Results 11 to 20 of about 23,792 (227)
Focus on Molecules: Decorin [PDF]
Experimental Eye Research, 2011 Decorin (NM_133507) is a ubiquitous small extracellular proteoglycan. It is a composite molecule ~100kda in size with a protein core and attached GAGs. It was cloned from a human embryonic fibroblast line and named PG40 for its protein core, ~40Kda.
Shoujun, Chen, David E, Birk
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Oncosuppressive functions of decorin [PDF]
Molecular & Cellular Oncology, 2015 The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble tumor repressor.
Neill, Thomas +2 more
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The American Journal of Pathology, 2012 Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the transforming growth factor-β ligand superfamily.
Neill, Thomas +2 more
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Journal of the Formosan Medical Association, 2022 Background/purpose: Decorin is a small leucine-rich proteoglycan rich in extracellular matrix with potential antitumor activity. However, the role of decorin in hematological malignancies remains unclear, especially in the case of multiple myeloma (MM ...
Shang-Yi Huang +8 more
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The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma
Biomolecules, 2020 Decorin, the prototype member of the small leucine-rich proteoglycan gene family of extracellular matrix (ECM) proteins, acts as a powerful tumor suppressor by inducing the p21Waf1/Cip1 cyclin-dependent kinase inhibitor, as well as through its ability to
Andrea Reszegi +9 more
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Decorin Is a Zn2+ Metalloprotein [PDF]
Journal of Biological Chemistry, 1999 Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by leucine-rich repeat motifs. We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high ...
V W, Yang +4 more
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Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis
EBioMedicine, 2020 Background: Progressive peritoneal fibrosis is a common complication in patients on long-term peritoneal dialysis (PD). PD-associated peritonitis is a major exacerbating factor.
Na Jiang +9 more
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MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. [PDF]
PLoS ONE, 2015 Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated
Peter Kwan, Jie Ding, Edward E Tredget
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Decorin Inhibits Dermal Mesenchymal Cell Migration and Induces Scar Formation
Plastic and Reconstructive Surgery, Global Open, 2022 Background:. Variations in skin healing capacities are observed during different murine embryonic developmental stages. Through embryonic day 16 (E16), embryos are able to regenerate dermal architecture following flank skin wounding; however, after E17 ...
Kento Takaya, MD +5 more
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Human Metaplastic Breast Carcinoma and Decorin [PDF]
Cancer Microenvironment, 2017 Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracellular matrix (ECM). However, little is known about the composition of the ECM and its constituents in MBC.
Pia Boström +6 more
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