Results 81 to 90 of about 15,701 (207)

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, Volume 13, Issue 56, 9 October 2026.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Decorin Modulates Fibrin Assembly and Structure [PDF]

Journal of Biological Chemistry, 2006
Emerging evidence indicates that fibrin clotting is regulated by different external factors. We demonstrated recently that decorin, a regulator of collagen fibrillogenesis and transforming growth factor-beta activity, binds to the D regions of fibrinogen (Dugan, T.A., Yang, V. W.-C., McQuillan, D.J., and Höök, M. (2003) J. Biol. Chem. 278, 13655-13662).
Tracey A, Dugan, Vivian W-C, Yang, David J, McQuillan, Magnus, Höök   +3 more
openaire   +2 more sources

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Catabolism of aggrecan, decorin and biglycan in tendon [PDF]

Biochemical Journal, 2000
We have examined the catabolism of the proteoglycans aggrecan, decorin and biglycan in fresh tendon samples and in explant cultures of tissue from the tensional and compressed regions of young and mature bovine tendons. A panel of well-characterized antibodies that recognize glycosaminoglycan or protein (linear or neoepitope) sequences was used to ...
S G, Rees, C R, Flannery, C B, Little, C E, Hughes, B, Caterson, C M, Dent   +5 more
openaire   +2 more sources

Decorin promotes robust axon growth on inhibitory CSPGs and myelin via a direct effect on neurons

Neurobiology of Disease, 2008
Inhibitory chondroitin sulfate proteoglycans (CSPGs) and myelin-associated molecules are major impediments to axon regeneration within the adult central nervous system (CNS).
Kenneth Minor, Xiufeng Tang, Genevieve Kahrilas, Simon J. Archibald, Jeannette E. Davies, Stephen J. Davies   +5 more
doaj   +1 more source

Exercise Modulates the Osteoimmune Axis: Myokine‐Mediated Mechanisms in Diabetic Bone Disease

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 7, October 2026.
Exercise activates skeletal muscle to release myokines (irisin, acute IL‐6, IL‐15 and BAIBA) and suppress myostatin, which may help counteract T2DM‐induced hyperglycemia, AGE accumulation, chronic inflammation and osteoimmune imbalance, potentially contributing to improved bone quality and reduced fracture risk.
Chao Wu, Jun Zou, Yu Yuan
wiley   +1 more source

Decorin levels and cardiometabolic function after endurance exercise

Frontiers in Physiology
IntroductionDecorin is secreted from myotubes in response to exercise and plays a vital role in repairing and regenerate skeletal and cardiac muscle.
Antônio Alves de Fontes-Junior, Cesar Augustus Zocoler de Sousa, Leandro Barbosa de Oliveira, Ana Paula Renno Sierra, Maria Fernanda Cury-Boaventura   +4 more
doaj   +1 more source

Role of Triceps Muscle Fiber‐Specific Myokines in Pancreatic β‐Cell Protection: Implications for Type 2 Diabetes: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Type 2 diabetes (T2D) is a major global health challenge, primarily driven by insulin resistance and progressive β‐cell dysfunction aggravated by chronic low‐grade inflammation. Skeletal muscle has emerged as a pivotal endocrine organ through the secretion of myokines, which exert systemic metabolic and immunomodulatory ...
Christian Tague, Dujardin Makeda, Hermann Yokolo, Joshua Ekouo   +3 more
wiley   +1 more source

MT1-MMP-Mediated cleavage of decorin in corneal angiogenesis

, 2009
Background/Aims: Decorin has been shown to have antiangiogenic properties. In this study, we evaluate the involvement of membrane type 1-matrix metalloproteinase (MT1-MMP), a proangiogenic enzyme, in decorin cleavage in the cornea.
Chang, JH, Onguchi, T, Kojima, T, Zhou, Z, Azar, DT, Kim, TI, Han, KY, Mimura, T   +7 more
core   +1 more source

Increased expression of decorin in experimental hydronephrosis

Kidney International, 1997
Transforming growth factor (TGF)-beta1 is a potential mediator of tubulointerstitial (TI) fibrosis in the rat unilateral ureteral obstruction (UUO) model. Decorin is a protein composed of a core protein and a chondroitin sulfate side chain and is capable of inactivating TGF-beta.
Diamond, Jonathan R., Levinson, Mark, Kreisberg, Robert, Ricardo, Sharon D.   +3 more
openaire   +2 more sources