Results 81 to 90 of about 15,201 (170)

Anti-fibrotic Effect of Decorin in Peritoneal Dialysis

, 2020
Objectives: Progressive peritoneal fibrosis is a common complication in patients on long‐term peritoneal dialysis (PD), and PD‐associated peritonitis is an important exacerbating factor for peritoneal fibrosis.
Yung, SSY, Zhang, Q, Jiang, N, Chan, DTM, Chau, KM   +4 more
core   +1 more source

Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker

BMC Pulmonary Medicine, 2017
Background Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnover and tissue homeostasis ...
S.N. Kehlet, C.L. Bager, N. Willumsen, B. Dasgupta, C. Brodmerkel, M. Curran, S. Brix, D.J. Leeming, M. A. Karsdal   +8 more
doaj   +1 more source

Homeostatic Role of Decorin in Right Ventricular Pressure Overload and Pulmonary Hypertension Induced Remodeling

JACC: Basic to Translational Science
Summary: Right ventricular (RV) pressure loading induces RV profibrotic signaling and fibrosis associated with RV dysfunction. RV decorin protein levels are decreased in patients with chronic RV pressure loading.
Yohei Akazawa, MD, PhD, Sriram Vaidyanathan, PhD, Michael Bradley Dewar, MSc, Kana Yazaki, MD, PhD, John Dauz, MSc, Osami Honjo, MD, PhD, Mei Sun, MD, Golam Kabir, MD, Robert P. Jankov, MD, PhD, Scott Patrick Heximer, PhD, Kim A. Connelly, MD, PhD, Mark K. Friedberg, MD, PhD   +11 more
doaj   +1 more source

Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer.

PLoS ONE, 2012
Background and aimDuring prostate development, mesenchymal-epithelial interactions regulate organ growth and differentiation. In adult prostate, stromal-epithelial interactions are important for tissue homeostasis and also play a significant role in ...
Alexander Henke, O Cathal Grace, George R Ashley, Grant D Stewart, Antony C P Riddick, Henry Yeun, Marie O'Donnell, Richard A Anderson, Axel A Thomson   +8 more
doaj   +1 more source

Interaction of heparin cofactor II with biglycan and decorin [PDF]

, 1993
Two small interstitial dermatan sulfate-containing proteoglycans, biglycan and decorin, are present in extracellular matrices of skin, tendon, ligament, and cartilage.

core   +1 more source

Decorin Suppresses Prostate Tumor Growth through Inhibition of Epidermal Growth Factor and Androgen Receptor Pathways

Neoplasia: An International Journal for Oncology Research, 2009
Epidermal growth factor receptor (EGFR) and androgen receptor (AR) pathways play pivotal roles in prostate cancer progression. Therefore, agents with dual-targeting ability may have important therapeutic potential.
Yunping Hu, Haiguo Sun, Rick T. Owens, Jiansheng Wu, Yong Q. Chen, Isabelle M. Berquin, Donna Perry, Joseph T. O'Flaherty, Iris J. Edwards   +8 more
doaj   +1 more source

Lentiviral-Encoded shRNA Silencing of Proteoglycan Decorin Enhances Tendon Repair and Regeneration within a Rat Model

Cell Transplantation, 2013
Injured tendons often heal with scar tissue formation, resulting in uniformly smaller collagen fibrils and poor mechanical properties. The small leucine-rich proteoglycan decorin is well known to regulate fusion of collagen fibrils.
Ping Lu, Guo-Rong Zhang, You-Zhi Cai, Boon Chin Heng, Hao Ren, Lin-Lin Wang, Junfeng Ji, Xiao-Hui Zou, Hong-Wei Ouyang   +8 more
doaj   +1 more source

Decorin, a growth hormone-regulated protein in humans

, 2018
Context: Growth hormone (GH) stimulates connective tissue and muscle growth, an effect that is potentiated by testosterone. Decorin, a myokine and a connective tissue protein, stimulates connective tissue accretion and muscle hypertrophy.
McLean, Mark (R14882), Neha Bahl, Vita Birzniece, Bahl, Neha (R18861), Ho, Ken K., Birzniece, Vita (R17524), Mark McLean, Stone, Glenn (R17131), Ken K Y Ho, Glenn Stone   +9 more
core   +1 more source

Decorin: matrix-based pan-cancer tumor suppressor

Studies have shown that decorin is a potent pan-cancer tumor suppressor that is under-expressed in most cancers. Decorin interacts with receptor tyrosine kinases and functions as a pan-receptor tyrosine kinase inhibitor, thereby suppressing oncogenic ...
Appunni, Sandeep, Zhang, Yanjia, Rubens, Muni, Ramamoorthy, Venkataraghavan, Doke, Mayur, Khosla, Atulya Aman, Saxena, Anshul, Nair, Sudheesh S   +7 more
core   +1 more source

Role of decorin in control of endothelial cell behaviour [PDF]

Angiogenesis is a complex process regulated by co-ordination of extracellular matrix (ECM) and growth factor signalling (via integrins and growth factor receptors respectively).
Fiedler, Lorna
core   +3 more sources