Results 41 to 50 of about 4,715,473 (300)

Application of a novel tool for diagnosing bile acid diarrhoea [PDF]

, 2013
Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose. We have tested the efficacy of a new method to identify BAD, based on the detection of differences in volatile organic compounds (VOC) in urine headspace of BAD vs.
Arasaradnam, Ramesh P., Ramesh Arasaradnam, James Covington, Ruth Harbord, Catherine Bailey, Chuka U. Nwokolo, Nicola O'Connell, James Cullis, Chuka Nwokolo, Nathalie Ouaret, Nwokolo, Chuka U., Ramesh P. Arasaradnam, Nicola O\u27Connell, Bardhan, Karna Dev, Eric Westenbrink, Karna D. Bardhan, Bailey, Catherine, Westenbrink, Eric W., James A. Covington, Ouaret, Nathalie, O'Connell, Nicola, Cullis, James, Nigel Williams, Eric W. Westenbrink, Karna Bardhan, Covington, James A., Williams, Nigel, Harbord, Ruth   +27 more
core   +1 more source

Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia.

Journal of Lipid Research, 1989
Biliary secretion of bile acid glucuronides was studied in control rats and in rats with a congenital defect in hepatobiliary transport of organic anions (GY rats).
F Kuipers, A Radominska, P Zimniak, J M Little, R Havinga, R J Vonk, R Lester   +6 more
doaj   +1 more source

Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis in the Human Hepatoma Cell Line HepaRG

Foods, 2021
1,2-unsaturated pyrrolizidine alkaloids (PAs) belong to a group of secondary plant metabolites. Exposure to PA-contaminated feed and food may cause severe hepatotoxicity.
Julia Waizenegger, Josephin Glück, Marcus Henricsson, Claudia Luckert, Albert Braeuning, Stefanie Hessel-Pras   +5 more
doaj   +1 more source

Role of High total protein in gallbladder bile in the formation of cholesterol gallstones. [PDF]

, 1991
While it is generally accepted that cholesterol supersaturation of bile is of key importance in the rapid formation of cholesterol crystals, the role of total biliary protein and pH in the pathogenesis of cholesterol gallstones is less well understood ...
Ritter, Christoph von, Paumgartner, Gustav, Jüngst, Dieter, Lang, Thomas   +3 more
core   +1 more source

Arylsulfonylamino-Benzanilides as Inhibitors of the Apical Sodium-Dependent Bile Salt Transporter (SLC10A2)

Molecules, 2013
The apical sodium-dependent bile salt transporter (ASBT) plays a pivotal role in maintaining bile acid homeostasis. Inhibition of ASBT would reduce bile acid pool size and lower cholesterol levels.
Rong-Guang Shao, Shi-Ying Cai, Chang-Liang Xu, Ju-Xian Wang, Xiao-Guang Bai, Hong-Wei He, Hong-Tao Liu, Yu-Cheng Wang   +7 more
doaj   +1 more source

Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition [PDF]

, 2010
Membrane transporters expressed by the hepatocyte and enterocyte play critical roles in maintaining the enterohepatic circulation of bile acids, an effective recycling and conservation mechanism that largely restricts these potentially cytotoxic detergents to the intestinal and hepatobiliary compartments.
openaire   +2 more sources

Mutations in SRD5B1 (AKR1D1), the gene encoding Delta(4)-3-oxosteroid 5 beta-reductase, in hepatitis and liver failure in infancy [PDF]

, 2003
Background: A substantial group of patients with cholestatic liver disease in infancy excrete, as the major urinary bile acids, the glycine and taurine conjugates of 7alpha-hydroxy-3-oxo-4-cholenoic acid and 7alpha, 12alpha-dihydroxy-3- oxo-4-cholenoic ...
Duran, M., Scambler, PJ, Custard, E. J., Bouquet, J, Lemonde, H. A., Clayton, P. T., Duran, M, Overmars, H, Bouquet, J., Scambler, P.J., Lemonde, H., Clayton, P.T., Custard, EJ, Scambler, P. J., Clayton, PT, Lemonde, HA, Custard, E.J., Overmars, H.   +17 more
core   +2 more sources

Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors

Nature Communications, 2021
Mutations in ENT3, encoded by SLC29A3, result in anaemia and erythroid hypoplasia, suggesting roles in erythropoiesis. Here the authors show that ENT3 acts as a lysosomal bile acid transporter, and mutation compromises taurine conjugated bile acid ...
Avinash K. Persaud, Sreenath Nair, Md Fazlur Rahman, Radhika Raj, Brenna Weadick, Debasis Nayak, Craig McElroy, Muruganandan Shanmugam, Sue Knoblaugh, Xiaolin Cheng, Rajgopal Govindarajan   +10 more
doaj   +1 more source

The Role of Bile in the Regulation of Exocrine Pancreatic Secretion [PDF]

, 1992
As early as 1926 Mellanby (1) was able to show that introduction of bile into the duodenum of anesthetized cats produces a copious flow of pancreatic juice.
Riepl, Rudolf L., Lehnert, Peter
core   +1 more source

Association between cholesterol-phospholipid vesicles and cholesterol crystals in human gallbladder bile [PDF]

, 1989
Rapid aggregation of cholesterol-phospholipid vesicles in gallbladder bile seems to be the first event in the production of cholesterol crystals, a prerequisite for cholesterol gallstone formation.
Schriever, Carolin Erika, Jüngst, Dieter   +1 more
core   +1 more source