Results 101 to 110 of about 15,701 (207)

Anti-fibrotic Effect of Decorin in Peritoneal Dialysis

, 2020
Objectives: Progressive peritoneal fibrosis is a common complication in patients on long‐term peritoneal dialysis (PD), and PD‐associated peritonitis is an important exacerbating factor for peritoneal fibrosis.
Yung, SSY, Zhang, Q, Jiang, N, Chan, DTM, Chau, KM   +4 more
core   +1 more source

Role of decorin in the antimyeloma effects of osteoblasts

Blood, 2008
AbstractBuilding on our previous report that osteoblasts and increased bone formation have a negative impact on myeloma cell growth in a subset of patients, we investigated the role of decorin, the main small leucine-rich proteoglycan (SLRP) expressed and produced by osteoblasts, in the antimyeloma effects of osteoblasts.
Xin, Li, Angela, Pennisi, Shmuel, Yaccoby   +2 more
openaire   +3 more sources

Allergen-induced asthma is decreased in decorin-deficient mice

, 2008
Decorin, is an extracellular matrix proteoglycan with important biological functions. Decorin deficiency affects collagen fibrillogenesis, airway mechanics, airway-parenchymal interdependence, and airway smooth muscle proliferation and apoptosis.
Marchica, Cinzia Loreta, 1984-
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Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker

BMC Pulmonary Medicine, 2017
Background Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnover and tissue homeostasis ...
S.N. Kehlet, C.L. Bager, N. Willumsen, B. Dasgupta, C. Brodmerkel, M. Curran, S. Brix, D.J. Leeming, M. A. Karsdal   +8 more
doaj   +1 more source

Role of decorin in control of endothelial cell behaviour [PDF]

Angiogenesis is a complex process regulated by co-ordination of extracellular matrix (ECM) and growth factor signalling (via integrins and growth factor receptors respectively).
Fiedler, Lorna
core   +4 more sources

Homeostatic Role of Decorin in Right Ventricular Pressure Overload and Pulmonary Hypertension Induced Remodeling

JACC: Basic to Translational Science
Summary: Right ventricular (RV) pressure loading induces RV profibrotic signaling and fibrosis associated with RV dysfunction. RV decorin protein levels are decreased in patients with chronic RV pressure loading.
Yohei Akazawa, MD, PhD, Sriram Vaidyanathan, PhD, Michael Bradley Dewar, MSc, Kana Yazaki, MD, PhD, John Dauz, MSc, Osami Honjo, MD, PhD, Mei Sun, MD, Golam Kabir, MD, Robert P. Jankov, MD, PhD, Scott Patrick Heximer, PhD, Kim A. Connelly, MD, PhD, Mark K. Friedberg, MD, PhD   +11 more
doaj   +1 more source

Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer.

PLoS ONE, 2012
Background and aimDuring prostate development, mesenchymal-epithelial interactions regulate organ growth and differentiation. In adult prostate, stromal-epithelial interactions are important for tissue homeostasis and also play a significant role in ...
Alexander Henke, O Cathal Grace, George R Ashley, Grant D Stewart, Antony C P Riddick, Henry Yeun, Marie O'Donnell, Richard A Anderson, Axel A Thomson   +8 more
doaj   +1 more source

Decorin Suppresses Prostate Tumor Growth through Inhibition of Epidermal Growth Factor and Androgen Receptor Pathways

Neoplasia: An International Journal for Oncology Research, 2009
Epidermal growth factor receptor (EGFR) and androgen receptor (AR) pathways play pivotal roles in prostate cancer progression. Therefore, agents with dual-targeting ability may have important therapeutic potential.
Yunping Hu, Haiguo Sun, Rick T. Owens, Jiansheng Wu, Yong Q. Chen, Isabelle M. Berquin, Donna Perry, Joseph T. O'Flaherty, Iris J. Edwards   +8 more
doaj   +1 more source

Lentiviral-Encoded shRNA Silencing of Proteoglycan Decorin Enhances Tendon Repair and Regeneration within a Rat Model

Cell Transplantation, 2013
Injured tendons often heal with scar tissue formation, resulting in uniformly smaller collagen fibrils and poor mechanical properties. The small leucine-rich proteoglycan decorin is well known to regulate fusion of collagen fibrils.
Ping Lu, Guo-Rong Zhang, You-Zhi Cai, Boon Chin Heng, Hao Ren, Lin-Lin Wang, Junfeng Ji, Xiao-Hui Zou, Hong-Wei Ouyang   +8 more
doaj   +1 more source

Decorin binding protein compositions

, 1998
Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias.
Guo, Betty, Hook, Magnus
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