Results 1 to 10 of about 3,456,901 (302)

Bile acid metabolism and signaling in liver disease and therapy

Liver Research, 2017
Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5).
John Y.L. Chiang
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Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle

Animals, 2022
Myostatin (MSTN) is a major negative regulator of skeletal muscle mass and causes a variety of metabolic changes. However, the effect of MSTN knockout on bile acid metabolism has rarely been reported.
Di Wu, Mingjuan Gu, Zhuying Wei, Chunling Bai, Guanghua Su, Xuefei Liu, Yuefang Zhao, Lei Yang, Guangpeng Li   +8 more
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Recapitulation of bile acid metabolism in hepatobiliary organoids derived from hiPSC [PDF]

JHEP Reports
Background & Aims: Bile acids are crucial mediators of cholesterol homeostasis, lipid digestion, and detoxification, and reliable in vitro synthesis systems are essential for liver disease research and precision medicine.
Junming Xu, Xiaopu Sang, Jie Ke, Jingyi Li, Jiasen Xu, Xiaoni Chen, Shan Lin, Ruijie Cai, Xianjie Shi, Fenfang Wu   +9 more
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The 7-α-dehydroxylation pathway: An integral component of gut bacterial bile acid metabolism and potential therapeutic target

Frontiers in Microbiology, 2023
The gut microbiome plays a significant role in maintaining host metabolic health through the production of metabolites. Comprising one of the most abundant and diverse forms of gut metabolites, bile acids play a key role in blood glucose regulation ...
Journey L. Wise, Bethany P. Cummings
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Ferulic Acid Alleviates Lipid and Bile Acid Metabolism Disorders by Targeting FASN and CYP7A1 in Iron Overload-Treated Mice

Antioxidants
Iron overload is a common complication in various chronic liver diseases, including non-alcoholic fatty liver disease (NAFLD). Lipid and bile acid metabolism disorders are regarded as crucial hallmarks of NAFLD.
Yaxu Liang, Jun Qi, Dongming Yu, Zhibo Wang, Weite Li, Fei Long, Shuai Ning, Meng Yuan, Xiang Zhong   +8 more
doaj   +3 more sources

Bile Acid Detection Techniques and Bile Acid-Related Diseases

Frontiers in Physiology, 2022
Bile acid is a derivative of cholinergic acid (steroidal parent nucleus) that plays an important role in digestion, absorption, and metabolism. In recent years, bile acids have been identified as signaling molecules that regulate self-metabolism, lipid ...
Xiang Zhao, Zitian Liu, Fuyun Sun, Lunjin Yao, Guangwei Yang, Kexin Wang   +5 more
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UPLC-Q-TOF/MS-based metabonomics reveals mechanisms for Holothuria leucospilota polysaccharides (HLP)-regulated serum metabolic changes in diabetic rats

Food Chemistry: X, 2023
This study aimed to use metabolomic methods to explore how Holothuria leucospilota polysaccharides (HLP) improved metabolism disorders in the liver of Goto-Kakizaki (GK) rats with spontaneous type 2 diabetes.
Xin Zhang, Fuqiang Zhao, Tingting Ma, Yuanping Zheng, Jun Cao, Chuan Li, Kexue Zhu   +6 more
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A Retrospective Clinical Analysis of the Serum Bile Acid Alteration Caused by Traumatic Brain Injury

Frontiers in Neurology, 2021
Traumatic brain injury (TBI) can cause damage to peripheral organ systems, such as digestive organ system, and alterations of gut microbiota in addition to brain injury.
Yuanrun Zhu, Zijian Chen, Zijian Chen, Wendong You, Yadong Wang, Mengdi Tu, Peidong Zheng, Liang Wen, Xiaofeng Yang   +8 more
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Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice[S]

Journal of Lipid Research, 2014
Vitamin D receptor (VDR) mediates vitamin D signaling involved in bone metabolism, cellular growth and differentiation, cardiovascular function, and bile acid regulation.
Jie Cheng, Zhong-Ze Fang, Jung-Hwan Kim, Kristopher W. Krausz, Naoki Tanaka, JohnY.L. Chiang, Frank J. Gonzalez   +6 more
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Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice

Hepatology Communications, 2022
Bile acid‐CoA: amino acid N‐acyltransferase (BAAT) catalyzes bile acid conjugation, the last step in bile acid synthesis. BAAT gene mutation in humans results in hypercholanemia, growth retardation, and fat‐soluble vitamin insufficiency.
Bandar D. Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A. J. Trammell, Trisha J. Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D. Patterson, John Y. L. Chiang, Frank J. Gonzalez, Yoon‐Kwang Lee   +15 more
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