Cellular and Molecular Gastroenterology and Hepatology, 2018 The organic solute transporter α-β (OSTα-OSTβ) mainly facilitates transport of bile acids across the basolateral membrane of ileal enterocytes. Therefore, inhibition of OSTα-OSTβ might have similar beneficial metabolic effects as intestine-specific ...
Sandra M.W. van de Wiel +3 more
doaj +1 more source
Does ursodeoxycholic acid change the proliferation of the colorectal mucosa? A randomized, placebo-controlled study [PDF]
, 2003 Background: In animal models ursodeoxycholic acid (UDCA) showed a chemoprotective effect against colon cancer. To explain this, a reduced proliferation of the colorectal mucosal proliferation was suggested.
Burkhard Göke +13 more
core +1 more source
Physiological characteristics of allo-cholic acid1
Journal of Lipid Research, 2003 The physiological characterstics of allo-cholic acid (A91), a typically fetal bile acid that reappears during liver regeneration and carcinogenesis were investigated.
Maria E. Mendoza +7 more
doaj +1 more source
Mechanism of Hydrophobic Bile Acid-Induced Hepatocyte Injury and Drug Discovery
Frontiers in Pharmacology, 2020 Cholestatic liver disease is caused by the obstruction of bile synthesis, transport, and excretion in or outside the liver by a variety of reasons.
Shizhang Wei +3 more
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Bile Acid Uptake Transporters as Targets for Therapy [PDF]
Digestive Diseases, 2017 <b><i>Background:</i></b> Bile acids are potent signaling molecules that regulate glucose, lipid and energy homeostasis predominantly via the bile acid receptors farnesoid X receptor (FXR) and transmembrane G protein-coupled receptor 5 (TGR5).
Slijepcevic, Davor +1 more
openaire +3 more sources
A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population [PDF]
, 2012 Background: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes.
Müllenbach, Roman +13 more
core +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Intestinal Absorption of Bile Salts
Canadian Journal of Gastroenterology, 1990 Bile acids are secreted from the liver into the duodenum where they aid in the digestion and absorption of dietary lipids. Absorption of bile acids occurs through both ionic and nonionic diffusion in the jejunum and colon and through an active sodium ion-
Karen Madsen
doaj +1 more source
Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids
Acta Pharmaceutica Sinica B, 2015 The classical functions of bile acids include acting as detergents to facilitate the digestion and absorption of nutrients in the gut. In addition, bile acids also act as signaling molecules to regulate glucose homeostasis, lipid metabolism and energy ...
Courtney B. Ferrebee, Paul A. Dawson
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