Results 11 to 20 of about 15,701 (207)
Oncosuppressive functions of decorin [PDF]
Molecular & Cellular Oncology, 2015 The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble
Neill, Thomas +2 more
core +4 more sources
Human Metaplastic Breast Carcinoma and Decorin [PDF]
Cancer Microenvironment, 2022 Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracellular matrix (ECM).
Sainio A +6 more
core +5 more sources
Therapeutic Advances in Cardiovascular Disease, 2011 Atherosclerotic cardiovascular disease is a major cause of morbidity and mortality in the Western world. Despite tremendous strides in understandings its pathogenesis, it still remains a challenge because of gaps in our understanding of its initiation ...
Mehta, Jawahar L +3 more
core +5 more sources
The Role of Decorin in Autoimmune and Inflammatory Diseases
Journal of Immunology Research, 2022 Decorin is an extracellular matrix protein that belongs to the family of small leucine-rich proteoglycans. As a matrix protein, the first discovered role of decorin is participating in collagen fibril formation. Many other functions of decorin in various
Yuanji Dong, Jixin Zhong, Lingli Dong
doaj +3 more sources
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1991 1. The extracellular matrix (ECM) of rat skeletal muscle contains several proteoglycans (PGs). The more abundant correspond to a chondroitin/dermatan sulfate PG or decorin.2. Decorin isolated from rat skeletal muscle ECM has a smaller molecular size than
BRANDAN, E, ANDRADE, W
core +4 more sources
Role of Decorin in the Lens and Ocular Diseases
Cells, 2022 Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine
Eri Kubo +4 more
doaj +3 more sources
Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury [PDF]
Molecules, 2020 Search for new cardioprotective therapies is of great importance since no cardioprotective drugs are available on the market. In line with this need, several natural biomolecules have been extensively tested for their potential cardioprotective effects ...
Renáta Gáspár +12 more
doaj +2 more sources
The Role of Decorin Proteoglycan in Mitophagy [PDF]
Cancers, 2022 Proteoglycans are emerging as critical regulators of intracellular catabolism. This rise in prominence has transformed our basic understanding and alerted us to the existence of non-canonical pathways, independent of nutrient deprivation, that potently control the autophagy downstream of a cell surface receptor.
Thomas Neill, Renato V. Iozzo
openaire +2 more sources
Systemic clinical-grade recombinant decorin reduces disease burden and fibrosis in advanced recessive dystrophic epidermolysis bullosa. [PDF]
Mol Ther AdvRecessive dystrophic epidermolysis bullosa (RDEB) is a skin and epithelial fragility disease that progresses with severe fibrosis. This fibrosis is debilitating and promotes the development of aggressive squamous cell carcinomas (SCCs).
Gretzmeier C +12 more
europepmc +2 more sources
Focus on Molecules: Decorin [PDF]
Experimental Eye Research, 2011 Decorin (NM_133507) is a ubiquitous small extracellular proteoglycan. It is a composite molecule ~100kda in size with a protein core and attached GAGs. It was cloned from a human embryonic fibroblast line and named PG40 for its protein core, ~40Kda.
Shoujun, Chen, David E, Birk
openaire +2 more sources