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Differential Interactions of Decorin and Decorin Mutants With Type I and Type VI Collagens
FEBS Journal, 2004The small leucine‐rich proteoglycan decorin can bind via its core protein to different types of collagens such as type I and type VI. To test whether decorin can act as a bridging molecule between these collagens, the binding properties of wild‐type decorin, two full‐length decorin species with single amino acid substitutions (DCN E180K, DCN E180Q ...
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Matrix Biology, 2000Decorin and glypican are two examples of exclusively chondroitin/dermatan sulfate and heparan sulfate-substituted proteoglycans, respectively. Decorin is a secretory product, whereas glypican is linked to membrane lipids via a glycosyl-phosphatidyl-inositol (GPI) anchor.
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Decorin in the Tumor Microenvironment
2020The tumor microenvironment plays a determining role in cancer development through a plethora of interactions between the extracellular matrix and tumor cells. Decorin is a prototype member of the SLRP family found in a variety of tissues and is expressed in the stroma of various forms of cancer. Decorin has gained recognition for its essential roles in
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