Results 31 to 40 of about 4,715,473 (300)

Inhibition of ileal sodium-dependent bile acid transport by 2164U90.

Journal of Lipid Research, 1995
Inhibition of the ileal bile acid active transport system, previously shown to be mechanism underlying the hypocholesterolemic activity of 2164U90 in rodents, was further characterized in isolated intestinal preparations from three species.
C Root, C D Smith, D A Winegar, L E Brieaddy, M C Lewis   +4 more
doaj   +1 more source

The role of 11β-hydroxysteroid dehydrogenase type 1 in bile acid homeostasis [PDF]

, 2013
Bile acids (BAs) are important modulators of metabolic functions such as lipid, triglyceride and glucose homeostasis. Intrahepatic accumulation of BAs is known to cause liver injury in cholestatic conditions, where normal trans-hepatic BA flow is ...
Penno, Carlos Alberto
core   +1 more source

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Beuers, Ulrich, Lehmann, Frank, Terracciano, Luigi, Hruz, Petr, Zimmermann, Christian, Gutmann, Heike, Drewe, Juergen, Beglinger, Christoph   +7 more
core   +1 more source

Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects [PDF]

, 2008
A common cause for referral to gastroenterologists is chronic watery diarrhoea. Approximately 40% of these patients have idiopathic bile acid malabsorption (BAM) – a condition with unknown aetiology.
Bajor, Antal
core   +1 more source

Regulation of Bile Acid and Cholesterol Metabolism by PPARs

PPAR Research, 2009
Bile acids are amphipathic molecules synthesized from cholesterol in the liver. Bile acid synthesis is a major pathway for hepatic cholesterol catabolism.
Tiangang Li, John Y. L. Chiang
doaj   +1 more source

Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Cholestasis promotes endoplasmic reticulum (ER) stress in the liver, however, the effect of ER stress on hepatic bile acid metabolism is unknown.
Anne S. Henkel, Brian LeCuyer, Shantel Olivares, Richard M. Green   +3 more
doaj   +1 more source

Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease [PDF]

, 1992
Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary ...
Sven Fischer, Seifferth, Bernd, Paumgartner, Gustav, Holl, Joseph, Frieder Berr, Werner Richter, Joseph Holl, Bernd Seifferth, Jüngst, Dieter, Dieter Jongst, Berr, Frieder, Richter, Werner O., Fischer, Sven, Gustav Paumgartner   +13 more
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Effect of phospholipids and bile acids on cholesterol nucleation time and vesicular/micellar cholesterol in gallbladder bile of patients with cholesterol stones [PDF]

, 1993
Supersaturation and rapid nucleation of cholesterol in bile are of key importance in the pathogenesis of cholesterol gallstones. While the effects of bile acids and phospholipids on cholesterol saturation of bile have been extensively studied, their ...
Paumgartner, Gustav, Lange, V., Jüngst, Dieter, Huber, P., Lang, Thomas   +4 more
core   +1 more source

Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. [PDF]

