Results 121 to 130 of about 19,462 (277)

Effects of biguanides on oxidative phosphorylation [PDF]

Cancer & Metabolism, 2014
Metformin, and the related biguanides buformin and phenformin, have been proposed to act by inhibiting respiratory complex I, causing the cellular energetic stress that activates AMP-kinase and initiates a multitude of cell-lineage-specific effects, including inhibition of gluconeogenesis in hepatocytes.
openaire   +2 more sources

Evaluation of a stent dressing and abdominal bandage on surgical site infection following emergency equine laparotomy: A randomised controlled trial

Equine Veterinary Journal, EarlyView.
Abstract Background Surgical site infection (SSI) is a frequent complication following emergency equine laparotomy, negatively impacting equine welfare, increasing treatment costs and presenting a hospital biosecurity risk. Objectives To determine if a sutured‐on stent dressing for incisional protection during anaesthetic recovery reduced SSI following
Cajsa M. Isgren, Gina L. Pinchbeck, Shebl E. Salem, Michelle J. Hann, Neil B. Townsend, Matthew D. Cullen, Debra C. Archer   +6 more
wiley   +1 more source

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis.

PLoS Biology, 2015
Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest as an antineoplastic agent. Recent work suggests that metformin directly antagonizes cancer cell growth through its actions on complex I of the mitochondrial ...
Takla Griss, Emma E Vincent, Robert Egnatchik, Jocelyn Chen, Eric H Ma, Brandon Faubert, Benoit Viollet, Ralph J DeBerardinis, Russell G Jones   +8 more
doaj   +1 more source

COMPLEX COMPOUNDS OF BIGUANIDE WITH BIVALENT METALS. PART II. NICKEL BIGUANIDINES. [PDF]

, 1941
PRIYADARANJAN RAY, BHUPESH CHANDRA PURAKAYASTHA   +1 more
openalex   +1 more source

Differences in cause of death and age at death between people with and without diabetes over 10 years (2010–2020): A cross‐sectional study in Japan

Journal of Diabetes Investigation, EarlyView.
The figure shows the trend in causes of death for individuals with and without diabetes from 2010 to 2020. In both groups, the leading cause of death was malignant neoplasm. ABSTRACT Aims/Introduction Investigating the causes of death in individuals with diabetes compared with those without is essential for understanding diabetes care. However, methods
Hirofumi Sugimoto, Noriko Ihana‐Sugiyama, Takehiro Sugiyama, Noriko Kodani, Ryotaro Bouchi, Mitsuru Ohsugi, Kohjiro Ueki, Hiroshi Kajio   +7 more
wiley   +1 more source

COMPLEX COMPOUNDS OF BIGUANIDE WITH TERVALENT METALS. PART I. CHROMIUM BIGUANIDINES. [PDF]

, 1937
PRIYADARANJAN RAY, HARIBOLA SAHA
openalex   +1 more source

Elevated amputation rates in COVID‐19 survivors: Insights from a large‐scale Japanese cohort study

Journal of Diabetes Investigation, EarlyView.
COVID‐19 is associated with a long‐term increased risk of amputation, persisting for more than 2 years post infection. These findings highlight the need for vigilant vascular monitoring and early intervention to mitigate the long‐term complications of COVID‐19.
Daisuke Miyamori, Shuhei Yoshida, Masanori Ito   +2 more
wiley   +1 more source

BIGUANIDES AND LACTICACIDOSIS [PDF]

The Lancet, 1977
WilliamD. Alexander, J. Marples
openaire   +5 more sources

COMPLEX COMPOUNDS OF BIGUANIDE WITH BIVALENT METALS. PART III. COPPER AND NICKEL PHENYL BIGUANIDINES AND THEIR DIFFERENT MODIFICATIONS. [PDF]

, 1941
PRIYADARAJAN RAY, KSHITISHRANJAN CHAKRAVARTY   +1 more
openalex   +1 more source

Impact of HbA1c variability and time‐in‐range fluctuations on large and small nerve fiber dysfunction in well‐controlled type 2 diabetes: A prospective cohort observational study

Journal of Diabetes Investigation, EarlyView.
Long‐term (HbA1c ARV) and short‐term (TIR ARV) glycemic variability contribute to nerve dysfunction in T2D. High glycemic variability was linked to increased TCNS and altered nerve conduction. ABSTRACT Aims/Introduction Glycemic variability (GV) is a critical factor in the development of diabetic sensorimotor polyneuropathy (DSPN).
Yun‐Ru Lai, Wen‐Chan Chiu, Ben‐Chung Cheng, I‐Hsun Yu, Ting‐Yin Lin, Hui‐Ching Chiang, Chun‐En Aurea Kuo, Cheng‐Hsien Lu   +7 more
wiley   +1 more source