorin Fills in the Tumor-Promoting Phenotype of Ionizing Radiation-Induced Senescent Human Breast Stromal Fibroblasts

Cancers, 2021
Simple Summary Ionizing radiation (a typical remedy for breast cancer) results in the premature senescence of the adjacent to the neoplastic cells stromal fibroblasts.
E. Mavrogonatou, A. Papadopoulou, Asimina Fotopoulou, Stathis Tsimelis, Heba Bassiony, A. Yiacoumettis, Petros N Panagiotou, H. Pratsinis, D. Kletsas   +8 more
semanticscholar   +1 more source

Decorin Regulates Cartilage Pericellular Matrix Micromechanobiology

Matrix Biology, 2020
In cartilage tissue engineering, one key challenge is for regenerative tissue to recapitulate the biomechanical functions of native cartilage while maintaining normal mechanosensitive activities of chondrocytes.
Daphney Chery, B. Han, Ying Zhou, Chao Wang, Sheila Adams, P. Chandrasekaran, B. Kwok, S. Heo, M. Enomoto-Iwamoto, X. L. Lu, Dehan Kong, Renato V. Iozzo, David E. Birk, Robert L. Mauck, Lin Han   +14 more
semanticscholar   +1 more source

Affinity of Placental Decorin for Collagen

Bioscience, Biotechnology, and Biochemistry, 2000
Decorin was isolated from 7 M urea extract of bovine placental cotyledons by ion-exchange and hydrophobic chromatography. Decorin and its core protein showed a broad band at about 115 kDa and a single band at 47 kDa, respectively by SDS-PAGE. Anti-decorin core protein antiserum from pig skin was reacted with placental decorin and its core protein in ...
BATBAYAR, Tumurbaatar, NOMURA, Yoshihiro, ISHII, Yasuhiro, SHIRAI, Kunio   +3 more
openaire   +2 more sources

Decorin Mediates Cartilage Matrix Degeneration and Fibrillation in Post-Traumatic Osteoarthritis

Arthritis & Rheumatology, 2020
To elucidate the role of decorin, a small leucine‐rich proteoglycan, in the degradation of cartilage matrix during the progression of post‐traumatic osteoarthritis (OA).
Qing Li, B. Han, Chao Wang, W. Tong, Yulong Wei, Wei-ju Tseng, Lin Han, X. Liu, M. Enomoto-Iwamoto, Robert L. Mauck, L. Qin, Renato V. Iozzo, David E. Birk, Lin Han   +13 more
semanticscholar   +1 more source

Binding of tenascin‐X to decorin

FEBS Letters, 2001
Tenascin‐X (TN‐X) is an extracellular matrix protein whose absence results in an alteration of the mechanical properties of connective tissue. To understand the mechanisms of integration of TN‐X in the extracellular matrix, overlay blot assays were performed on skin extracts.
Elefteriou, Florent, Exposito, Jean-Yves, Garrone, Robert, Lethias, Claire   +3 more
openaire   +2 more sources

Immunostaining for VEGF and Decorin Predicts Poor Survival and Recurrence in Canine Soft Tissue Sarcoma

Veterinary Sciences, 2023
The aim of this study was to investigate whether using immunohistochemistry to detect the angiogenic proteins vascular endothelial growth factor (VEGF) and decorin can help predict the risk of local recurrence of, or death from, canine soft tissue ...
Jonathan P. Bray, Matthew R. Perrott, John S. Munday   +2 more
doaj   +1 more source

Anti-fibrotic Effect of Decorin in Peritoneal Dialysis [PDF]

, 2020
Objectives: Progressive peritoneal fibrosis is a common complication in patients on long‐term peritoneal dialysis (PD), and PD‐associated peritonitis is an important exacerbating factor for peritoneal fibrosis.
Yung, SSY, Zhang, Q, Jiang, N, Chan, DTM, Chau, KM   +4 more
core   +1 more source

Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo. [PDF]

PLoS ONE, 2011
Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissues. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the rabbit stroma with adeno-associated virus serotype
Rajiv R Mohan, Jonathan C K Tovey, Ajay Sharma, Gregory S Schultz, John W Cowden, Ashish Tandon   +5 more
doaj   +1 more source

Decorin the anti-fibrotic proteoglycan and its progression in therapy.

American Journal of Physiology - Cell Physiology
Fibrosis, which underlies numerous chronic diseases, is characterized by excessive extracellular matrix (ECM) accumulation, resulting in disrupted tissue architecture.
Kornélia Baghy, Helga Szakadáti, Ilona Kovalszky   +2 more
semanticscholar   +1 more source