Results 31 to 40 of about 3,456,901 (302)

Inflammation‐induced cholestasis in cancer cachexia

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Cancer cachexia is a debilitating metabolic syndrome contributing to cancer death. Organs other than the muscle may contribute to the pathogenesis of cancer cachexia.
Morgane M. Thibaut, Martina Sboarina, Martin Roumain, Sarah A. Pötgens, Audrey M. Neyrinck, Florence Destrée, Justine Gillard, Isabelle A. Leclercq, Guillaume Dachy, Jean‐Baptiste Demoulin, Anne Tailleux, Sophie Lestavel, Marialetizia Rastelli, Amandine Everard, Patrice D. Cani, Paolo E. Porporato, Audrey Loumaye, Jean‐Paul Thissen, Giulio G. Muccioli, Nathalie M. Delzenne, Laure B. Bindels   +20 more
doaj   +1 more source

Comparative genomics of lactic acid bacteria reveals a niche-specific gene set [PDF]

, 2009
peer-reviewedBackground: The recently sequenced genome of Lactobacillus helveticus DPC4571 1 revealed a dairy organism with significant homology (75% of genes are homologous) to a probiotic bacteria Lb. acidophilus NCFM 2. This led us to hypothesise that
O\u27Callaghan, John, Callanan, Michael J., Fitzgerald, Gerald F, Gerald F Fitzgerald, Sangrador-Vegas, Amaia, Kaleta Pawel, O'Callaghan John, O'Sullivan, Orla, Fitzgerald Gerald F, Callanan Michael, O\u27Sullivan, Orla, Ross, R. Paul, Fitzgerald, Gerald F., Michael Callanan, O'Callaghan, John, Tom Beresford, Orla O'Sullivan, O'Sullivan Orla, Beresford, Thomas P., John O'Callaghan, Ross R Paul, Kaleta, Pawel, McAuliffe Olivia, Beresford, Tom, Olivia McAuliffe, Lydia Slattery, Amaia Sangrador-Vegas, McAuliffe, Olivia, Slattery Lydia, Pawel Kaleta, R Paul Ross, Slattery, Lydia, Beresford Tom, Ross, R Paul, Callanan, Michael, Sangrador-Vegas Amaia, O'Sullivan, Orla, O'Callaghan, John   +37 more
core   +1 more source

Navigating cholestasis: identifying inborn errors of bile acid metabolism for precision diagnosis

Frontiers in Pediatrics
Inborn errors of bile acid metabolism (IEBAM) cause cholestasis during the neonatal period, and 8 types of IEBAM have been reported to date. IEBAM accounts for approximately 2% of cases of cholestasis of unknown cause.
Hiroshi Nittono, Mitsuyoshi Suzuki, Hiromi Suzuki, Hiromi Suzuki, Satoru Sugimoto, Jun Mori, Rieko Sakamoto, Yugo Takaki, Hisamitsu Hayashi, Hajime Takei, Akihiko Kimura   +10 more
doaj   +1 more source

Intrauterine growth retardation affects liver bile acid metabolism in growing pigs: effects associated with the changes of colonic bile acid derivatives

Journal of Animal Science and Biotechnology, 2022
Background Intrauterine growth retardation (IUGR) is associated with severely impaired nutrient metabolism and intestinal development of pigs. Our previous study found that IUGR altered intestinal microbiota and metabolites in the colon.
Yang Liu, Md. Abul Kalam Azad, Wanghong Zhang, Liang Xiong, Francois Blachier, Zugong Yu, Xiangfeng Kong   +6 more
doaj   +1 more source

Improved annotation of conjugated bile acid hydrolase superfamily members in Gram-positive bacteria. [PDF]

, 2008
Contains fulltext : 69805.pdf (Publisher’s version ) (Closed access)Most Gram-positive bacteria inhabiting the gastrointestinal tract are capable of hydrolysing bile salts.
Lambert, J.M., Vos, W.M., de, Kleerebezem, M., Siezen, R.J., Vos, W.M. de, de Vos, W.M.   +5 more
core   +2 more sources

Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota

Genome Biology, 2023
Background Caloric restriction (CR) has been known to promote health by reprogramming metabolism, yet little is known about how the epigenome and microbiome respond during metabolic adaptation to CR.
Yun Fan, Hong Qian, Meijia Zhang, Chengzhe Tao, Zhi Li, Wenkai Yan, Yuna Huang, Yan Zhang, Qiaoqiao Xu, Xinru Wang, Paul A. Wade, Yankai Xia, Yufeng Qin, Chuncheng Lu   +13 more
doaj   +1 more source

Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease [PDF]

, 1992
Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary ...
Sven Fischer, Seifferth, Bernd, Paumgartner, Gustav, Holl, Joseph, Frieder Berr, Werner Richter, Joseph Holl, Bernd Seifferth, Jüngst, Dieter, Dieter Jongst, Berr, Frieder, Richter, Werner O., Fischer, Sven, Gustav Paumgartner   +13 more
core   +1 more source

Effect of phospholipids and bile acids on cholesterol nucleation time and vesicular/micellar cholesterol in gallbladder bile of patients with cholesterol stones [PDF]

, 1993
Supersaturation and rapid nucleation of cholesterol in bile are of key importance in the pathogenesis of cholesterol gallstones. While the effects of bile acids and phospholipids on cholesterol saturation of bile have been extensively studied, their ...
Paumgartner, Gustav, Lange, V., Jüngst, Dieter, Huber, P., Lang, Thomas   +4 more
core   +1 more source

Systematic identification of secondary bile acid production genes in global microbiome

mSystems
Microbial metabolism of bile acids (BAs) is crucial for maintaining homeostasis in vertebrate hosts and environments. Although certain organisms involved in bile acid metabolism have been identified, a global, comprehensive elucidation of the microbes ...
Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao   +11 more
doaj   +1 more source

Functional analysis of four bile salt hydrolase and penicillin acylase family members in Lactobacillus plantarum WCFS1 [PDF]

, 2008
Bile salts play an important role in the digestion of lipids in vertebrates and are synthesized and conjugated to either glycine or taurine in the liver.
Lambert, J.M., Vos, W.M., de, Kleerebezem, M., Bongers, R.S., de Vos, W.M.   +4 more
core   +1 more source