Results 91 to 100 of about 32,242 (265)

Bile acid-induced lung injury: update of reverse translational biology

, 2022
The presence of bile acids in lung tissue is associated with some clinical features observed in various medical specialties, but it took time to understand that these are due to a “bile acid-induced lung injury” since specific translational studies and ...
Alonso, Alejandro, De luca, Daniele, Autilio, Chiara   +2 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Estimation of bile acid pool sizes from their spillover into systemic blood.

Journal of Lipid Research, 1985
We have examined the possibility of assessing primary bile acid pool sizes from the spillover of the bile acids into systemic blood after intestinal exposure to the total endogenous bile acid pool; the studies were carried out in 16 healthy subjects ...
S D van der Werf, G P van Berge Henegouwen, W van den Broek   +2 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Comparative genomics of lactic acid bacteria reveals a niche-specific gene set

, 2009
peer-reviewedBackground: The recently sequenced genome of Lactobacillus helveticus DPC4571 1 revealed a dairy organism with significant homology (75% of genes are homologous) to a probiotic bacteria Lb. acidophilus NCFM 2. This led us to hypothesise that
O\u27Callaghan, John, Callanan, Michael J., Fitzgerald, Gerald F, Gerald F Fitzgerald, Sangrador-Vegas, Amaia, Kaleta Pawel, O'Callaghan John, O'Sullivan, Orla, Fitzgerald Gerald F, Callanan Michael, O\u27Sullivan, Orla, Ross, R. Paul, Fitzgerald, Gerald F., Michael Callanan, O'Callaghan, John, Tom Beresford, Orla O'Sullivan, O'Sullivan Orla, Beresford, Thomas P., John O'Callaghan, Ross R Paul, Kaleta, Pawel, McAuliffe Olivia, Beresford, Tom, Olivia McAuliffe, Lydia Slattery, Amaia Sangrador-Vegas, McAuliffe, Olivia, Slattery Lydia, Pawel Kaleta, R Paul Ross, Slattery, Lydia, Beresford Tom, Ross, R Paul, Callanan, Michael, Sangrador-Vegas Amaia   +35 more
core   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Dietary bile acids alleviate dextran sulfate sodium-induced enteritis in juvenile leopard coral grouper (Plectropomus leopardus)

Aquaculture Reports
Enteritis is a common disease in leopard coral grouper reared under intensive aquaculture conditions. We developed an enteritis model by feeding fish with 0.75 % dextran sulfate sodium (DSS) diet for one week, followed by a three-week period with diets ...
Shengpeng Wang, Longting Zhang, Jie Huang, Qingcong Fu, Dingqian Guo, Yujie Gao   +5 more
doaj   +1 more source

Research Progress in Bile Acid Receptor-Mediated Improvement of Intestinal Health by Natural Products [PDF]

Shipin Kexue
Bile acids play an important role in intestinal health, and an imbalance in bile acid homeostasis is closely related to intestinal diseases such as inflammatory bowel disease, irritable bowel syndrome, bile acid diarrhea, and colorectal cancer.
LIU Qi, CHEN Siyang, HAN Xiaoqian, LI Shuting, HAN Feifei
doaj   +1 more source

Bile Acid Diarrhea

The Korean Journal of Gastroenterology
Diarrhea is a very common gastrointestinal symptom, and the presence of higher concentrations of bile acid in the colon leads to bile acid diarrhea (BAD). In BAD patients, a portion of bile from the small intestine that is normally controlled by enterohepatic circulation is present at a high concentration in the lumen of the large intestine, resulting ...
Hee Jin Kim, Hyun Jin Kim
openaire   +3 more sources