, 2010
TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to
Bergquist Annika, Melum, E., Andreas Teufel, Franke Andre, Ellinghaus Eva, Michael P. Manns, Benedicte A Lie, Stokkers, Pieter C. F., Stokkers, P.C.F., Weismueller, Tobias, Manns, M., Beuers Ulrich, Mathew, C., Keitel, V., Schramm Christoph, Bergquist, A., Weersma, R., Vatn, M., Christian Rust, Vatn, Morten H, Christoph Schramm, Hov, Johannes R, Stiehl Adolf, Ponsioen, C., Teufel, A., Rust Christian, Ponsioen, Cyriel Y, Henckaerts, L., Schrumpf, E., Erik Schrumpf, Balschun, T., Haeussinger, Dieter, Lie, B., Franke, Andre, Pieter C F Stokkers, Espen Melum, Annika Bergquist, Mathew, Christopher G, Melum, Espen, Spomer Lina, Boberg, K., Häussinger, D., Jon K. Laerdahl, null null, Daniel Gotthardt, Onnie Clive M., Franke, A., Beuers, U., Eva Ellinghaus, Wijmenga, Cisca, IBSEN Study Group, Laerdahl, J.K., Vatn, Morten H., Cisca Wijmenga, Gotthardt Daniel, Weersma, Rinse K., Hov Johannes R., Stokkers Pieter C. F., Beuers, Ulrich, Keitel Verena, Boberg Kirsten M., ElSharawy, Abdou, Mathew, Christopher G.; id_orcid, Vatn Morten H., Johannes R. Hov, Lie, Benedicte A., Häussinger, Dieter, Hov, J.R., Runz Heiko, Schrumpf Erik, Onnie, C.M., Liesbet Henckaerts, Vermeire, S., Weismüller, T., Teufel Andreas, Bergquist, Annika, Dieter Häussinger, Mathew Christopher G., Karlsen, T.H., Karlsen Tom H., Lie, B.A., Morten H Vatn, Keitel, Verena, Spomer, Lina, Onnie, C., Mathew, Christopher G., Stokkers, Pieter C F, Morten H. Vatn, Manns, Michael P, Weersma, R.K., ElSharawy Abdou, Jon K Laerdahl, Vermeire, Severine, Schreiber Stefan, Christopher G Mathew, Melum Espen, Tobias Weismüller, Henckaerts Liesbet, Onnie, Clive M., Tom H Karlsen, Ponsioen, C.Y., Ellinghaus, Eva, Manke Thomas, Onnie, Clive M, Runz, H., Schreiber, Stefan, Cyriel Y Ponsioen, Kirsten M. Boberg, Laerdahl, Jon K, Stokkers, P., Wijmenga, C., Wijmenga Cisca, Schreiber, S., Lina Spomer, Abdou ElSharawy, Lie, Benedicte A, Weersma, Rinse K, Stiehl, A., Stefan Schreiber, Severine Vermeire, Kirsten M Boberg, Adolf Stiehl, Weersma, Rinse K.; id_orcid, Schrumpf, Erik, Boberg, K.M., Stiehl, Adolf, Heiko Runz, Weismüller Tobias, Schramm, C., Sterneck, Martina, Gotthardt, D., Rinse K. Weersma, Ellinghaus, E., Boberg, Kirsten M., Verena Keitel, Spomer, L., Wijmenga, Cisca; id_orcid, Manke, Thomas, Elsharawy, A., Cyriel Y. Ponsioen, Schramm, Christoph, Vermeire Severine, Tobias Balschun, Karlsen, Tom H, Laerdahl, Jon K., Rust, C., Karlsen, T., Runz, Heiko, Manns Michael P., Laerdahl, J., Clive M Onnie, Teufel, Andreas, Martina Sterneck, Lie Benedicte A., Sterneck Martina, Häussinger Dieter, Christopher G. Mathew, Laerdahl Jon K., Weersma Rinse K., Mathew, C.G., Weismüller, Tobias, Henckaerts, Liesbet, Ponsioen, Cyriel Y., Boberg, Kirsten M, Benedicte A. Lie, Andre Franke, Sterneck, M., Ulrich Beuers, Thomas Manke, Vatn, M.H., Johannes R Hov, Ponsioen Cyriel Y., Manke, T., Karlsen, Tom H., Rinse K Weersma, Balschun Tobias, Pieter C. F. Stokkers, Balschun, Tobias, Hov, Johannes R., Hov, J., Tom H. Karlsen, Manns, Michael P., Manns, M.P., Michael P Manns, Gotthardt, Daniel, Rust, Christian, Clive M. Onnie   +186 more
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Functional analysis of four bile salt hydrolase and penicillin acylase family members in Lactobacillus plantarum WCFS1 [PDF]

, 2008
Bile salts play an important role in the digestion of lipids in vertebrates and are synthesized and conjugated to either glycine or taurine in the liver.
Lambert, J.M., Vos, W.M., de, Kleerebezem, M., Bongers, R.S., de Vos, W.M.   +4 more
core   +1 more source