Results 101 to 110 of about 18,940 (249)

Invasive human bladder cancer cells do not express decorin. [PDF]

, 2013
Analyses were performed on the whole study population and representative images are shown. Asterisks indicate areas populated solely by bladder cancer cells.
Peter J. Boström (470005), Matti Laato (145893), Annele Sainio (470001), Pia Boström (470004), Marie Nyman (470002), Riikka Lund (465685), Hannu Järveläinen (470006), Sanna Vuorikoski (470003)   +7 more
core   +1 more source

Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes

Bioengineering
During corneal wound healing, transforming growth factor-beta 1 (TGF-β1) causes differentiation of quiescent keratocytes into myofibroblasts. Decorin has been investigated as a promising anti-fibrotic therapeutic for corneal healing due to its ...
Nathaniel S. Tjahjono, Divya Subramanian, Tarik Z. Shihabeddin, Hudson D. Hicks, Victor D. Varner, W. Matthew Petroll, David W. Schmidtke   +6 more
doaj   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment

OncoTarget, 2018
Decorin (DCN), an extracellular matrix (ECM) protein, belongs to the small leucine-rich proteoglycan family. As a pluripotent molecule, DCN regulates the bioactivities of cell growth factors and participates in ECM assembly.
Wen Zhang, Y. Ge, Qian Cheng, Qi Zhang, Lin Fang, Junnian Zheng   +5 more
semanticscholar   +1 more source

Catabolism of aggrecan, decorin and biglycan in tendon [PDF]

Biochemical Journal, 2000
We have examined the catabolism of the proteoglycans aggrecan, decorin and biglycan in fresh tendon samples and in explant cultures of tissue from the tensional and compressed regions of young and mature bovine tendons. A panel of well-characterized antibodies that recognize glycosaminoglycan or protein (linear or neoepitope) sequences was used to ...
S G, Rees, C R, Flannery, C B, Little, C E, Hughes, B, Caterson, C M, Dent   +5 more
openaire   +2 more sources

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Decorin production by the human decidua: role in decidual cell maturation.

Molecular human reproduction, 2020
Decidualization involves the proliferation and differentiation of fibroblast-like endometrial stromal cells into epithelioid-shaped and secretory "decidual" cells in response to steroid hormones.
C. Halari, P. Nandi, M. Jeyarajah, S. Renaud, P. Lala   +4 more
semanticscholar   +1 more source

Injectable Decorin/Gellan Gum Hydrogel Encapsulating Adipose-Derived Stem Cells Enhances Anti-Inflammatory Effect in Cartilage Injury via Autophagy Signaling

Cell Transplantation, 2023
Adipose-derived stem cells (ADSCs) are employed as a promising alternative in treating cartilage injury. Regulating the inflammatory “fingerprint” of ADSCs to improve their anti-inflammatory properties could enhance therapy efficiency.
Weiping He, Yu Wu, Zhihong Luo, Genghua Yang, Woquan Ye, Xi Chen, Jianhua Ren, Tangzhao Liang, Zhiqiang Liao, Shihai Jiang, Kun Wang   +10 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Decorin: matrix-based pan-cancer tumor suppressor [PDF]

Studies have shown that decorin is a potent pan-cancer tumor suppressor that is under-expressed in most cancers. Decorin interacts with receptor tyrosine kinases and functions as a pan-receptor tyrosine kinase inhibitor, thereby suppressing oncogenic ...
Appunni, Sandeep, Zhang, Yanjia, Rubens, Muni, Ramamoorthy, Venkataraghavan, Doke, Mayur, Khosla, Atulya Aman, Saxena, Anshul, Nair, Sudheesh S   +7 more
core   +1 more source