Results 281 to 290 of about 27,566 (317)
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A direct access to heptasubstituted biguanides
Molecular Diversity, 2015An efficient and experimentally simple copper-catalyzed carbon-nitrogen bond formation for the synthesis of [Formula: see text]-arylated biguanides starting from aryl halides, carbodiimides, and 1,1,3,3-tetramethylguanidine is reported. The potential diversity of this type of reaction, easily available starting materials, and commercially available low-
Issa Yavari, Manijeh Nematpour
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Archiv der Pharmazie, 2019
Biguanides, including metformin and phenformin, have emerged as promising anticancer agents. However, the high dose needed for their efficient anticancer properties restricts their clinical application.
Sichun Zhou +12 more
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Biguanides, including metformin and phenformin, have emerged as promising anticancer agents. However, the high dose needed for their efficient anticancer properties restricts their clinical application.
Sichun Zhou +12 more
semanticscholar +1 more source
ChemInform Abstract: Structure of Various Biguanides and Metal Complexes of Biguanides
ChemInform, 1995AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Biguanides and Gastric Emptying in Man
Digestion, 1971In contrast to its effect in animal experiments, biguanide is shown to have no effect on gastric emptying in man.
W. Berger, M. Eisner
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Metformin: a new oral biguanide
Clinical Therapeutics, 1996The biguanide metformin is an oral anti-hyperglycemic agent used in the treatment of patients with non-insulin-dependent diabetes mellitus (NIDDM). Metformin is an important addition to the drug therapy options available for those patients because it reduces blood glucose levels predominantly by decreasing hepatic glucose production and release and ...
John R. White +2 more
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Effect of biguanides and atromid on fibrinolysis
Journal of Atherosclerosis Research, 1967Summary The effects of phenformin, metformin, and Atromid on blood fibrinolytic activity, plasma fibrinogen, and serum cholesterol levels were compared in a study of 36 out-patients with occlusive vascular disease. Atromid was the least satisfactory fibrinolytic drug, having only a transient effect on the blood clot lysis time, though a more ...
Elizabeth D. Hocking +3 more
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Biguanid-induzierte Laktatazidose
1995Es gibt Angaben, das das Risiko einer Laktatazidose unter Metformintherapie bei 0,024-0,084 Fallen pro 1000 Patientenjahre lage. Das entspricht 1:11000 bis 1:40 000 der Metformin-behandelten Patienten pro Jahr. Die Mortalitat ist nochmal um den Faktor 3 geringer. Die beschriebenen Todesfalle traten bei Patienten mit Kontraindikationen fur Metformin auf.
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