Results 51 to 60 of about 23,792 (227)

Selective inactivity of TGF‐β/decorin complexes [PDF]

FEBS Letters, 1994
Previous studies had shown that binding of TGF‐β to the small proteoglycan decorin results in its inactivation. Indeed, in osteosarcoma cells the addition of decorin prevented the TGF‐β1‐mediated up‐regulation of biglycan synthesis. However, the down‐regulation of proteoglycan‐100 remained unaltered.
Hausser, Heinz, Gröning, Arndt, Hasilik, Andrej, Schönherr, Elke, Kresse, Hans   +4 more
openaire   +2 more sources

Decorin transfection induces proteomic and phenotypic modulation in breast cancer cells 8701-BC [PDF]

, 2008
Decorin is a prototype member of the small leucine-rich proteoglycan family widely distributed in the extracellular matrices of many connective tissues, where it has been shown to play multiple important roles in the matrix assembly process, as well as ...
Cancemi P, Di Cara G, Feo S, Forlino A, Martini D, Minafra L, Minafra S., Pucci-minafra Ida, Ruggeri A, Tenni R, Tira Me   +10 more
core   +1 more source

Decorin impeded the advancement of thyroid papillary carcinoma by thwarting the EGFR/ FER/ SHP2 signaling-induced sustenance of early endosomes

Heliyon
Objective: This study explores the inhibition of papillary thyroid carcinoma proliferation by Decorin via the EGFR/SHP2/FER pathway. Method: ology: Thirty-two pairs of papillary thyroid carcinoma tissues and adjacent normal tissues were collected for ...
Yaping Liu, Yunchao Xin, Tianyun Lv, Zhicheng Chang, Gang Xue, Xiaoling Shang   +5 more
doaj   +1 more source

Myopathy Associated With Dermatan Sulfate-Deficient Decorin and Myostatin in Musculocontractural Ehlers-Danlos Syndrome: A Mouse Model Investigation

Frontiers in Cell and Developmental Biology, 2021
Carbohydrate sulfotransferase 14 (CHST14) encodes dermatan 4-O-sulfotransferase 1, a critical enzyme for dermatan sulfate (DS) biosynthesis. Musculocontractural Ehlers-Danlos syndrome (mcEDS) is associated with biallelic pathogenic variants of CHST14 and
Yuko Nitahara-Kasahara, Yuko Nitahara-Kasahara, Guillermo Posadas-Herrera, Shuji Mizumoto, Aki Nakamura-Takahashi, Yukiko U. Inoue, Takayoshi Inoue, Yoshihiro Nomura, Shin’ichi Takeda, Shuhei Yamada, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Takashi Okada   +14 more
doaj   +1 more source

Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells [PDF]

Journal of Histochemistry & Cytochemistry, 2019
The extracellular matrix proteoglycan decorin is well-known for its oncosuppressive activity. Here, decorin expression was examined in human vulva carcinoma tissue samples and in primary and commercial cell lines representing this malignant disease.
Nyman, MC, Jokilammi, AB, Boström PC, Kurki, SH, Sainio, AO, Grenman, SE, Orte, KJ, Hietanen, SH, Elenius, K, Järveläinen HT   +9 more
openaire   +3 more sources

The effect of topical decorin on temporal changes to corneal immune cells after epithelial abrasion

Journal of Neuroinflammation, 2022
Background Corneal immune cells interact with corneal sensory nerves during both homeostasis and inflammation. This study sought to evaluate temporal changes to corneal immune cell density in a mouse model of epithelial abrasion and nerve injury, and to ...
Mengliang Wu, Laura E. Downie, Lisa J. Hill, Holly R. Chinnery   +3 more
doaj   +1 more source

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K., Hageman, J., Herrema, H.J., Kuipers, F.   +3 more
core   +3 more sources

Decorin knockdown affects the gene expression profile of adhesion, growth and extracellular matrix metabolism in C-28/I2 chondrocytes.

PLoS ONE, 2020
Decorin is a member of small leucine-rich proteoglycan family, which is involved in multiple biological functions mainly as a structural and signaling molecule, and disturbances in its own metabolism plays a crucial role in the pathogenesis of ...
Mengying Wang, Zhengzheng Li, Meng Zhang, Hui Wang, Ying Zhang, Yiping Feng, Yinan Liu, Jinghong Chen   +7 more
doaj   +1 more source

Supramolecular Engineering of Fluid Pressure in Filamentous Hybrid Double Network Hydrogels for 3D Chondrocyte Culture

Advanced Healthcare Materials, EarlyView.
Inspired by the water‐rich and interconnected biopolymer networks of native load‐bearing tissues, we disclose a connectable design for a hybrid filamentous supramolecular and covalent double network hydrogel generated through in situ photopolymerization.
Ciqing Tong, Ying Chen, Merel L. Janssen, Isabel Sariol, Joeri A. J. Wondergem, Marijn van den Brink, Mertcan Özel, Rob G. H. H. Nelissen, Ingrid Meulenbelt, Doris Heinrich, Yolande F. M. Ramos, Roxanne E. Kieltyka   +11 more
wiley   +1 more source

Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy

Life, 2021
Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization ...
Shermaine W. Y. Low, Tanuja Vaidya, Santosh G. K. Gadde, Thirumalesh B. Mochi, Devesh Kumar, Iris S. Kassem, Deborah M. Costakos, Baseer Ahmad, Swaminathan Sethu, Arkasubhra Ghosh, Shyam S. Chaurasia   +10 more
doaj   +1 more source