Results 91 to 100 of about 14,247 (218)

Role of decorin in the antimyeloma effects of osteoblasts

Blood, 2008
AbstractBuilding on our previous report that osteoblasts and increased bone formation have a negative impact on myeloma cell growth in a subset of patients, we investigated the role of decorin, the main small leucine-rich proteoglycan (SLRP) expressed and produced by osteoblasts, in the antimyeloma effects of osteoblasts.
Xin, Li, Angela, Pennisi, Shmuel, Yaccoby   +2 more
openaire   +3 more sources

Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice.

, 2012
Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a ...
Yang, Wancai, Renato V. Iozzo (7451198), Nicole M. Pohl (7924214), Andre Balla (7924211), Xiuli Bi (369267), Bi, Xiuli, Iozzo, Renato V, Gou, Yuan, Guzman, Grace, Zhibin Qian (7924199), Yang, George R, Yuan Gou (7924205), Kajdacsy-Balla, Andre, Grace Guzman (7924208), Qian, Zhibin, Wancai Yang (369269), George R. Yang (7924202), Pohl, Nicole M   +17 more
core  

Biglycan : a multivalent proteoglycan providing structure and signals

, 2013
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Schäfer, Liliana, Năstase, Mădălina-Viviana, Young, Marian F.   +2 more
core   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

New insight of some extracellular matrix molecules in beef muscles. Relationships with sensory qualities

Animal, 2016
The aim of this study was to highlight the relationships between decorin, tenascin-X and type XIV collagen, three minor molecules of extracellular matrix (ECM), with some structural parameters of connective tissue and its content in total collagen, its ...
A. Dubost, D. Micol, C. Lethias, A. Listrat   +3 more
doaj   +1 more source

Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury

Molecules, 2020
Search for new cardioprotective therapies is of great importance since no cardioprotective drugs are available on the market. In line with this need, several natural biomolecules have been extensively tested for their potential cardioprotective effects ...
Renáta Gáspár, Kamilla Gömöri, Bernadett Kiss, Ágnes Szántai, János Pálóczi, Zoltán V. Varga, Judit Pipis, Barnabás Váradi, Bence Ágg, Tamás Csont, Péter Ferdinandy, Monika Barteková, Anikó Görbe   +12 more
doaj   +1 more source

Supramolecular Engineering of Fluid Pressure in Filamentous Hybrid Double Network Hydrogels for 3D Chondrocyte Culture

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Inspired by the water‐rich and interconnected biopolymer networks of native load‐bearing tissues, we disclose a connectable design for a hybrid filamentous supramolecular and covalent double network hydrogel generated through in situ photopolymerization.
Ciqing Tong, Ying Chen, Merel L. Janssen, Isabel Sariol, Joeri A. J. Wondergem, Marijn van den Brink, Mertcan Özel, Rob G. H. H. Nelissen, Ingrid Meulenbelt, Doris Heinrich, Yolande F. M. Ramos, Roxanne E. Kieltyka   +11 more
wiley   +1 more source

Decreased Serum Decorin Levels Are Correlated with Aortic Stiffness as Assessed Using Carotid–Femoral Pulse Wave Velocity in Patients with Peritoneal Dialysis

Life
In patients on chronic peritoneal dialysis (PD), aortic stiffness (AS) is a common cardiovascular condition that can predict cardiovascular events and mortality. Decorin is a small leucine-rich proteoglycan that plays a vital role in extracellular matrix
Yahn-Bor Chern, Po-Yu Huang, Yu-Li Lin, Chih-Hsien Wang, Jen-Pi Tsai, Bang-Gee Hsu   +5 more
doaj   +1 more source

The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Osteosarcopenia, defined as the coexistence of osteoporosis and sarcopenia, is an emerging geriatric syndrome linked to the musculoskeletal decline associated with aging. It is correlated with an increased risk of falls, fractures, disability, and mortality.
Javeria Taj, Rabia Zafar, Joshua Ekouo, Ayesha Junaid, Dujardin Makeda, Kinza Latif, Hermann Yokolo   +6 more
wiley   +1 more source

Decorin, a growth hormone-regulated protein in humans

, 2018
Context: Growth hormone (GH) stimulates connective tissue and muscle growth, an effect that is potentiated by testosterone. Decorin, a myokine and a connective tissue protein, stimulates connective tissue accretion and muscle hypertrophy.
McLean, Mark (R14882), Neha Bahl, Vita Birzniece, Bahl, Neha (R18861), Ho, Ken K., Birzniece, Vita (R17524), Mark McLean, Stone, Glenn (R17131), Ken K Y Ho, Glenn Stone   +9 more
core   +1 more source