Results 71 to 80 of about 15,701 (207)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions

, 2016
International audienceDecorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and autophagy. This functional versatility arises from a
Gubbiotti, Maria A., Renato V. Iozzo, Maria A. Gubbiotti, Iozzo, Renato V., Sylvie Ricard-Blum, Vallet, Sylvain D., Ricard-Blum, Sylvie, Sylvain D. Vallet   +7 more
core   +1 more source

Sequencing the Dermatan Sulfate Chain of Decorin [PDF]

Journal of the American Chemical Society, 2017
Glycomics represents one of the last frontiers and most challenging in omic analysis. Glycosylation occurs in the endoplasmic reticulum and the Golgi organelle and its control is neither well-understood nor predictable based on proteomic or genomic analysis.
Yanlei Yu, Jiana Duan, Franklin E. Leach, Toshihiko Toida, Kyohei Higashi, Hong Zhang, Fuming Zhang, I. Jonathan Amster, Robert J. Linhardt   +8 more
openaire   +2 more sources

Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice

Journal of Sport and Health Science
Purpose: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood. The purpose of this study was to examine the mechanisms behind the protective effects of exercise.
Marit Hjorth, Casey L. Egan, Guilherme D. Telles, Martin Pal, David Gallego-Ortega, Oliver K. Fuller, Emma D. McLennan, Ryan D. Gillis, Tae Gyu Oh, George E.O. Muscat, Surafel Tegegne, Michael S.M. Mah, Joanna Skhinas, Emma Estevez, Timothy E. Adams, Matthew J. McKay, Mark Molloy, Kevin I. Watt, Hongwei Qian, Paul Gregorevic, Thomas R. Cox, Pernille Hojman, Julie Midtgaard, Jesper F. Christensen, Martin Friedrichsen, Renato V. Iozzo, Erica K. Sloan, Brian G. Drew, Jørgen F.P. Wojtaszewski, Martin Whitham, Mark A. Febbraio   +30 more
doaj   +1 more source

Injectable Decorin/Gellan Gum Hydrogel Encapsulating Adipose-Derived Stem Cells Enhances Anti-Inflammatory Effect in Cartilage Injury via Autophagy Signaling

Cell Transplantation, 2023
Adipose-derived stem cells (ADSCs) are employed as a promising alternative in treating cartilage injury. Regulating the inflammatory “fingerprint” of ADSCs to improve their anti-inflammatory properties could enhance therapy efficiency.
Weiping He, Yu Wu, Zhihong Luo, Genghua Yang, Woquan Ye, Xi Chen, Jianhua Ren, Tangzhao Liang, Zhiqiang Liao, Shihai Jiang, Kun Wang   +10 more
doaj   +1 more source

Quantitative collagen and proteoglycan imaging reveal organic layering, gradients and regional texture in young mature dental cementum

VIEW, EarlyView.
Cementum, the mineralized tissue covering all mammalian tooth roots, helps maintain tooth stability, but its internal organization is still poorly understood. In this study, we combine quantitative histologial methods to map the regional distributions of collagen fibers and proteoglycan‐rich matrix layers in porcine cementum.
Jie Zhen, Yuyang Mao, Hamza Elfarraj, Paul Zaslansky   +3 more
wiley   +1 more source

Epigenetic signatures of attention problems in youth with childhood exposure to family and community violence

Psychiatry and Clinical Neurosciences, EarlyView.
Aim The link between violence‐related epigenetic changes and attentional problems (APs) is still not well understood. This article examines if exposure to family and community violence during childhood and adolescence may shape DNA methylation patterns associated with attention in youth.
Renata Queiroz Ramos, Adriane Feijó Evangelista, Cosme Marcelo Furtado Passos da Silva, Fernanda Serpeloni, Joviana Quintes Avanci, Natasha Reis Lacerda, Simone Gonçalves de Assis   +6 more
wiley   +1 more source

Estrogen Receptor Expression Changes After Puberty in the Porcine Anterior Cruciate Ligament

Journal of Orthopaedic Research, Volume 44, Issue 11, November 2026.
Schematic highlighting the study design and approach to characterize genetic differences and hormone receptor expression differences between the AM and PL bundles across growth. Pre‐ and post‐pubescent female pigs had their ACLs removed, separated by bundle, and then characterized using gene expression, western blot, and immunofluorescence.
Jacob D. Thompson, Margaret E. Easson, Matthew B. Fisher   +2 more
wiley   +1 more source

Decreased decorin expression in the tumor microenvironment [PDF]

Cancer Medicine, 2014
AbstractDecorin is a small leucine‐rich proteoglycan, synthesized and deposited by fibroblasts in the stroma where it binds to collagen I. It sequesters several growth factors and antagonizes numerous members of the receptor tyrosine kinase family. In experimental murine systems, it acted as a potent tumor suppressor.
Bozoky B, Savchenko A, Guven H, Ponten F, Klein G, Szekely L   +5 more
openaire   +3 more sources

Alterations in the Immune‐Fibrotic Axis Are Spatially Localized in the Aging Heart

Aging Cell, Volume 25, Issue 11, November 2026.
Aging does not affect the heart uniformly: unique changes in immune cells (macrophages) and scar‐forming cells (fibroblasts) first appear in the valves and aorta and spread into the heart muscle with age. Aged fibroblasts also develop features shared with human heart fibroblasts that may contribute to declining cardiovascular health.
Aleksandra Aljakna Khan, Amalia Sintou, Yue Zhao, Antonios Somarakis, Harshpreet Chandok, Juliana Alcoforado Diniz, Ramalakshmi Ramasamy, Gretchen T. Clark, Leon Frommer, Sikander Hayat, Brian S. White, Paul Robson, Ron Korstanje, J. Matthew Mahoney, Nadia A. Rosenthal   +14 more
wiley   +1 more source