Results 121 to 130 of about 28,403 (287)

Real‐world incidence and risk factors of level 3 (severe) hypoglycaemia in adults with type 1 or 2 diabetes (iNPHORM, United States)

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 675-690, January 2026.
Abstract Aims Level 3 (severe) hypoglycaemia is a serious, yet preventable, complication of insulin‐ or secretagogue‐treated diabetes. However, real‐world insight into its incidence and risk factors remains limited. We analysed data from the iNPHORM study to address this gap.
Alexandria Ratzki‐Leewing, Jason E. Black, Jasminder Bhatti, Bridget L. Ryan, Guangyong Zou, Yu Kuei Lin, Shuo J. Huang, Rozalina G. McCoy, Stewart B. Harris   +8 more
wiley   +1 more source

Evolving trends of antidiabetic agents stratified by age, kidney function and body mass index: Insights from a nationwide claims database

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 701-710, January 2026.
Abstract Aims To analyse prescribing trends in antidiabetic agents stratified by background characteristics among individuals with type 2 diabetes. Materials and Methods This retrospective study used a large‐scale database between 2015 and 2024 in Japan.
Kazuki Aoyama, Akira Okada, Hidehiro Kaneko, Tatsuhiko Azegami, Yuta Suzuki, Shu Meguro, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Toshimasa Yamauchi, Masaomi Nangaku, Norihiko Takeda, Hideo Yasunaga, Kaori Hayashi   +14 more
wiley   +1 more source

Lobeglitazone improves glycaemic control as add‐on therapy to empagliflozin plus metformin in patients with type 2 diabetes mellitus: A double‐blind, randomised, placebo‐controlled trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 728-740, January 2026.
Abstract Aims This study aimed to evaluate the efficacy and safety of triple therapy with lobeglitazone 0.5 mg as an add‐on treatment compared with placebo in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and empagliflozin.
Da Hea Seo, Kyung Wan Min, Ho Sang Sohn, Sang Yong Kim, In‐Kyung Jeong, Cheol‐Young Park, Kun‐Ho Yoon, So Hun Kim, Bong‐Soo Cha   +8 more
wiley   +1 more source

Polyhexamethylene biguanide and its antimicrobial role in wound healing: a narrative review [PDF]

, 2023
Mark G Rippon, Alan A Rogers, Karen Ousey   +2 more
openalex   +1 more source

Assessing the interaction of the UCP system and fatty acids on epicardial adipose tissue mitochondrial respiration

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Epicardial adipose tissue (EAT) demonstrates higher mitochondrial activity than subcutaneous fat (SAT), particularly in NADH‐ and FAO‐linked oxidative phosphorylation (OXPHOS). While EAT expresses more UCP1, its inhibition by GDP minimally affects respiration, especially in FAO pathways, suggesting UCP1‐independence. Diabetes mellitus (DM) and coronary
Diana Santos, Ana Burgeiro, Ana Catarina R. G. Fonseca, Cândida Dias, Teresa Cunha‐Oliveira, Aryane Oliveira, João Laranjinha, António Canotilho, Gonçalo Coutinho, David Prieto, Pedro Antunes, Manuel Antunes, Eugenia Carvalho   +12 more
wiley   +1 more source

Allosteric activation of the 5-HT_3AB receptor by mCPBG [PDF]

, 2015
The 5-HT_3AB receptor contains three A and two B subunits in an A-A-B-A-B order. However, serotonin function at the 5-HT_3AB receptor has been shown to depend solely on the A-A interface present in the homomeric receptor. Using mutations at sites on both
Dougherty, Dennis A., Lester, Henry A., Miles, Timothy F.   +2 more
core  

Risk of Lactic Acidosis in Hospitalized Diabetic Patients Prescribed Biguanides in Japan: A Retrospective Total-Population Cohort Study [PDF]

, 2023
Takako Mohri, Sawako Okamoto, Yuichi Nishioka, Tomoya Myojin, Shinichiro Kubo, Tsuneyuki Higashino, Sadanori Okada, Yasuhiro Akai, Tatsuya Noda, Hitoshi Ishii, Tomoaki Imamura   +10 more
openalex   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

Biguanide chitosan microneedles with cell-free DNA scavenging ability for psoriasis therapy

Bioactive Materials
High levels of cell-free DNA (cfDNA) induce psoriasis. Currently, the treatment of psoriasis has the disadvantages of penetration difficulty, suppression of normal immunity, and skin irritation.
Zihao Liu, Yu Wang, Yuhan Zhang, Liufu Hu, Bozhi Chen, Yang Li, Xindong Guo, Bingran Yu, Fu-Jian Xu   +8 more
doaj   +1 more source

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides [PDF]

, 2017
Laura Hulea, Simon‐Pierre Gravel, Masahiro Morita, Marie Cargnello, Oro Uchenunu, Young Kyuen Im, Shannon McLaughlan, Ola Larsson, Michael Ohh, Tiago Ferreira, Celia M.T. Greenwood, Gaëlle Bridon, Daina Avizonis, Josie Ursini‐Siegel, Julie St‐Pierre, Michaël Pollak, Ivan Topisirović   +16 more
openalex   +1 more source