Results 71 to 80 of about 18,940 (249)

Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type

Chinese Journal of Lung Cancer, 2011
Background and objective Decorin is a protein component of the extracellular matrix. It has been proven that decorin plaid an important role in matrix assembly. The protein is also capable of suppressing tumor cell growth.
Yongkai WU, Ting XIAO, Min LI, Ying ZHANG, Yanning GAO, Kelin SUN   +5 more
doaj   +1 more source

Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression

Proceedings of the National Academy of Sciences of the United States of America
Significance Decorin is a stromal proteoglycan with oncosuppressive functions, primarily by regulating several tyrosine kinase receptors involved in cancer growth and angiogenesis.
D. Mondal, C. Xie, Gabriel J. Pascal, Simone Buraschi, Renato V. Iozzo   +4 more
semanticscholar   +1 more source

Biosynthesis of the Proteoglycan Decorin [PDF]

European Journal of Biochemistry, 1997
Biosynthesis of decorin was investigated by incubating a rat fibroblast cell line with various radio‐labelled protein and galactosaminoglycan precursors. The following cell‐associated and distinct intermediates were isolated and identified: a pool of non‐glycosylated core protein, two pools of decorin with incomplete chains, one with three sulphated ...
J, Moses, A, Oldberg, E, Eklund, L A, Fransson   +3 more
openaire   +2 more sources

Analysis of decorin expression using GeneSapiens database. [PDF]

, 2013
Box plot analysis of relative decorin gene expression in tissue samples of normal and malignant human urinary bladder using GeneSapiens in silico database (http://www.genesapiens.org/).
Peter J. Boström (470005), Matti Laato (145893), Annele Sainio (470001), Pia Boström (470004), Marie Nyman (470002), Riikka Lund (465685), Hannu Järveläinen (470006), Sanna Vuorikoski (470003)   +7 more
core   +1 more source

MT1-MMP-Mediated cleavage of decorin in corneal angiogenesis [PDF]

, 2009
Background/Aims: Decorin has been shown to have antiangiogenic properties. In this study, we evaluate the involvement of membrane type 1-matrix metalloproteinase (MT1-MMP), a proangiogenic enzyme, in decorin cleavage in the cornea.
Chang, JH, Onguchi, T, Kojima, T, Zhou, Z, Azar, DT, Kim, TI, Han, KY, Mimura, T   +7 more
core   +4 more sources

Elucidating Decorin’s role in the preovulatory follicle [PDF]

Journal of Ovarian Research, 2020
Abstract Background DCN (decorin) is a proteoglycan known to be involved in regulating cell proliferation, collagen fibril organization and migration. In our global transcriptome RNA-sequencing approach to systematically identify new ovulation-associated genes, DCN was identified as one of the highly regulated genes.
A. Kedem, K. Ulanenko-Shenkar, Y. Yung, G. M. Yerushalmi, E. Maman, A. Hourvitz   +5 more
openaire   +3 more sources

The effect of topical decorin on temporal changes to corneal immune cells after epithelial abrasion

Journal of Neuroinflammation, 2022
Background Corneal immune cells interact with corneal sensory nerves during both homeostasis and inflammation. This study sought to evaluate temporal changes to corneal immune cell density in a mouse model of epithelial abrasion and nerve injury, and to ...
Mengliang Wu, Laura E. Downie, Lisa J. Hill, Holly R. Chinnery   +3 more
doaj   +1 more source

Myopathy Associated With Dermatan Sulfate-Deficient Decorin and Myostatin in Musculocontractural Ehlers-Danlos Syndrome: A Mouse Model Investigation

Frontiers in Cell and Developmental Biology, 2021
Carbohydrate sulfotransferase 14 (CHST14) encodes dermatan 4-O-sulfotransferase 1, a critical enzyme for dermatan sulfate (DS) biosynthesis. Musculocontractural Ehlers-Danlos syndrome (mcEDS) is associated with biallelic pathogenic variants of CHST14 and
Yuko Nitahara-Kasahara, Yuko Nitahara-Kasahara, Guillermo Posadas-Herrera, Shuji Mizumoto, Aki Nakamura-Takahashi, Yukiko U. Inoue, Takayoshi Inoue, Yoshihiro Nomura, Shin’ichi Takeda, Shuhei Yamada, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Takashi Okada   +14 more
doaj   +1 more source

Decorin is a novel antagonistic ligand of the Met receptor. [PDF]

, 2009
Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell growth by down-regulating the epidermal growth factor receptor.
Owens, Rick T, McQuillan, David J, Renato V. Iozzo, Alexander Nyström, Keith Ireton, Goldoni, Silvia, Sampurna Sattar, McQuillan, David J., Rick T. Owens, Owens, Rick T., Humphries, Ashley, Iozzo, Renato V, Ashley Humphries, David J. McQuillan, Sattar, Sampurna, Nyström, Alexander, Iozzo, Renato V., Silvia Goldoni, Ireton, Keith   +18 more
core   +2 more sources

Decorin impeded the advancement of thyroid papillary carcinoma by thwarting the EGFR/ FER/ SHP2 signaling-induced sustenance of early endosomes

Heliyon
Objective: This study explores the inhibition of papillary thyroid carcinoma proliferation by Decorin via the EGFR/SHP2/FER pathway. Method: ology: Thirty-two pairs of papillary thyroid carcinoma tissues and adjacent normal tissues were collected for ...
Yaping Liu, Yunchao Xin, Tianyun Lv, Zhicheng Chang, Gang Xue, Xiaoling Shang   +5 more
doaj   +1 more source