Results 111 to 120 of about 26,749 (243)

Fenugreek : a natural prototype oral hypoglycaemic agent used in Malta [PDF]

, 2009
Before the discovery of insulin therapy in 1921 and the development of effective oral hypoglycaemic therapy in 1926, pharmacological management of diabetes mellitus was restricted to empirical treatment often based on plant products and relegated to ...
Savona-Ventura, Charles
core  

Hypoglycaemia Risk Prediction Models for Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This systematic review and meta‐analysis evaluated existing hypoglycaemia risk prediction models for Type 2 diabetes, finding excellent pooled discrimination (AUC = 0.815) but widespread high methodological bias, highlighting the need for rigorous model optimisation and external validation.
Yiwen Wei, Yu Liu, Jingwen Bo, Xiaoyan Bai   +3 more
wiley   +1 more source

Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway

Cell Reports Medicine
Summary: The biguanide metformin attenuates mitochondrial oxidation and is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation and fatty acid β-oxidation (FAO) in a subgroup of patients with breast cancer (
Jun Hyoung Park, Kwang Hwa Jung, Dongya Jia, Sukjin Yang, Kuldeep S. Attri, Songyeon Ahn, Divya Murthy, Tagari Samanta, Debasmita Dutta, Meron Ghidey, Somik Chatterjee, Seung Yeop Han, Diego A. Pedroza, Abha Tiwari, Joyce V. Lee, Caitlin Davis, Shuting Li, Vasanta Putluri, Chad J. Creighton, Nagireddy Putluri, Lacey E. Dobrolecki, Michael T. Lewis, Jeffrey M. Rosen, José N. Onuchic, Andrei Goga, Benny Abraham Kaipparettu   +25 more
doaj   +1 more source

Solid Shampoo Is Mostly Not Preserved, in Contrast to Liquid Shampoos Used in Hairdressing—A Market Survey in Four European Countries

Contact Dermatitis, Volume 94, Issue 5, Page 524-530, May 2026.
Most solid shampoos (68.6%) did not contain preservatives according to Annex V of the EU Cosmetics Regulation (EC 1223/2009), while all liquid shampoos did. The number of preservatives used was significantly greater in liquid shampoos. ABSTRACT Background Hairdressers are frequently exposed to shampoos, both from neat liquid products and dilutions ...
Wolfgang Uter, Anders B. Funch, Mikkel Bak Jensen, Christoffer Kursawe Larsen, Ying X. Teo, Jeanne D. Johansen, Carola Lidén, Ian R. White   +7 more
wiley   +1 more source

Feed‐Forward Deep Neural Networks Predict Substrate‐Specific Effects of Transporter Variants to Explain Drug Response Variability

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Genetic variants in drug transporter genes shape the interindividual variability in drug response. However, their functional interpretation has remained limited due to the substrate dependence of variant effects. Existing predictors are substrate‐agnostic and cannot capture how a single amino acid change differentially affects transport across
Yoomi Park, Yitian Zhou, Ming Xiao, Anne T. Nies, Volker M. Lauschke   +4 more
wiley   +1 more source

Diabetes management in people undergoing metabolic‐bariatric surgery: A guideline from the Joint British Diabetes Societies for Inpatient Care (JBDS‐IP) Group

Diabetic Medicine, Volume 43, Issue 5, May 2026.
Abstract The global prevalence of obesity and diabetes continues to rise, with metabolic‐bariatric surgery recognised as an effective intervention for obesity and type 2 diabetes, offering potential for type 2 diabetes remission and improved glycaemic control. This guideline, developed by the Joint British Diabetes Societies for Inpatient Care (JBDS‐IP)
Jeffrey W. Stephens, Ketan Dhatariya, Andrew J. Beamish, Dimitri J. Pournaras, Alexander D. Miras, Nader Raafat, Georgia Noble‐Bell, Rachel Cadwallader Buckland, Omar G. Mustafa   +8 more
wiley   +1 more source

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis.

PLoS Biology, 2015
Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest as an antineoplastic agent. Recent work suggests that metformin directly antagonizes cancer cell growth through its actions on complex I of the mitochondrial ...
Takla Griss, Emma E Vincent, Robert Egnatchik, Jocelyn Chen, Eric H Ma, Brandon Faubert, Benoit Viollet, Ralph J DeBerardinis, Russell G Jones   +8 more
doaj   +1 more source

An audit to determine the clinical effectiveness of a pathway for managing wound infection [PDF]

, 2015
Prevention of wound infection is a key objective in the planning of care for patients with wounds. The potential for wound infection, particularly in chronic wounds that are heavily contaminated with bacteria, can be high (Bowler et al, 2001).
Grothier, Lorraine, Stephenson, John
core  

Real‐world predictors of progression to type 2 diabetes among adults with prediabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3985-3996, May 2026.
Abstract Aims Assess predictors of progression to type 2 diabetes (T2D) among patients with prediabetes. Materials and methods This case–control study assessed adults with prediabetes using US claims and EMR‐linked data from January 1, 2016, through January 31, 2024.
Tyler Dunn, Riddhi Doshi, Victoria Divino, Justin Chen, Michael Radin, Dajun Tian, Lin Xie, Carolina Solis‐Herrera   +7 more
wiley   +1 more source

Evaluating the Impact of Putative Metformin Targets on Cancer Outcomes: A Drug‐Target Mendelian Randomization Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4091-4099, May 2026.
ABSTRACT Aims Observational studies show metformin use associated with lower cancer risk, although experimental evidence is inconsistent. To provide genetic validation for repositioning of metformin in cancer prevention, we assessed genetically proxied effects of putative metformin targets on cancer outcomes using a drug‐target Mendelian randomization (
Xingyu Shen, Shan Luo, Jie Zheng, Celine Sze Ling Chui, Ian Chi Kei Wong, Eric Yuk Fai Wan, Catherine Mary Schooling, Shiu Lun Au Yeung   +7 more
wiley   +1 more source