Results 121 to 130 of about 18,940 (249)
Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.MSCs exert anti‐inflammatory, anti‐fibrotic and regenerative effects in pulmonary fibrosis. MSC‐derived exosomes reproduce many therapeutic benefits of parental MSCs. Preconditioning and genetic modification improve MSC therapeutic performance. Current preclinical and clinical evidence supports the translational potential of MSC‐based therapies ...
Hajar Nasiri +8 more
wiley +1 more source
Decorin treatment of spinal cord injury
Neural Regeneration Research, 2014 The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical ...
Esmaeili, Maryam +3 more
openaire +2 more sources
Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.ABSTRACT Ageing is a major risk factor for degenerative diseases, including sarcopenia, which is characterized by a progressive loss of skeletal muscle mass and function, frailty, and is associated with increased mortality. Skeletal muscle regeneration relies on muscle stem cells and efficient communication with cellular microenvironment.
Juan Diego Hernández‐Camacho +1 more
wiley +1 more source
Role of decorin in the antimyeloma effects of osteoblasts
Blood, 2008 AbstractBuilding on our previous report that osteoblasts and increased bone formation have a negative impact on myeloma cell growth in a subset of patients, we investigated the role of decorin, the main small leucine-rich proteoglycan (SLRP) expressed and produced by osteoblasts, in the antimyeloma effects of osteoblasts.
Xin, Li +2 more
openaire +3 more sources
Decorin promotes robust axon growth on inhibitory CSPGs and myelin via a direct effect on neurons
Neurobiology of Disease, 2008 Inhibitory chondroitin sulfate proteoglycans (CSPGs) and myelin-associated molecules are major impediments to axon regeneration within the adult central nervous system (CNS).
Kenneth Minor +5 more
doaj +1 more source
European Journal of Histochemistry, 2020 The gene expression and protein synthesis of small leucine-rich proteoglycans (SLRPs), including decorin, biglycan, fibromodulin, and lumican, was analyzed in the context of the hypothesis that they are closely related to tooth formation.
Angammana Randilini +2 more
doaj +1 more source
Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review
Advanced Healthcare Materials, Volume 15, Issue 28, 24 July 2026.Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami +4 more
wiley +1 more source
Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues
Advanced Materials Interfaces, Volume 13, Issue 13, 7 July 2026.ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike +3 more
wiley +1 more source
Decorin as a multivalent therapeutic agent against cancer. [PDF]
, 2016 Decorin is a prototypical small leucine-rich proteoglycan that epitomizes the multifunctional nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine kinases within the target-rich environment of the tumor stroma and tumor
Neill, Thomas +2 more
core +1 more source
Domain structure elucidation of human decorin glycosaminoglycans [PDF]
, 2010 The structure of the GAG (glycosaminoglycan) chain of recombinantly expressed decorin proteoglycan was examined using a combination of intact-chain analysis and domain compositional analysis.
Richard T. Owens +13 more
core +1 more source