Results 51 to 60 of about 3,456,901 (302)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Paclitaxel chemotherapy disrupts microbiota-enterohepatic bile acid metabolism in mice

Gut Microbes
Balanced interactions between the enteric microbiota and enterohepatic organs are essential to bile acid homeostasis, and thus normal gastrointestinal function.
Brett R. Loman, Zainab Alzoubi, Alexis J. Lynch, Robert M. Jaggers, Kelley Jordan, Corena V. Grant, Lynette K. Rogers, Leah M. Pyter, Michael T. Bailey   +8 more
doaj   +1 more source

Taurine-conjugated bile acids are the predominant form in hens and have potential impact on lipid metabolism in the liver

Italian Journal of Animal Science, 2023
In mammals, bile acids composition varies with species, age, physiological conditions. However, the role of bile acids in the laying cycle of hens and their impact on lipid metabolism in chicken liver is not well understood. This study aimed to elucidate
Wen-Yuan Yang, Pei-En Chang, Yi-Ting Chen, Pei-Xin Liao, Yuan-Yu Lin   +4 more
doaj   +1 more source

Bile Acids and Their Value for Central Nervous System

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2022
Aim. A review to highlight the bile acids importance as steroid mediators of nervous system activity and show the nervous system involvement in cholesterol metabolism and bile acids production.Key points.
Yu. O. Shulpekova, P. E. Tkachenko, E. N. Shirokova, I. V. Damulin   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Application of a novel tool for diagnosing bile acid diarrhoea [PDF]

, 2013
Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose. We have tested the efficacy of a new method to identify BAD, based on the detection of differences in volatile organic compounds (VOC) in urine headspace of BAD vs.
Arasaradnam, Ramesh P., Ramesh Arasaradnam, James Covington, Ruth Harbord, Catherine Bailey, Chuka U. Nwokolo, Nicola O'Connell, James Cullis, Chuka Nwokolo, Nathalie Ouaret, Nwokolo, Chuka U., Ramesh P. Arasaradnam, Nicola O\u27Connell, Bardhan, Karna Dev, Eric Westenbrink, Karna D. Bardhan, Bailey, Catherine, Westenbrink, Eric W., James A. Covington, Ouaret, Nathalie, O'Connell, Nicola, Cullis, James, Nigel Williams, Eric W. Westenbrink, Karna Bardhan, Covington, James A., Williams, Nigel, Harbord, Ruth   +27 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Effect of Soluble Dietary Fiber from Highland Barley Bran on Bile Acid Metabolism in High Fat Diet Mice

Shipin gongye ke-ji
The processing of highland barley generates a significant quantity of bran, which is abundant in soluble dietary fiber (SDF), yet this by-product remains largely underutilized.
Furong LANG, Xuzhao WEI, Tongren WANG, Shulin WANG, Huicui LIU   +4 more
doaj   +1 more source

Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota

Frontiers in Medicine, 2022
The incidence and mortality of colorectal cancer (CRC) have been markedly increasing worldwide, causing a tremendous burden to the healthcare system. Therefore, it is crucial to investigate the risk factors and pathogenesis of CRC.
Xi Jiang, Zhongxiu Jiang, Qi Cheng, Wei Sun, Min Jiang, Yan Sun   +5 more
doaj   +1 more source

Weaving  Klotho into bile acid metabolism [PDF]

Journal of Clinical Investigation, 2005
Bile acids are natural detergents that assist in the absorption and digestion of fats in the intestine. In liver, the synthesis of bile acids from cholesterol is regulated by multiple signaling cascades that repress transcription of the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the classic bile acid synthesis ...
Antonio, Moschetta, Steven A, Kliewer
openaire   +2 more sources