Results 101 to 110 of about 22,636 (317)

Metformin treatment for diabetes mellitus correlates with progression and survival in colorectal carcinoma [PDF]

, 2020
BACKGROUND: Diabetes mellitus is unfavorably associated with cancer risk. The purpose of this multi-disciplinary project was to evaluate a possible association of diabetes mellitus and other comorbidities and their treatment with progression of ...
Brown, Robert E., Cempírková, Dana, Dundr, Pavel, Gregorová, Jana, Grimmichová, Tereza, Heneberg, Petr, Janurová, Kateřina, Litschmannová, Martina, Pešta, Michal, Powell, Marta K., Třebický, Ferdinand   +10 more
core   +1 more source

Metformin reverses periodontal destruction caused by experimental periodontitis by inhibiting interleukin‐1β activity

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis is a destructive disease that affects periodontal tissue. While current research focuses on disease management, research on tissue repair remains limited. Metformin, a first‐line medication for diabetes treatment, has positive effects on bone health in nondiabetic patients.
Zhao Wang, Ju Han Song, Jung‐Woo Kim, Seung‐Hee Kwon, Xianyu Piao, Sin‐Hye Oh, Suk‐Gyun Park, Sun‐Hun Kim, Je‐Hwang Ryu, Ok‐Su Kim, Jeong‐Tae Koh   +10 more
wiley   +1 more source

Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production

Oxidative Medicine and Cellular Longevity, 2017
Metformin is widely prescribed as a first-choice antihyperglycemic drug for treatment of type 2 diabetes mellitus, and recent epidemiological studies showed its utility also in cancer therapy.
A. Pecinová, Z. Drahota, J. Kovalčíková, Nikola Kovářová, P. Pecina, L. Alán, M. Zima, J. Houštěk, T. Mráček   +8 more
semanticscholar   +1 more source

Antidiabetic effect of Tibetan medicine Tang-Kang-Fu-San on high-fat diet and streptozotocin-induced type 2 diabetic rats [PDF]

, 2017
The aim of this study was to investigate the antidiabetic effects of a Tibetan medicine, Tang-Kang-Fu-San (TKFS), on experimental type 2 diabetes mellitus (T2DM) rats and to explore its underlying mechanisms.
Duan, Bailu, Gao, Tiexiang, Jin, Jing, Lin, Ling, Mei, Zhinan, Ta, Na, Xiong, Hui, Zhang, Lijun, Zhao, Zhongqiu   +8 more
core   +3 more sources

Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility

Macromolecular Materials and Engineering, EarlyView.
Permanently implanted biomaterials are prone to attract microorganisms and thus represent niches for infections in vivo. Absorbable, antimicrobial polymers have emerged as a promising option. To improve the compatibility of adsorbable antimicrobial polymers with human cells, the block composition of the polycationic segment is modified regarding the ...
Cornelia Wolf‐Brandstetter, Rafael Methling, Dirk Kuckling   +2 more
wiley   +1 more source

Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. [PDF]

PLoS ONE, 2016
Hyperglycemia and hypertension impair endothelial function in part through oxidative stress-activated poly (ADP-ribose) polymerase 1 (PARP1). Biguanides and angiotensin II receptor blockers (ARBs) such as metformin and telmisartan have a vascular ...
Fenqing Shang, Jiao Zhang, Zhao Li, Jin Zhang, Yanjun Yin, Yaqiong Wang, Traci L Marin, Brendan Gongol, Han Xiao, You-Yi Zhang, Zhen Chen, John Y-J Shyy, Ting Lei   +12 more
doaj   +1 more source

Fenugreek : a natural prototype oral hypoglycaemic agent used in Malta [PDF]

, 2009
Before the discovery of insulin therapy in 1921 and the development of effective oral hypoglycaemic therapy in 1926, pharmacological management of diabetes mellitus was restricted to empirical treatment often based on plant products and relegated to ...
Savona-Ventura, Charles
core  

Genetic diversity of Acanthamoeba and clinical outcome predictors in Danish patients with Acanthamoeba keratitis

Acta Ophthalmologica, EarlyView.
Abstract Purpose Acanthamoeba keratitis (AK) is a severe corneal infection with potential detrimental effects on visual outcome and quality of life, primarily affecting young contact lens wearers. We report Acanthamoeba genotypes, subtypes and clinical outcome from Danish patients with AK. Methods Thirty‐nine PCR‐positive AK cases diagnosed and treated
Sandra M. Skovdal, Christen Rune Stensvold, Henrik Vedel Nielsen, Stine Elkjær Nielsen, Jesper Hjortdal, Anders Ivarsen   +5 more
wiley   +1 more source

A study of oral metformin for the intravesical treatment of non‐muscle‐invasive bladder cancer

BJU International, EarlyView.
Objectives To evaluate the effect of metformin on non‐muscle‐invasive bladder cancer (NMIBC) marker lesions. Patients and methods A phase II, open‐label, multicentre, marker lesion trial using oral metformin in patients with primary or recurrent, multiple, low‐grade Ta‐T1 NMIBC was conducted. After transurethral resection for histological confirmation,
Jons W. van Hattum, Marinka J. Remmelink, Sieb T. Nuijens, Ben Max de Ruiter, Gerrit K.J. Hooijer, Jorg R. Oddens, C. Dilara Savci‐Heijink, Ron Mathot, J. Alfred Witjes, Michael .N. Pollak, Theo M. de Reijke, Remco J. Molenaar, Hanneke W. Wilmink   +12 more
wiley   +1 more source

Prediction of glycaemic control and quality of life in people with type 2 diabetes using glucose‐lowering drugs with machine learning—The Maastricht study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Background Despite the heterogeneity of type 2 diabetes (T2D), all patients are treated according to the same guideline. Some people have more difficulty reaching treatment goals (adequate glycaemic control) and maintaining quality of life (QoL).
Nikki C. C. Werkman, Johannes T. H. Nielen, José Tapia‐Galisteo, Francisco J. Somolinos‐Simón, Maria Elena Hernando, Junfeng Wang, Li Jiu, Wim G. Goettsch, Hans Bosma, Miranda T. Schram, Marleen M. J. van Greevenbroek, Anke Wesselius, Coen D. A. Stehouwer, Johanna H. M. Driessen, Gema Garcia‐Sáez   +14 more
wiley   +1 more source