Results 1 to 10 of about 4,715,473 (300)

Exploitation of Bile Acid Transport Systems in Prodrug Design

Molecules, 2007
The enterohepatic circulation of bile acids is one of the most efficient recycling routes in the human body. It is a complex process involving numerous transport proteins, which serve to transport bile acids from the small intestine into portal ...
Elina Sievänen
doaj   +4 more sources

Altered Bile Acid Transport in Liver Disease [PDF]

Biomedicines
Background/Objectives: Bile acids, synthesized from cholesterol in the liver, are amphipathic molecules that play an integral role in lipid digestion and absorption, while also serving as systemic endocrine hormones.
Sarah Cayton, Lindsay C. Czuba
doaj   +2 more sources

Hepatic bile acid transport increases in the postprandial state: A functional 11C-CSar PET/CT study in healthy humans [PDF]

JHEP Reports, 2021
Background & Aims: It is not known how hepatic bile acids transport kinetics changes postprandially in the intact liver. We used positron emission tomography (PET)/computed tomography (CT) with the tracer [N-methyl-11C]cholylsarcosine (11C-CSar), a ...
Nikolaj W. Ørntoft, Lars C. Gormsen, Susanne Keiding, Ole L. Munk, Peter Ott, Michael Sørensen   +5 more
doaj   +2 more sources

Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport Flow in a Cellular Negative Feedback Loop

Advanced Science, 2022
Bile acid‐modified nanoparticles provide a convenient strategy to improve oral bioavailability of poorly permeable drugs by exploiting specific interactions with bile acid transporters.
Feiyang Deng, Kyoung Sub Kim, Jiyoung Moon, You Han Bae   +3 more
doaj   +2 more sources

Substrate specificity of the ileal and the hepatic Na+/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters

Journal of Lipid Research, 1999
The substrate specificity of the ileal and the hepatic Na+/bile acid cotransporters was determined using brush border membrane vesicles and CHO cell lines permanently expressing the Na+/bile acid cotransporters from rabbit ileum or rabbit liver.
Werner Kramer, Siegfried Stengelin, Karl-Heinz Baringhaus, Alfons Enhsen, Hubert Heuer, Wolfgang Becker, Daniel Corsiero, Frank Girbig, Rüdiger Noll, Claudia Weyland   +9 more
doaj   +3 more sources

Intestinal transport and metabolism of bile acids [PDF]

Journal of Lipid Research, 2015
In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G protein-coupled receptors to regulate a myriad of cellular
Paul A. Dawson, Saul J. Karpen
doaj   +3 more sources

Genetic Disorders of Bile Acid Transport. [PDF]

Clin Liver Dis (Hoboken), 2021
Henkel AS.
europepmc   +4 more sources

Lymphatic transport of bile acids in man

Journal of Lipid Research, 1982
The possibility of a lymphatic transport of bile acids in man was investigated. Four patients were studied 2-4 weeks after renal transplantation.
S Ewerth, I Björkhem, K Einarsson, L Ost   +3 more
doaj   +3 more sources

Effects of Different Monomeric Bile Acids in the Diet on the Growth and Lipid Metabolism of Juvenile Pacific White Shrimp [PDF]

Animals
Bile acids are important for lipid digestion and metabolic regulation, but the roles of individual bile acids in crustaceans remain unclear. This study evaluated the effects of six dietary monomeric bile acids on growth and lipid metabolism in juvenile ...
Ziling Song, Yang Liu, Huan Liu, Zhengwei Ye, Lindong Xiao, Qiang Ma, Yuliang Wei, Mengqing Liang, Houguo Xu   +8 more
doaj   +2 more sources

Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. [PDF]

Stem Cell Reports, 2021
Hayashi H, Osaka S, Sakabe K, Fukami A, Kishimoto E, Aihara E, Sabu Y, Mizutani A, Kusuhara H, Naritaka N, Zhang W, Huppert SS, Sakabe M, Nakamura T, Hu YC, Mayhew C, Setchell K, Takebe T, Asai A.   +18 more
europepmc   +2 more sources