Results 21 to 30 of about 15,701 (207)
Decorin Is a Zn2+ Metalloprotein [PDF]
Journal of Biological Chemistry, 1999 Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by leucine-rich repeat motifs. We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high ...
V W, Yang +4 more
openaire +2 more sources
MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. [PDF]
PLoS ONE, 2015 Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated
Peter Kwan, Jie Ding, Edward E Tredget
doaj +1 more source
Decorin Inhibits Dermal Mesenchymal Cell Migration and Induces Scar Formation
Plastic and Reconstructive Surgery, Global Open, 2022 Background:. Variations in skin healing capacities are observed during different murine embryonic developmental stages. Through embryonic day 16 (E16), embryos are able to regenerate dermal architecture following flank skin wounding; however, after E17 ...
Kento Takaya, MD +5 more
doaj +1 more source
A central role for decorin during vertebrate convergent extension
, 2009 Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, regulates collagen fibrillogenesis and cell growth. To further explore its biological function, we examined the role of Decorin during zebrafish development.
Zoeller, Jason J. +8 more
core +8 more sources
Pivotal role for decorin in angiogenesis [PDF]
Matrix Biology, 2015 Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly complex process. It is regulated in a finely-tuned manner by numerous molecules including not only soluble growth factors such as vascular endothelial growth factor and several other growth factors, but also a diverse set of insoluble molecules, particularly ...
Järveläinen, Hannu +2 more
openaire +3 more sources
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-Cadherin in vitro and in mice [PDF]
, 2012 Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a ...
Renato V. Iozzo (7451198) +8 more
core +3 more sources
npj Regenerative Medicine, 2023 Heart failure (HF) remains a global public health burden and often results following myocardial infarction (MI). Following injury, cardiac fibrosis forms in the myocardium which greatly hinders cellular function, survival, and recruitment, thus severely ...
Priya Mohindra +11 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the functional role of B.
Yifeng Lin +7 more
doaj +1 more source
Frontiers in Oncology, 2021 Decorin exhibits inhibitory effects in tumorigenesis in various types of cancers. The clinical characteristics of 42 patients with GBM were reviewed and analyzed.
Yanfei Jia +6 more
doaj +1 more source
The American Journal of Pathology, 2012 Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the transforming growth factor-β ligand superfamily.
Neill, Thomas +2 more
openaire +3 more sources