Results 111 to 120 of about 18,940 (249)
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
Matrix Biology, 2017 The small leucine-rich proteoglycans (SLRPs), decorin and biglycan, are key regulators of collagen fibril and matrix assembly. The goal of this work was to elucidate the roles of decorin and biglycan in tendon homeostasis.
K. Robinson +11 more
semanticscholar +1 more source
Modulation of collagen gel contraction by decorin [PDF]
Biochemical Journal, 1996 The small dermatan sulphate protein decorin interacts via its core protein with fibrillar collagens, and its glycosaminoglycan chains were proposed to be capable of self-association. It was therefore of interest to study the role of decorin in the contraction of cell-populated collagen lattices.
K, Bittner +4 more
openaire +2 more sources
Neuroprotection, EarlyView.ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan +3 more
wiley +1 more source
A self-healing hydrogel eye drop for the sustained delivery of decorin to prevent corneal scarring.
Biomaterials, 2019 Scarring/Opacity on the surface of the eye and vascularisation following infectious diseases, inflammation and corneal trauma are often a leading cause of blindness. The 'gold standard' treatment to prevent corneal scarring is the application of amniotic
G. Chouhan +8 more
semanticscholar +1 more source
Allergen-induced asthma is decreased in decorin-deficient mice [PDF]
, 2008 Decorin, is an extracellular matrix proteoglycan with important biological functions. Decorin deficiency affects collagen fibrillogenesis, airway mechanics, airway-parenchymal interdependence, and airway smooth muscle proliferation and apoptosis.
Marchica, Cinzia Loreta, 1984-
core
Interaction of heparin cofactor II with biglycan and decorin [PDF]
, 1993 Two small interstitial dermatan sulfate-containing proteoglycans, biglycan and decorin, are present in extracellular matrices of skin, tendon, ligament, and cartilage.
core +2 more sources
Experimental Physiology, EarlyView.Abstract The association between higher levels of physical activity and lower cancer risk and mortality is well established. However, a causal link is yet to be proven. Recent studies showed a decrease in the proliferation rates of cultured human cancer cells when the human serum used to stimulate them was conditioned by acute exercise. Here, we tested
Carlos M. Soares +7 more
wiley +1 more source
Treating age‐related loss of muscle mass and function: Where should we be focusing?
The Journal of Physiology, EarlyView.Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham +4 more
wiley +1 more source
Decorin Modulates Fibrin Assembly and Structure [PDF]
Journal of Biological Chemistry, 2006 Emerging evidence indicates that fibrin clotting is regulated by different external factors. We demonstrated recently that decorin, a regulator of collagen fibrillogenesis and transforming growth factor-beta activity, binds to the D regions of fibrinogen (Dugan, T.A., Yang, V. W.-C., McQuillan, D.J., and Höök, M. (2003) J. Biol. Chem. 278, 13655-13662).
Tracey A, Dugan +3 more
openaire +2 more sources