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Differential interactions of decorin and decorin mutants with type I and type VI collagens

FEBS Journal, 2004
The small leucine‐rich proteoglycan decorin can bind via its core protein to different types of collagens such as type I and type VI. To test whether decorin can act as a bridging molecule between these collagens, the binding properties of wild‐type decorin, two full‐length decorin species with single amino acid substitutions (DCN E180K, DCN E180Q ...
Daniela G Seidler   +2 more
exaly   +3 more sources

Biosynthesis of decorin and glypican

Matrix Biology, 2000
Decorin and glypican are two examples of exclusively chondroitin/dermatan sulfate and heparan sulfate-substituted proteoglycans, respectively. Decorin is a secretory product, whereas glypican is linked to membrane lipids via a glycosyl-phosphatidyl-inositol (GPI) anchor.
L A, Fransson   +5 more
openaire   +2 more sources

Decorin in the Tumor Microenvironment

2020
The tumor microenvironment plays a determining role in cancer development through a plethora of interactions between the extracellular matrix and tumor cells. Decorin is a prototype member of the SLRP family found in a variety of tissues and is expressed in the stroma of various forms of cancer. Decorin has gained recognition for its essential roles in
Kornélia, Baghy   +3 more
openaire   +2 more sources

Effect of Exogenous Decorin on Cell Morphology and Attachment of Decorin-Deficient Fibroblasts

Journal of Biochemistry, 1996
We have reported deficient expression of decorin on skin fibroblasts from a patient with carbohydrate-deficient glycoprotein syndrome type I [Gu, J. and Wada, Y. (1995) J. Biochem. 117, 1276-1279]. The characteristics of fibroblasts from this patient included increased cell spreading and reduced proliferation.
J, Gu, Y, Wada
openaire   +2 more sources

Reconstruction of glycosaminoglycan chains in decorin

Biochemical and Biophysical Research Communications, 2002
The glycosaminoglycan chain of decorin from human spinal ligaments was digested using the hydrolysis of bovine testicular hyaluronidase. As a result, decorin with hexasaccharide, octasaccharide, and decasaccharide including the linkage region, GlcA-Gal-Gal-Xyl, was obtained.
Mito, Iwafune   +6 more
openaire   +2 more sources

Glomerular expression of biglycan and decorin and urinary levels of decorin in primary glomerular disease

Clinical Nephrology, 2004
Recent studies have suggested that small leucine-rich proteoglycans (SLRP) of the extracellular matrix play a major role in modulating the activity of growth factors and in regulating the deposition of collagens. In this study, the expression of the SLRPs biglycan and decorin in the glomeruli of patients with primary glomerular disease (minimal change ...
M, Kuroda   +6 more
openaire   +2 more sources

Downregulation of Decorin and Transforming Growth Factor-β1 by Decorin Gene Suppression in Tendinocytes

Connective Tissue Research, 2005
Scars formed after tendonitis result in altered tissue mechanical properties after injury. The interaction of collagen molecules with decorin affects collagen fibrogenesis, and scar tissue is fragile as a consequence of a large amount of decorin in the scar.
Yoshinao, Hosaka   +3 more
openaire   +2 more sources

Structures of decorine and delcoridine

Chemistry of Natural Compounds, 1981
In order to confirm the structures of the alkaloids delcorine and delcoridine (O-demethyldelcorine) suggested previously, a direct passage has been performed from delcoridine to delcorine and from delcorine to delphatine. It has been shown that the α configuration of C1 - OCH3 previously suggested for delcorine and delcoridine is incorrect — it should ...
B. T. Salimov   +2 more
openaire   +1 more source

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