Results 1 to 10 of about 1,307,425 (404)

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

Nature, 2020
The gut microbiota synthesize hundreds of molecules, many of which influence host physiology. Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at concentrations of around
Tyler L Grove, Min Wang, Molly E Mcfadden   +2 more
exaly   +2 more sources

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Nature
Bacteria in the gastrointestinal tract produce amino acid bile acid amidates that can affect host-mediated metabolic processes1–6; however, the bacterial gene(s) responsible for their production remain unknown. Herein, we report that bile salt hydrolase (
Stephanie Collins, Imhoi Koo, Fuhua Hao
exaly   +2 more sources

Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

Signal Transduction and Targeted Therapy
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro-inflammatory/anti-inflammatory balance.

exaly   +2 more sources

Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism

Nature Communications, 2019
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea.
Xiaojiao Zheng, Runqiu Jiang, Yunjing Zhang   +2 more
exaly   +2 more sources

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

Science, 2018
Chi Ma, Miaojun Han, Bernd Heinrich
exaly   +2 more sources

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Nature Medicine, 2019
Lulu Sun, Frank J Gonzalez, Andrew D Patterson   +2 more
exaly   +2 more sources

Bile acids as modulators of gut microbiota composition and function

Gut microbes, 2023
Changes in the composition of gut-associated microbial communities are associated with many human illnesses, but the factors driving dysbiosis remain incompletely understood. One factor governing the microbiota composition in the gut is bile.
Anaïs Larabi, Hugo L. P. Masson, A. Bäumler   +2 more
semanticscholar   +1 more source

Household Dietary Diversity and Associated Factors among Rural Residents of Gomole District, Borena Zone, Oromia Regional State, Ethiopia

Health Services Research & Managerial Epidemiology, 2022
Background Low dietary diversity is the main public health issue in developing countries. Despite its burden, there is a paucity of information on the dietary diversity of households and related factors in rural residents of southern Ethiopia. Therefore,
Alqeer Aliyo, Wako Golicha, Anteneh Fikrie   +2 more
doaj   +1 more source

Gut microbiota Turicibacter strains differentially modify bile acids and host lipids

bioRxiv, 2023
Bacteria from the Turicibacter genus are prominent members of the mammalian gut microbiota and are associated with alterations in dietary fat and body weight, but the specific connections between these symbionts and host physiology are poorly understood.
J. Lynch, E. L. González, K. Choy, K. Faull, T. Jewell, Abelardo Arellano, Jennifer Liang, Kristie B. Yu, J. Paramo, E. Hsiao   +9 more
semanticscholar   +1 more source

Sarcopenia as a predictor of postoperative complications in patients with pancreatic cancer

Medičnì Perspektivi, 2021
Several studies showed that sarcopenia is associated with an increase of postoperative complications, with worse postoperative results in patients with pancreatic cancer.
V.M. Kopchak, L.O. Pererva, V.P. Shkarban, V.I. Trachuk, S.V. Lynnyk   +4 more
doaj   +1 more source