Results 141 to 150 of about 18,940 (249)

Decorin binding protein compositions [PDF]

, 1998
Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias.
Guo, Betty, Hook, Magnus
core  

P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration

Journal of Cell Science, 2019
Directional collective cell migration (DCCM) is crucial for morphogenesis and cancer metastasis. P-cadherin (also known as CDH3), which is a cell–cell adhesion protein expressed in carcinoma and aggressive sarcoma cells and associated with poor prognosis,
Maïlys Le Borgne-Rochet, Lucie Angevin, E. Bazellières, Laura Ordas, F. Comunale, E. Denisov, L. Tashireva, V. Perelmuter, I. Bièche, S. Vacher, Cédric Plutoni, M. Séveno, S. Bodin, C. Gauthier-Rouvière   +13 more
semanticscholar   +1 more source

Altered Decorin Biology in Proliferative Vitreoretinopathy:A Mechanistic and Cohort Study [PDF]

, 2018
Purpose: To determine if vitreous levels of the pro-fibrotic cytokine transforming growth factor beta2 (TGF-β2) and its opposing regulator decorin predict subsequent proliferative vitreoretinopathy (PVR) development in patients with rhegmatogenous ...
Begum, Ghazala, Logan, Ann, Blachford, Karen, O'Neill, Jenna, Chaudhary, Rishika, Snead, David R J, Berry, Martin, Blanch, Richard J, Scott, Robert A H   +8 more
core   +1 more source

Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy

Matrix Biology, 2017
Autophagy, a fundamental and evolutionarily-conserved eukaryotic pathway, coordinates a complex balancing act for achieving both nutrient and energetic requirements for proper cellular function and homeostasis.
Simone Buraschi, T. Neill, R. Iozzo
semanticscholar   +1 more source

Human trophoblast stem cell self-renewal and differentiation: Role of decorin

Scientific Reports, 2018
The origin and regulation of stem cells sustaining trophoblast renewal in the human placenta remain unclear. Decorin, a leucine-rich proteoglycan restrains trophoblast proliferation, migration/invasiveness and endovascular differentiation, and local ...
P. Nandi, H. Lim, Eloy Jose Torres-Garcia, P. Lala   +3 more
semanticscholar   +1 more source

The Effect of a Myostatin Antagonist on the Healing of Burn Wounds in Skin. [PDF]

, 2009
The body's remarkable ability to repair itself from damage is both very useful and extremely complex. The wound healing system is characterised by four overlapping phases: hemostasis, inflammation, proliferation, and remodelling.
Fieten, Daniel John
core  

Decorin Suppresses Prostate Tumor Growth through Inhibition of Epidermal Growth Factor and Androgen Receptor Pathways

Neoplasia: An International Journal for Oncology Research, 2009
Epidermal growth factor receptor (EGFR) and androgen receptor (AR) pathways play pivotal roles in prostate cancer progression. Therefore, agents with dual-targeting ability may have important therapeutic potential.
Yunping Hu, Haiguo Sun, Rick T. Owens, Jiansheng Wu, Yong Q. Chen, Isabelle M. Berquin, Donna Perry, Joseph T. O'Flaherty, Iris J. Edwards   +8 more
doaj   +1 more source

Tumor-specific inhibitory action of decorin on different hepatoma cell lines.

Cellular Signalling, 2019
BACKGROUND In spite of therapeutic approaches, liver cancer is still one of the deadliest type of tumor in which tumor microenvironment may play an active role in the outcome of the disease.
Z. Horváth, Andrea Reszegi, L. Szilák, T. Dankó, I. Kovalszky, Kornélia Baghy   +5 more
semanticscholar   +1 more source

Decorin expression is decreased in human idiopathic fetal growth restriction [PDF]

, 2010
Fetal growth restriction (FGR) is a clinically significant pregnancy disorder in which the fetus fails to achieve its full growth potential in utero. Most cases of FGR are idiopathic and are associated with placental thrombosis.
P. T. Monagle, V. Ignjatovic, P. Murthi, B. C. Swan, J. M. Said, G. Rajaraman, S. P. Brennecke, N. A. Pathirage   +7 more
core   +1 more source

Generation of a multi‐functional, target organ‐specific, anti‐fibrotic molecule by molecular engineering of the extracellular matrix protein, decorin

British Journal of Pharmacology, 2018
Extracellular matrix (ECM) molecules play important roles in regulating processes such as cell proliferation, migration, differentiation and survival. Decorin is a proteoglycan that binds to (‘decorates’) collagen fibrils in the ECM.
T. Järvinen, E. Ruoslahti
semanticscholar   +1 more source