Results 281 to 290 of about 22,636 (317)
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Spectrophotometric (UV) investigation on biguanide and substituted biguanides
Tetrahedron, 1972Abstract Biguanide base and its monosalts have absorption maxima at 230 mμ which has been attributed to π-π* transition. The spectral effect on replacement of a carbon π centre by a heteroatom nitrogen centre is discussed and attempt has been made to predict the spectral shifts in biguanide base and normal salts due to the substitution heteronitrogen
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Ruthenium-catalyzed synthesis of arylethyl 1,3,5-triazines from arylallyl alcohols and biguanides.
Organic and biomolecular chemistry, 2018An efficient ruthenium-catalyzed synthesis of alkyl-1,3,5-triazies from arylallyl alcohols and biguanides has been developed. The reaction occurred in moderate to good yields and tolerated heterocyclic or aryl allyl alcohols containing functionalities ...
M. Zeng +3 more
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Specific Inhibition of Gluconeogenesis by Biguanides [PDF]
Nature, 1967 POSSIBLE schemes for the mechanism of the hypoglycaemic action of biguanides have raised considerable controversy in recent years. The possibility that these drugs may act through inhibition of oxidative phosphorylation, which may increase the glucose uptake of peripheral tissues1, has been frequently emphasized2–5, but experiments on the kinetics of ...
H. Clauser +2 more
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1996
The use of biguanides as oral antidiabetic agents has elicited considerable problems due to their lack of sufficient tolerability. The first derivative, phenylethylbiguanide (phenformin), was given marketing approval in the United States in 1957. Due to the serious side effects, however, the compound was withdrawn from the market in the United States ...
W. Rebel +3 more
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The use of biguanides as oral antidiabetic agents has elicited considerable problems due to their lack of sufficient tolerability. The first derivative, phenylethylbiguanide (phenformin), was given marketing approval in the United States in 1957. Due to the serious side effects, however, the compound was withdrawn from the market in the United States ...
W. Rebel +3 more
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ChemInform Abstract: Structure of Various Biguanides and Metal Complexes of Biguanides
ChemInform, 1995AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Biguanides and Gastric Emptying in Man
Digestion, 1971In contrast to its effect in animal experiments, biguanide is shown to have no effect on gastric emptying in man.
W. Berger, M. Eisner
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Biguanides: Species with versatile therapeutic applications.
European journal of medicinal chemistry, 2021Deepika Kathuria +3 more
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Ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides
, 2016An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated benzyl alcohol containing functionalities ...
Z. Ming +3 more
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Metformin: a new oral biguanide
Clinical Therapeutics, 1996The biguanide metformin is an oral anti-hyperglycemic agent used in the treatment of patients with non-insulin-dependent diabetes mellitus (NIDDM). Metformin is an important addition to the drug therapy options available for those patients because it reduces blood glucose levels predominantly by decreasing hepatic glucose production and release and ...
John R. White +2 more
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Biguanides, anion receptors and sensors.
Chemical Communications, 2017Biguanides are strong bases (pKa > 10), their protonated forms bind anions and may therefore act as receptors for anions. We report on easy-to-make anion receptors and fluorescence-based sensors utilizing the biguanide moieties that respond to the ...
M. Pushina, P. Anzenbacher
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