Journal of Lipid Research, 2000 We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits.
Guorong Xu +13 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Three carriers of the solute carrier family SLC10 have been functionally characterized so far. Na+/taurocholate cotransporting polypeptide NTCP is a hepatic bile acid transporter and the cellular entry receptor for the hepatitis B and D viruses.
Gary Grosser +4 more
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Bile acid and cholesterol metabolism in atherosclerotic cardiovascular disease and therapy
Cardiology Plus, 2020 Dysregulation of lipid metabolism is a major factor contributing to atherosclerotic cardiovascular disease (ACVD), which is the number one cause of death in western countries.
John Y. L. Chiang +3 more
doaj +1 more source
Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]
, 2004 Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Thiessen, K. +5 more
core +1 more source
Effects of 2164U90 on ileal bile acid absorption and serum cholesterol in rats and mice.
Journal of Lipid Research, 1995 2164U90, [(3R,5R)-trans-3-butyl-3-ethyl-2,3,4,5-tetrahydro-5-phenyl-1,4- benzothiazepine 1,1-dioxide], was found to be a potent inhibitor of the ileal bile acid active transport system.
M C Lewis, L E Brieaddy, C Root
doaj +1 more source
Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2016 Alterations in bile acid (BA) synthesis and transport have the potential to affect multiple metabolic pathways in the pathophysiology of obesity.The objective of the study was to investigate the effects of obesity on serum fluctuations of BAs and markers of BA synthesis.We measured BA fluctuations in 11 nonobese and 32 obese subjects and BA transporter
Haeusler, Rebecca A +8 more
openaire +2 more sources
New synthetic bile acid analogue agonists of FXR and TGR5 receptors: Analytical methodologies for the study of their physico-chemical properties, pharmacokinetic activity and metabolism. [PDF]
, 2013 This thesis reports an integrated analytical approach for the study of physicochemical and biological properties of new synthetic bile acid (BA) analogues agonists of FXR and TGR5 receptors.
Colliva, Carolina <1981>
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Reconstitution of Bile Acid Transport in a Heterologous Cell by Cotransfection of Transporters for Bile Acid Uptake and Efflux [PDF]
Journal of Biological Chemistry, 1997 The rat liver canalicular bile acid transporter/ecto-ATPase/cell CAM 105 (CBATP) is a 110-kDa transmembrane phosphoglycoprotein that is thought to have bile acid efflux, ecto-ATPase, and cell adhesion properties. Its extracellular amino-terminal domain is highly homologous to carcinoembryonic antigen (CEA), a glycophosphatidyl inositol-anchored ...
C J, Sippel +3 more
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A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Albert K. Groen +12 more
core +1 more source
Improved annotation of conjugated bile acid hydrolase superfamily members in Gram-positive bacteria. [PDF]
, 2008 Contains fulltext : 69805.pdf (Publisher’s version ) (Closed access)Most Gram-positive bacteria inhabiting the gastrointestinal tract are capable of hydrolysing bile salts.
Lambert, J.M. +5 more
core +2 more sources