Results 21 to 30 of about 18,940 (249)

Human Metaplastic Breast Carcinoma and Decorin [PDF]

Cancer Microenvironment, 2017
Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracellular matrix (ECM). However, little is known about the composition of the ECM and its constituents in MBC.
Pia Boström, Annele Sainio, Natalja Eigėlienė, Anne Jokilammi, Klaus Elenius, Ilkka Koskivuo, Hannu Järveläinen   +6 more
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An Antimetastatic Role for Decorin in Breast Cancer [PDF]

The American Journal of Pathology, 2008
Decorin, a member of the small leucine-rich proteoglycan gene family, down-regulates members of the ErbB receptor tyrosine kinase family and attenuates their signaling, leading to growth inhibition. We investigated the effects of decorin on the growth of ErbB2-overexpressing mammary carcinoma cells in comparison with AG879, an established ErbB2 kinase ...
Goldoni S, Seidler DG, Heath J, FASSAN, MATTEO, BAFFA, RAFFAELE, Thakur ML, Owens RT, McQuillan DJ, Iozzo RV   +8 more
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The neuroregenerative effects of topical decorin on the injured mouse cornea

Journal of Neuroinflammation, 2020
Background The cornea is innervated with a rich supply of sensory nerves that play important roles in ocular surface health. Any injury or pathology of the corneal nerves increases the risk of dry eye disease and infection.
Mengliang Wu, Laura E. Downie, Liam M. Grover, Richard J. A. Moakes, Saaeha Rauz, Ann Logan, Haihan Jiao, Lisa J. Hill, Holly R. Chinnery   +8 more
doaj   +2 more sources

Isolation and characterization of rat skeletal muscle proteoglycan decorin and comparison with the human fibroblast decorin [PDF]

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1991
1. The extracellular matrix (ECM) of rat skeletal muscle contains several proteoglycans (PGs). The more abundant correspond to a chondroitin/dermatan sulfate PG or decorin. 2. Decorin isolated from rat skeletal muscle ECM has a smaller molecular size than human fibroblast decorin. 3.
Andrade, W., Brandan, Enrique
openaire   +4 more sources

Decorin levels and cardiometabolic function after endurance exercise [PDF]

Frontiers in Physiology
IntroductionDecorin is secreted from myotubes in response to exercise and plays a vital role in repairing and regenerate skeletal and cardiac muscle.
Antônio Alves de Fontes-Junior, Cesar Augustus Zocoler de Sousa, Leandro Barbosa de Oliveira, Ana Paula Renno Sierra, Maria Fernanda Cury-Boaventura   +4 more
doaj   +2 more sources

Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions [PDF]

Matrix Biology, 2016
Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and autophagy. This functional versatility arises from a wide array of decorin/
Maria A. Gubbiotti, Sylvain D. Vallet, S. Ricard-Blum, R. Iozzo   +3 more
semanticscholar   +2 more sources

Decorin Deficiency Promotes D‐Galactose–Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Primary sarcopenia is an age‐associated disorder with progressive and generalised loss of skeletal muscle strength and mass. Skeletal muscle fibrosis is one of the significant pathological manifestations of age‐associated sarcopenia.
Xiaoqin Luo, Mengxue Zhang, Lili Chen, Ruichang Wang, Jiabing Lian, Zhe Yang, Renato V. Iozzo, Jin Wang, Yan Zhang, Xiuli Bi   +9 more
doaj   +2 more sources

Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury

Molecules, 2020
Search for new cardioprotective therapies is of great importance since no cardioprotective drugs are available on the market. In line with this need, several natural biomolecules have been extensively tested for their potential cardioprotective effects ...
Renáta Gáspár, Kamilla Gömöri, Bernadett Kiss, Ágnes Szántai, János Pálóczi, Zoltán V. Varga, Judit Pipis, Barnabás Váradi, Bence Ágg, Tamás Csont, Péter Ferdinandy, Monika Barteková, Anikó Görbe   +12 more
doaj   +2 more sources

Decreased decorin expression in the tumor microenvironment [PDF]

Cancer Medicine, 2014
AbstractDecorin is a small leucine‐rich proteoglycan, synthesized and deposited by fibroblasts in the stroma where it binds to collagen I. It sequesters several growth factors and antagonizes numerous members of the receptor tyrosine kinase family. In experimental murine systems, it acted as a potent tumor suppressor.
Bozoky B, Savchenko A, Guven H, Ponten F, Klein G, Szekely L   +5 more
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The Role of Decorin Proteoglycan in Mitophagy [PDF]

Cancers, 2022
Proteoglycans are emerging as critical regulators of intracellular catabolism. This rise in prominence has transformed our basic understanding and alerted us to the existence of non-canonical pathways, independent of nutrient deprivation, that potently control the autophagy downstream of a cell surface receptor.
Thomas Neill, Renato V. Iozzo
openaire   +2 more sources