Results 11 to 20 of about 15,201 (170)
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-Cadherin in vitro and in mice [PDF]
, 2012 Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a ...
Renato V. Iozzo (7451198) +8 more
core +7 more sources
The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma
Biomolecules, 2020 Decorin, the prototype member of the small leucine-rich proteoglycan gene family of extracellular matrix (ECM) proteins, acts as a powerful tumor suppressor by inducing the p21Waf1/Cip1 cyclin-dependent kinase inhibitor, as well as through its ability to
Andrea Reszegi +9 more
doaj +1 more source
Decorin Inhibits Dermal Mesenchymal Cell Migration and Induces Scar Formation
Plastic and Reconstructive Surgery, Global Open, 2022 Background:. Variations in skin healing capacities are observed during different murine embryonic developmental stages. Through embryonic day 16 (E16), embryos are able to regenerate dermal architecture following flank skin wounding; however, after E17 ...
Kento Takaya, MD +5 more
doaj +1 more source
Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells [PDF]
, 2022 The extracellular matrix proteoglycan decorin is well-known for its oncosuppressive activity. Here, decorin expression was examined in human vulva carcinoma tissue samples and in primary and commercial cell lines representing this malignant disease ...
Sakari H. Hietanen +9 more
core +1 more source
MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. [PDF]
PLoS ONE, 2015 Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated
Peter Kwan, Jie Ding, Edward E Tredget
doaj +1 more source
npj Regenerative Medicine, 2023 Heart failure (HF) remains a global public health burden and often results following myocardial infarction (MI). Following injury, cardiac fibrosis forms in the myocardium which greatly hinders cellular function, survival, and recruitment, thus severely ...
Priya Mohindra +11 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the functional role of B.
Yifeng Lin +7 more
doaj +1 more source
Frontiers in Oncology, 2021 Decorin exhibits inhibitory effects in tumorigenesis in various types of cancers. The clinical characteristics of 42 patients with GBM were reviewed and analyzed.
Yanfei Jia +6 more
doaj +1 more source
The Scientific World Journal, 2006 The small leucine-rich proteoglycan (SLRP) decorin is efficiently internalized by a variety of cultured cells. A 51-kDa protein has previously been described as a receptor mediating endocytosis of decorin and of the structurally related SLRP biglycan ...
David Denis Sofeu Feugaing +3 more
doaj +1 more source
Indian Journal of Pathology and Microbiology, 2013 Background: Decorin is an extracellular matrix, multifunctional small proteoglycan molecule in tumor stroma that has been shown to be modulator of angiogenesis.
Seema Nayak +8 more
doaj +1 more source