Results 101 to 110 of about 354,033 (333)

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium

Journal of Lipid Research, 2012
The human bile acid pool composition is composed of both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid).
Jason M. Ridlon, Phillip B. Hylemon
doaj  

Stereochemical Course of the Conversion of Cholesterol to Bile Acid. [PDF]

, 1959
S. Bergström, Bertil Samuelsson, H. Thommen, Susanne Refn   +3 more
openalex   +1 more source

In Situ Assembly of Fluorogenic RNA for Screening Natural Anti‐Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA

Advanced Science, EarlyView.
This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai, Li‐Zeng Zhu, Changfa Shao, Zheng Yin, Qun Liu, Yu Gu, Bin Liu   +6 more
wiley   +1 more source

Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment.

Journal of Lipid Research, 1989
We have studied the effect of ursodeoxycholic acid on the serum and urinary bile acids in seven patients with moderate to severe primary biliary cirrhosis.
A K Batta, R Arora, G Salen, G S Tint, D Eskreis, S Katz   +5 more
doaj  

Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives [PDF]

, 2018
In this work we present an efficient, environmentally friendly approach to the synthesis of a series of hyodeoxycholic acid derivatives applying Biocatalysis.
Baldessari, Alicia, Chanquia, Santiago Nahuel, Garcia Liñares, Guadalupe Eugenia, Ripani, Erika Aldana   +3 more
core   +1 more source

Bile Acids

Journal of Biological Chemistry, 1971
Abstract 3β-3H-Allochenodeoxycholic acid was administered by stomach tube to rats with bile fistulas. Bile collected during the first 21 hours contained 53 to 59% of the administered 3H. After hydrolysis and separation of the free bile acids by acetic acid partition chromatography, 95% of the chromatographed 3H was recovered as the unchanged acid, but ...
Mei Mei Mui, William H. Elliott
openaire   +4 more sources

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

Study of the baiE Gene in Bile Acid 7α-Dehydroxylating Bacteria [PDF]

, 1998
Intestinal bile acid 7α-dehydroxylating bacteria have recently been implicated in cholesterol allstone disease. Eubacterium sp. V.P.I. 12708, a bile acid 7α-dehydroxylating bacterium, contains multiple bile acid inducible (bai) genes which encode the ...
Kaya, Yasemin
core   +1 more source

Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. [PDF]

, 2015
Background & aimsAll-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration.
Hu, Ying, Liu, Hui-Xin, Wan, Yu-Jui Yvonne   +2 more
core   +2 more sources