Results 91 to 100 of about 5,534,791 (400)

Enhanced PDMS Functionalization for Organ‐on‐a‐Chip Platforms Using Ozone and Sulfo‐SANPAH: A Simple Approach for Biomimetic Long‐Term Cell Cultures

Advanced Healthcare Materials, EarlyView.
The use of organ‐on‐a‐chip (OOC) microfluidic platforms is expanding in biomedical research. While this emerging technology is becoming increasingly accessible, the stability of long‐term functional cultures remains a critical challenge to address. This study presents a straightforward, one‐step method for the functionalization of polydimethylsiloxane ...
Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Alyssa Shapiro, Lazaro Huerta, Mathieu Hautefeuille, Marina Macías‐Silva, Daniel Pérez‐Calixto, Genaro Vázquez‐Victorio   +7 more
wiley   +1 more source

Versatile application of fast green FCF as a visible cholangiogram in adult mice to medium-sized mammals

Scientific Reports
An aqueous solution of a common food dye, Fast Green FCF (FG), mimics cholyl-lysyl-fluorescein to visualize embryonic bile flow via single peritoneal injection into intrauterine mouse embryos.
Tomoyuki Niimi, Nanae Miyazaki, Hironobu Oiki, Mami Uemura, Shihan Zeng, Watcharapon Promsut, Noriaki Ota, Shunji Nonaka, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Ayaka Yanagida, Ryuji Hiramatsu, Masami Kanai-Azuma, Shohei Takami, Jun Fujishiro, Yoshiakira Kanai   +16 more
doaj   +1 more source

Strain differences in deconjugation of bile acids in Bifidobacterium pseudocatenulatum isolates [PDF]

, 2004
The survival and growth rate of twenty eight isolates of bifidobacteria in bile were evaluated. Of 28 isolates, 25 were tolerance towards 2.0% concentration of bile while 14 isolates were tolerance towards 4.0% of bile after 12 hours of exposure.
Abd Manap, Mohd Yazid, Abdullah, Nur Atiqah, Ali, Abdul Manaf, Lim, Long Chang, Mustafa, Shuhaimi, Sabet, Maryam Rezaei, Sipat, Abdullah, Syed Muhammad, Sharifah Kharidah, Yap, Keng Wai   +8 more
core   +1 more source

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

bioRxiv, 2019
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout the body, including the CNS and immune system.
P. Bhargava, Leah Mische, Matthew D. Smith, Emily P. Harrington, K. Fitzgerald, Kyle A. Martin, Sol Kim, A. A. Reyes, Jaime Gonzalez-Cardona, Christina M. Volsko, Sonal Singh, Kesava Varanasi, Elias S. Sotirchos, B. Nourbakhsh, Ranjan Dutta, E. Mowry, E. Waubant, P. Calabresi   +17 more
semanticscholar   +1 more source

A Highly Adaptable Hydrogen Bond Re‐Orientation (HyBRO) Strategy for Multiscale Vasculature Fabrication

Advanced Materials, EarlyView.
A novel hydrogen bond re‐orientation (HyBRO) strategy enables three‐dimensional (3D) printing of vascular microchannel networks with high accuracy. By switching sacrificial material interactions with nonsolvents, HyBRO prevents swelling and deformation, enabling accurate hierarchical channels spanning a tenfold size range.
Zhencheng Liao, Yu Liu, Chonghao Chen, Iek Man Lei, Lei Dong, Chunming Wang   +5 more
wiley   +1 more source

Bile Acids: Major Regulator of the Gut Microbiome

Microorganisms, 2022
Bile acids are synthesized from cholesterol and play an important role in regulating intestinal microflora. The different degrees of hydrophobicity and acidity of individual bile acids may affect their antimicrobial properties.
Chihyeok An, Hyeyeon Chon, Wanrim Ku, Sunho Eom, Mingyu Seok, Sangha Kim, Jaesun Lee, Daesung Kim, Sanghyuk Lee, Hoonsup Koo, Hyunjung Cho, Seungyun Han, Juik Moon, Miil Kang, Kihyun Ryu   +14 more
doaj   +1 more source

Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets

Diabetes & Metabolism Journal, 2019
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in
Jessica M. Ferrell, J. Chiang
semanticscholar   +1 more source

Polymer Nanogels with Albumin Reporting Interface Created Using RAFT Precipitation Polymerization for Disease Diagnosis and Food Testing

Advanced Materials Interfaces, EarlyView.
Herein, polymer nanogels with a reporting interface for albumin are synthesized through reversible addition–fragmentation chain transfer (RAFT) precipitation polymerization of di(ethylene glycol) methyl ether methacrylate and N,N’‐methylenebis(acrylamide) using a poly(2‐methacryloyloxyethyl phosphorylcholine) macro‐RAFT agent, followed by dansyl ...
Yukiya Kitayama, Erika Yoshimatsu, Atsushi Harada   +2 more
wiley   +1 more source

Paclitaxel chemotherapy disrupts microbiota-enterohepatic bile acid metabolism in mice

Gut Microbes
Balanced interactions between the enteric microbiota and enterohepatic organs are essential to bile acid homeostasis, and thus normal gastrointestinal function.
Brett R. Loman, Zainab Alzoubi, Alexis J. Lynch, Robert M. Jaggers, Kelley Jordan, Corena V. Grant, Lynette K. Rogers, Leah M. Pyter, Michael T. Bailey   +8 more
doaj   +1 more source

Deficiency of Capicua disrupts bile acid homeostasis [PDF]

, 2018
Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown.
Choi, N, Fryer, JD, Hwang, D, Jung, HY, Kang, H, Kim, E, KIM, KYONG TAI, Kim, S, Lee, J, LEE, YOONTAE, Park, S, Yoe, J, Zoghbi, HY   +12 more
core   +2 more sources