Results 91 to 100 of about 15,701 (207)

Expression, localization and synthesis of small leucine-rich proteoglycans in developing mouse molar tooth germ

European Journal of Histochemistry, 2020
The gene expression and protein synthesis of small leucine-rich proteoglycans (SLRPs), including decorin, biglycan, fibromodulin, and lumican, was analyzed in the context of the hypothesis that they are closely related to tooth formation.
Angammana Randilini, Kaoru Fujikawa, Shunichi Shibata   +2 more
doaj   +1 more source

Chemotherapy‐Induced Skeletal Muscle Dysfunction and Cognitive Impairment: A Muscle‐Brain Mechanistic Framework With Implications for Exercise Oncology

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%–10% across treatment courses, while chemotherapy‐induced cognitive impairment affects up ...
SoYoung Ahn, Jin‐Soo Kim, Daniel A. Galvao, Dennis R. Taaffe, Dong Hyun Yoon, Carolyn McIntyre, Christelle Schofield, Yoon Jung Chang, Jihee Min, Wook Song, Robert U. Newton   +10 more
wiley   +1 more source

Decorin gene transfer promotes muscle cell differentiation and muscle regeneration.

, 2007
We have shown that decorin, a small leucine-rich proteoglycan, can inhibit transforming growth factor (TGF)-beta1 to prevent fibrous scar formation and improve muscle healing after injury.
Huard, Johnny, Foster, William, Xiao, Xiao, Zhu, Jinghong, Li, Yong, Li, Juan, Sun, Bin, Branca, Maria, Tang, Ying   +8 more
core   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

Representative images showing CNV in rabbit corneas treated AAV5+/−decorin.

, 2013
Lectin (A–F) and collagen type IV (G–L) immunostaining was carried out in corneal tissue sections obtained from AAV5-gfp and AAV5-dcn treated rabbit corneas collected 14 days after VEGF implantation.
Gregory S. Schultz (324377), Ajay Sharma (48991), John W. Cowden (341533), Ashish Tandon (341534), Jonathan C. K. Tovey (341532), Rajiv R. Mohan (48994)   +5 more
core   +1 more source

Decorin treatment of spinal cord injury

Neural Regeneration Research, 2014
The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical ...
Esmaeili, Maryam, Berry, Martin, Logan, Ann, Ahmed, Zubair   +3 more
openaire   +2 more sources

Decreased Serum Decorin Levels Are Correlated with Aortic Stiffness as Assessed Using Carotid–Femoral Pulse Wave Velocity in Patients with Peritoneal Dialysis

Life
In patients on chronic peritoneal dialysis (PD), aortic stiffness (AS) is a common cardiovascular condition that can predict cardiovascular events and mortality. Decorin is a small leucine-rich proteoglycan that plays a vital role in extracellular matrix
Yahn-Bor Chern, Po-Yu Huang, Yu-Li Lin, Chih-Hsien Wang, Jen-Pi Tsai, Bang-Gee Hsu   +5 more
doaj   +1 more source

New insight of some extracellular matrix molecules in beef muscles. Relationships with sensory qualities

Animal, 2016
The aim of this study was to highlight the relationships between decorin, tenascin-X and type XIV collagen, three minor molecules of extracellular matrix (ECM), with some structural parameters of connective tissue and its content in total collagen, its ...
A. Dubost, D. Micol, C. Lethias, A. Listrat   +3 more
doaj   +1 more source

Small Proteoglycans, Big Impact: Decorin, Biglycan, and Asporin in Musculoskeletal Tissue Health and Disease

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT The extracellular matrix (ECM) is a dynamic and information‐rich network that integrates structural support with biochemical and mechanical signaling. Among its key regulatory components are the Small Leucine‐Rich Proteoglycans (SLRPs), a family of matrix molecules that coordinate extracellular architecture with cell signaling.
Alessandra Leone, Zsuzsa Jenei‐Lanzl, Frank Zaucke   +2 more
wiley   +1 more source

PMN cell released proteases cleave decorin in vitro.

, 2013
PMN cells were isolated from peripheral human blood and treated with vehicle or PMA. Conditioned media were collected and incubated with bovine decorin with or without protease inhibitors for 30 minutes. (A) Representative Western blot of decorin: Lane 1:
Wei Xia (349131), Yong Li (15029), Gary J. Fisher (179719), Ying Liu (18461), Henriette A. Remmer (452404), John Voorhees (452405)   +5 more
core   +1 more source