Results 41 to 50 of about 3,456,901 (302)

Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet.

PLoS ONE, 2020
The incidence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, including in Asian countries. We reported that the hepatic expression of bile salt export pump (BSEP) was downregulated in patients with NASH, suggesting that BSEP is involved ...
Kazuya Okushin, Takeya Tsutsumi, Kazuhiko Ikeuchi, Akira Kado, Kenichiro Enooku, Hidetaka Fujinaga, Naoko Yamauchi, Tetsuo Ushiku, Kyoji Moriya, Hiroshi Yotsuyanagi, Kazuhiko Koike   +10 more
doaj   +1 more source

A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population [PDF]

, 2012
Background: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes.
Müllenbach, Roman, Marcin Krawczyk, Weber, Susanne N., Grünhage, Frank, Sarrazin, Christoph, Zimmer, Vincent, Frank Grünhage, Krawczyk, Marcin, Lammert, Frank, Christoph Sarrazin, Roman Müllenbach, Susanne N Weber, Vincent Zimmer, Frank Lammert   +13 more
core   +2 more sources

A Link between cholesterol levels and phenobarbital induction of cytochromes P450 [PDF]

, 2002
Squalestatin1 (SQ1), a potent inhibitor of squalene synthase produced a dose-dependent induction of cytochromes P450 CYP2H1 and CYP3A37 mRNAs in chicken hepatoma cells. The effect of SQ1 was completely reversed by 25-hydroxycholesterol.
Christoph Handschin, Handschin, C., Meyer, U. A., Urs A. Meyer, Kaufmann, M., Jean-Claude Ourlin, Michel Kaufmann, Ourlin, J. -C.   +7 more
core   +1 more source

Integrative analysis of the gut microbiota, bile acid pathways, and immune dysregulation in dyslipidemia models

iScience
Summary: Emerging evidence suggests a link between gut microbiota, bile acid metabolism, and immune dysregulation in dyslipidemia. Through a case-control study involving 140 participants and an animal experiment, we identified significantly elevated ...
Jiayue Xia, Yinqi Shao, Boxuan Li, Tianyu Wu, Zhi He, Zhiyuan Feng, Zhenzheng Zhang, Shiyu Yin, Yuanyuan Wang, Junhui Yu, Jiongnan Wang, Guiju Sun   +11 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Identification of molecular subtypes based on bile acid metabolism in cholangiocarcinoma

BMC Cancer
Background Cholangiocarcinoma is a highly heterogeneous tumor with bile acid metabolism involving in its development. The aim of this study was to characterize bile acid metabolism and identify specific subtypes to better stratify cholangiocarcinoma ...
Mingxia Deng, Jing Liu, Li Zhang, Yan Lou, Yunqing Qiu   +4 more
doaj   +1 more source

Effects of Different Monomeric Bile Acids in the Diet on the Growth and Lipid Metabolism of Juvenile Pacific White Shrimp

Animals
Bile acids are important for lipid digestion and metabolic regulation, but the roles of individual bile acids in crustaceans remain unclear. This study evaluated the effects of six dietary monomeric bile acids on growth and lipid metabolism in juvenile ...
Ziling Song, Yang Liu, Huan Liu, Zhengwei Ye, Lindong Xiao, Qiang Ma, Yuliang Wei, Mengqing Liang, Houguo Xu   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Gut microbial regulation of bile acid metabolism and signaling [PDF]

, 2016
The collection of microbes in our gastrointestinal tract, the gut microbiota, is an environmental factor that has profound impact on host health and disease.
Sayin, Sama
core   +1 more source

HuangQi ChiFeng decoction maintains gut microbiota and bile acid homeostasis through FXR signaling to improve atherosclerosis

Heliyon, 2023
Huangqi Chifeng Decoction (HQCFT), a traditional Chinese medicine preparation, has long been used to treat cardiovascular and cerebrovascular diseases. However, the mechanism of the beneficial effect of HQCFT on atherosclerosis remains to be explored. In
Jiaqi Fu, Yuqin Liang, Yunhe Shi, Donghua Yu, Yu Wang, Pingping Chen, Shumin Liu, Fang Lu   +7 more
doaj   +1 more source