Results 11 to 20 of about 18,940 (249)

Decorin in atherosclerosis [PDF]

Therapeutic Advances in Cardiovascular Disease, 2011
Atherosclerotic cardiovascular disease is a major cause of morbidity and mortality in the Western world. Despite tremendous strides in understandings its pathogenesis, it still remains a challenge because of gaps in our understanding of its initiation, progression and complications leading to the clinical syndromes of angina, acute coronary syndrome ...
Sandeep, Singla, Changping, Hu, Adam, Mizeracki, Jawahar L, Mehta   +3 more
core   +5 more sources

Oncosuppressive functions of decorin [PDF]

Molecular & Cellular Oncology, 2015
The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble tumor repressor.
Neill, Thomas, Schäfer, Liliana, Iozzo, Renato V.   +2 more
openaire   +5 more sources

Possible dual role of decorin in abdominal aortic aneurysm. [PDF]

PLoS ONE, 2015
Abdominal aortic aneurysm (AAA) is characterized by chronic inflammation, which leads to pathological remodeling of the extracellular matrix. Decorin, a small leucine-rich repeat proteoglycan, has been suggested to regulate inflammation and stabilize the
Koshiro Ueda, Koichi Yoshimura, Osamu Yamashita, Takasuke Harada, Noriyasu Morikage, Kimikazu Hamano   +5 more
doaj   +3 more sources

Decorin [PDF]

The American Journal of Pathology, 2012
Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the transforming growth factor-β ligand superfamily.
Neill, Thomas, Schaefer, Liliana, Iozzo, Renato V.   +2 more
core   +5 more sources

The Role of Decorin and Biglycan Signaling in Tumorigenesis [PDF]

Frontiers in Oncology, 2021
The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin ...
Valentina Diehl, L. Huber, J. Trebicka, M. Wygrecka, R. Iozzo, L. Schaefer   +5 more
semanticscholar   +5 more sources

Increased expression of decorin in experimental hydronephrosis [PDF]

Kidney International, 1997
Transforming growth factor (TGF)-beta1 is a potential mediator of tubulointerstitial (TI) fibrosis in the rat unilateral ureteral obstruction (UUO) model. Decorin is a protein composed of a core protein and a chondroitin sulfate side chain and is capable of inactivating TGF-beta.
Diamond, Jonathan R., Levinson, Mark, Kreisberg, Robert, Ricardo, Sharon D.   +3 more
openaire   +3 more sources

Pivotal role for decorin in angiogenesis [PDF]

Matrix Biology, 2015
Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly complex process. It is regulated in a finely-tuned manner by numerous molecules including not only soluble growth factors such as vascular endothelial growth factor and several other growth factors, but also a diverse set of insoluble molecules, particularly ...
Järveläinen, Hannu, Sainio, Annele, Wight, Thomas N.   +2 more
openaire   +5 more sources

Protective Role of Decorin in Primary Hepatocellular Carcinoma

Frontiers in Oncology, 2020
Hepatocellular carcinoma (HCC) represents one of the most frequent type of primary liver cancers. Decorin, a small leucine-rich proteoglycan of the extracellular matrix, represents a powerful tumor cell growth and migration inhibitor by hindering ...
Andrea Reszegi, Zsolt Horváth, Hajnalka Fehér, Barnabás Wichmann, Péter Tátrai, Ilona Kovalszky, Kornélia Baghy   +6 more
doaj   +2 more sources

Salivary decorin as a potential noninvasive biomarker in chronic kidney disease: a comparative study with serum levels [PDF]

Renal Failure
Chronic kidney disease (CKD) is characterized by progressive renal fibrosis and irreversible loss of kidney function. Decorin, an extracellular matrix proteoglycan with antifibrotic properties, may reflect underlying fibrotic activity and has emerged as ...
Asena Serap Karatutlu, Mehmet Ali Karatutlu, Suleyman Aydin   +2 more
doaj   +2 more sources

Impact of Decorin on the Physical Function and Prognosis of Patients with Hepatocellular Carcinoma

Journal of Clinical Medicine, 2020
The outcome of patients with hepatocellular carcinoma (HCC) is still poor. Decorin is a small leucine-rich proteoglycan, which exerts antiproliferative and antiangiogenic properties in vitro.
Dan Nakano, Sachiyo Yoshio, Hiroo Matsuse   +2 more
exaly   +2 more sources