Results 101 to 110 of about 5,534,791 (400)

MRGPRX4 is a bile acid receptor for human cholestatic itch

eLife, 2019
Patients with liver diseases often suffer from chronic itch, yet the pruritogen(s) and receptor(s) remain largely elusive. Here, we identify bile acids as natural ligands for MRGPRX4.
Huasheng Yu, Tianjun Zhao, Simin Liu, Qinxue Wu, Omar Johnson, Zhaofa Wu, Zihao Zhuang, Yaocheng Shi, Luxin Peng, Renxi He, Yong Yang, Jianjun Sun, Xiaoqun Wang, Haifeng Xu, Z. Zeng, Peng Zou, Xiaoguang Lei, Wenqin Luo, Yulong Li   +18 more
semanticscholar   +1 more source

Electrophotographic Powder Application for Surface Functionalization of Polymer Parts with Thin Silver‐Nanoadditivated Bactericidal Layers

Advanced Materials Technologies, EarlyView.
Polyamide 12 powder nanoadditivated with laser‐synthesized silver nanoparticles is deposited and sintered on polymer parts via EPA‐PBF‐LB/P. The thin surface coating (140 µm) inhibits E. coli and S. aureus bacteria growth and significantly increases the UV light absorption, whereas the mechanical and thermal properties remain unchanged due to minimal ...
Jan Lino Kricke, Niklas Ebert, Ane Sorarrain, Stephan Roth, Dagmar Fischer, Michael Schmidt, Bilal Gökce, José María Marimón, Sebastian‐Paul Kopp, Carlos Doñate‐Buendía   +9 more
wiley   +1 more source

Bile Acid Analysis in Biliary Tract Cancer [PDF]

, 2006
The etiology of biliary tract cancer is obscure, but there are evidences that bile acid plays a role in carcinogenesis. To find the association between biliary tract cancer and bile acid, this study compared the bile acid concentration and composition ...
Antsaklis, Barone, Bolder, Byung Kyu Park, Cameron, Castleden, Cohn, Einarsson, Funabiki, Holzinger, Hong, Ikematsu, Jae Bock Chung, Javitt, Jeong Youp Park, Jun Sang Ko, Kinami, Kinami, Kinugasa, Lee, Lee, Makino, Nagengast, Oyama, Paulusma, Seungmin Bang, Shoda, Si Young Song, Strom, Thompson, Tocchi, Trauner, Trauner   +32 more
core   +2 more sources

Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study.

Journal of the National Cancer Institute, 2019
BACKGROUND Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans.
T. Kühn, M. Stepien, M. López‐Nogueroles, A. Damms-Machado, D. Sookthai, T. Johnson, M. Roca, A. Hüsing, S. G. Maldonado, A. Cross, N. Murphy, H. Freisling, S. Rinaldi, A. Scalbert, V. Fedirko, G. Severi, M. Boutron‐Ruault, F. Mancini, Solomon A. Sowah, H. Boeing, P. Jakszyn, María-José Sánchez, S. Merino, S. Colorado-Yohar, A. Barricarte, K. Khaw, Julie A. Schmidt, A. Perez-Cornago, A. Trichopoulou, A. Karakatsani, P. Thriskos, D. Palli, C. Agnoli, R. Tumino, C. Sacerdote, S. Panico, B. Bueno-de-Mesquita, C. V. van Gils, A. Heath, M. Gunter, E. Riboli, A. Lahoz, M. Jenab, R. Kaaks   +43 more
semanticscholar   +1 more source

Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis

Advanced Science, EarlyView.
An unprecedented high‐resolution spatial atlas of the E. multilocularis infection foci is obtained, revealing the dynamic functions of neutrophils, Spp1+ macrophages, and fibroblasts during disease progression. The transition of parasite control strategy from “active killing” to “negative segregation” by the host may provide instructive insights into ...
Zhihua Ou, Li Li, Peidi Ren, Ting‐Ting Zhou, Fan He, Jialing Chen, Huimin Cai, Xiumin Han, Yao‐Dong Wu, Jiandong Li, Xiu‐Rong Li, Qiming Tan, Wenhui Li, Qi Chen, Nian‐Zhang Zhang, Xiuju He, Wei‐Gang Chen, Yanping Zhao, Jiwen Sun, Qian Zhang, Yan‐Tao Wu, Yingan Liang, Jie You, Guohai Hu, Xue‐Qi Tian, Sha Liao, Bao‐Quan Fu, Ao Chen, Xue‐Peng Cai, Huanming Yang, Jian Wang, Xin Jin, Xun Xu, Wan‐Zhong Jia, Junhua Li, Hong‐Bin Yan   +35 more
wiley   +1 more source

Bile acids drive chemotaxis of Clonorchis sinensis juveniles to the bile duct. [PDF]

PLoS Neglected Tropical Diseases, 2018
Clonorchiasis is a neglected tropical disease caused by Chinese liver fluke, Clonorchis sinensis infection. C. sinensis is a biological carcinogen causing cholangiocarcinoma in humans. In the mammalian host, C.
Shunyu Li, Won Gi Yoo, Jin-Ho Song, Tae Im Kim, Sung-Jong Hong   +4 more
doaj   +1 more source

Very long O-antigen chains enhance fitness during Salmonella-induced colitis by increasing bile resistance. [PDF]

, 2012
Intestinal inflammation changes the luminal habitat for microbes through mechanisms that have not been fully resolved. We noticed that the FepE regulator of very long O-antigen chain assembly in the enteric pathogen Salmonella enterica serotype ...
Bäumler, Andreas J, Crawford, Robert W, Keestra, A Marijke, Tolstikov, Vladimir, Tsolis, Renée M, Winter, Sebastian E, Xavier, Mariana N   +6 more
core  

Rethinking the bile acid/gut microbiome axis in cancer [PDF]

, 2017
Dietary factors, probiotic agents, aging and antibiotics/medicines impact on gut microbiome composition leading to disturbances in localised microbial populations.
Caparros-Martin, Jose A., O'Connor, Rosemary, O'Gara, Fergal, Phelan, John P., Reen, F. Jerry   +4 more
core   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source