Results 11 to 20 of about 3,456,901 (302)
In Silico Analysis Identifies Intestinal Transit as a Key Determinant of Systemic Bile Acid Metabolism [PDF]
Frontiers in Physiology, 2018 Bile acids fulfill a variety of metabolic functions including regulation of glucose and lipid metabolism. Since changes of bile acid metabolism accompany obesity, Type 2 Diabetes Mellitus and bariatric surgery, there is great interest in their role in ...
Fianne L. P. Sips +7 more
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Role of CYP27A in cholesterol and bile acid metabolism [PDF]
Journal of Lipid Research, 2005 The CYP27A gene encodes a mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase, that is expressed in many different tissues and plays an important role in cholesterol and bile acid metabolism. In humans, CYP27A deficiency leads to cerebrotendinous
Sandrine Dubrac +14 more
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Intestinal transport and metabolism of bile acids [PDF]
Journal of Lipid Research, 2015 In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G protein-coupled receptors to regulate a myriad of cellular
Paul A. Dawson, Saul J. Karpen
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Bile acids and metabolic surgery
Liver Research, 2021 The epidemic of obesity and its co-mortalities has reached an alarming level worldwide. Currently, metabolic surgeries, especially the Roux-en-Y gastric bypass and vertical sleeve gastrectomy, are the most effective and sustainable treatments for obesity, type 2 diabetes, non-alcoholic steatohepatitis, as well as other metabolic diseases.
Hui Xue +4 more
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Bile acids as metabolic regulators [PDF]
Current Opinion in Gastroenterology, 2015 This review focuses on the latest understanding of the molecular mechanisms underlying the complex interactions between intestine and liver bile acid signaling, gut microbiota, and their impact on whole-body lipid, glucose and energy metabolism.Hepatic bile acid synthesis is tightly regulated by the bile acid negative feedback mechanisms.
Tiangang, Li, John Y L, Chiang
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Metabolic Messengers: bile acids
Nature Metabolism, 2022 Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on both host and microbial metabolism. These metabolites have emerged as biologically active signalling molecules that inform organs of nutrient availability. Their actions, through activation of the dedicated BA receptors FXR and TGR5, control the body's integrated ...
Perino, Alessia, Schoonjans, Kristina
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Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]
, 2004 Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Thiessen, K. +5 more
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Inborn Errors of Bile Acid Metabolism [PDF]
Seminars in Liver Disease, 2007 Inborn errors of bile acid metabolism are rare causes of neonatal cholestasis and liver disease in older children and adults. The diagnosis should be considered in the context of hyperbilirubinemia with normal serum bile acids and made by urinary liquid secondary ionization mass spectrometry or DNA testing. Cholic acid is an effective treatment of most
James E, Heubi +2 more
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New synthetic bile acid analogue agonists of FXR and TGR5 receptors: Analytical methodologies for the study of their physico-chemical properties, pharmacokinetic activity and metabolism. [PDF]
, 2013 This thesis reports an integrated analytical approach for the study of physicochemical and biological properties of new synthetic bile acid (BA) analogues agonists of FXR and TGR5 receptors.
Colliva, Carolina <1981>
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A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Albert K. Groen +12 more
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