Results 11 to 20 of about 14,247 (218)
Therapeutic Advances in Cardiovascular Disease, 2011 Atherosclerotic cardiovascular disease is a major cause of morbidity and mortality in the Western world. Despite tremendous strides in understandings its pathogenesis, it still remains a challenge because of gaps in our understanding of its initiation ...
Sandeep Singla +3 more
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Oncosuppressive functions of decorin [PDF]
Molecular & Cellular Oncology, 2015 The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble
Neill, Thomas +2 more
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Human Metaplastic Breast Carcinoma and Decorin [PDF]
Cancer Microenvironment, 2022 Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracellular matrix (ECM).
Sainio A +6 more
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Decorin A Guardian from the Matrix
The American Journal of Pathology, 2012 Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the transforming ...
Neill, Thomas +3 more
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Role of Decorin in the Lens and Ocular Diseases
Cells, 2022 Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine
Eri Kubo +4 more
doaj +3 more sources
Increased expression of decorin in experimental hydronephrosis
Kidney International, 1997 Increased expression of decorin in experimental hydronephrosis. Transforming growth factor (TGF)-βl is a potential mediator of tubulo-interstitial (TI) fibrosis in the rat unilateral ureteral obstruction (UUO) model.
Levinson, Mark +3 more
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Pivotal role for decorin in angiogenesis [PDF]
Matrix Biology, 2015 Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly complex process. It is regulated in a finely-tuned manner by numerous molecules including not only soluble growth factors such as vascular endothelial growth factor ...
Järveläinen, Hannu +2 more
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An antimetastatic role for decorin in breast cancer [PDF]
The American Journal of Pathology, 2008 Decorin, a member of the small leucine-rich proteoglycan gene family, down-regulates members of the ErbB receptor tyrosine kinase family and attenuates their signaling, leading to growth inhibition. We investigated the effects of decorin on the growth of
Matteo Fassan +17 more
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Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1991 1. The extracellular matrix (ECM) of rat skeletal muscle contains several proteoglycans (PGs). The more abundant correspond to a chondroitin/dermatan sulfate PG or decorin.2. Decorin isolated from rat skeletal muscle ECM has a smaller molecular size than
BRANDAN, E, ANDRADE, W
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The Role of Decorin Proteoglycan in Mitophagy [PDF]
Cancers, 2022 Proteoglycans are emerging as critical regulators of intracellular catabolism. This rise in prominence has transformed our basic understanding and alerted us to the existence of non-canonical pathways, independent of nutrient deprivation, that potently control the autophagy downstream of a cell surface receptor.
Thomas Neill, Renato V. Iozzo
openaire +2 more sources