Results 21 to 30 of about 15,201 (170)
Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]
, 2005 Background: Sub- epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Reinhardt Alistair K +11 more
core +2 more sources
Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase. [PDF]
PLoS ONE, 2013 Exposure of human skin to solar ultraviolet (UV) irradiation induces matrix metalloproteinase-1 (MMP-1) activity, which degrades type I collagen fibrils. Type I collagen is the most abundant protein in skin and constitutes the majority of skin connective
Yong Li +5 more
doaj +1 more source
Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis
Acta Neuropathologica Communications, 2022 Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App NL-F/NL-F and App NL-G-F/NL-G-F , exhibiting AD-like
Richeng Jiang +24 more
doaj +1 more source
Dichotomy of decorin activity on the insulin-like growth factor-I system [PDF]
, 2013 The stromal-specific proteoglycan decorin has emerged in recent years as a critical regulator of tumor initiation and progression. Decorin regulates the biology of various types of cancer by modulating the activity of several receptor tyrosine kinases ...
Neill, Thomas +3 more
core +1 more source
, 2011 Atherosclerotic cardiovascular disease is a major cause of morbidity and mortality in the Western world. Despite tremendous strides in understandings its pathogenesis, it still remains a challenge because of gaps in our understanding of its initiation ...
Sandeep Singla +3 more
core +3 more sources
Protective Role of Decorin in Primary Hepatocellular Carcinoma
Frontiers in Oncology, 2020 Hepatocellular carcinoma (HCC) represents one of the most frequent type of primary liver cancers. Decorin, a small leucine-rich proteoglycan of the extracellular matrix, represents a powerful tumor cell growth and migration inhibitor by hindering ...
Andrea Reszegi +6 more
doaj +1 more source
Veterinary Sciences, 2023 The aim of this study was to investigate whether using immunohistochemistry to detect the angiogenic proteins vascular endothelial growth factor (VEGF) and decorin can help predict the risk of local recurrence of, or death from, canine soft tissue ...
Jonathan P. Bray +2 more
doaj +1 more source
Role of Decorin in the Lens and Ocular Diseases
Cells, 2022 Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine
Eri Kubo +4 more
doaj +1 more source
Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo. [PDF]
PLoS ONE, 2011 Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissues. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the rabbit stroma with adeno-associated virus serotype
Rajiv R Mohan +5 more
doaj +1 more source
Decorin deficiency promotes hepatic carcinogenesis [PDF]
, 2015 Hepatocellular carcinoma represents one of the most-rapidly spreading cancers in the world. In the majority of cases, an inflammation-driven fibrosis or cirrhosis precedes the development of the tumor.
Fullár, Alexandra +6 more
core +1 more source