Results 121 to 130 of about 5,534,791 (400)

In vitro modeling of bile acid processing by the human fecal microbiota [PDF]

, 2018
Bile acids, the products of concerted host and gut bacterial metabolism, have important signaling functions within the mammalian metabolic system and a key role in digestion.
Elizabeth Want, Glynn Martin, James E. Sidaway, Jonathan R. Swann, Julian R. Marchesi, Julian R. Marchesi, Julian R. Marchesi, Sofia Kolida   +7 more
core   +4 more sources

Human gut bacteria produce ΤΗ17-modulating bile acid metabolites

Nature, 2022
Donggi Paik, Lina Yao, Yancong Zhang, Sena Bae, G. D’Agostino, Minghao Zhang, Eunha Kim, E. Franzosa, J. Ávila-Pacheco, J. Bisanz, Christopher K. Rakowski, H. Vlamakis, Ramnik J. Xavier, P. Turnbaugh, Randy S Longman, Michael R Krout, C. Clish, F. Rastinejad, C. Huttenhower, Jun R. Huh, A. Devlin   +20 more
semanticscholar   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

Advanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu   +16 more
wiley   +1 more source

Bile Acid Changes Associated With Liver Fibrosis and Steatosis in the Mexican‐American Population of South Texas

Hepatology Communications, 2020
Biomarkers to predict risk of liver fibrosis in subjects with nonalcoholic fatty liver disease, a common risk factor for hepatocellular carcinoma, would allow for early preventive interventions.
Suet Ying Kwan, Jingjing Jiao, Jonathan Qi, Ying Wang, Peng Wei, Joseph B. McCormick, Susan P. Fisher‐Hoch, Laura Beretta   +7 more
doaj   +1 more source

Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure

Advanced Science, EarlyView.
In mice challenged with lipopolysaccharide/D‐galactosamine (L/G), Mas signaling increased SHP2 in hepatic Col4a1+ endothelial cells, inhibiting farnesoid X receptor (FXR), potentially due to enterogenic deoxycholic acid. This inhibition activates sphingosine‐1‐phosphate‐induced Raf/MEK/ERK signaling in Cldn1+CD177+ neutrophils, causing neutrophil ...
Bo Yang, Shuai Chen, Xiaoqi Xia, Ziwen Tao, Chun Liu, Shanshan Li, Shuo Zhang, Jiali Huang, Lu Xia, Wenqiang Quan, Changqing Yang, Jing Li   +11 more
wiley   +1 more source

Hepatic bile acid uptake: effect of conjugation, hydroxyl and keto groups, and albumin binding

Journal of Lipid Research, 1982
Hepatic extraction of trihydroxy (free, glyco- and tauro-conjugated) dihydroxy, and monohydroxy bile acids has been evaluated in single pass liver perfusion experiments in rats.
R Aldini, A Roda, A M Labate, G Cappelleri, E Roda, L Barbara   +5 more
doaj  

Purification of total flavonoids from Aurea Helianthus flowers and In Vitro Hypolipidemic Effect [PDF]

arXiv, 2019
The effects of purification methods and its hypolipidemic function on the total flavonoids of Aurea Helianthus flower were investigated. Liquid-liquid extraction of ethanol extract from Aurea Helianthus flower was carried out by using different polar solvents. The extract with the highest total flavonoid content was selected, and the optimal conditions
arxiv  

Bile Acid Signaling in Liver Metabolism and Diseases [PDF]

, 2012
Obesity, diabetes, and metabolic syndromes are increasingly recognized as health concerns worldwide. Overnutrition and insulin resistance are the major causes of diabetic hyperglycemia and hyperlipidemia in humans.
Chiang, John Y. L., Li, Tiangang
core   +3 more sources

Bile acid oxidation by Eggerthella lenta strains C592 and DSM 2243T

Gut microbes, 2018
Strains of Eggerthella lenta are capable of oxidation-reduction reactions capable of oxidizing and epimerizing bile acid hydroxyl groups. Several genes encoding these enzymes, known as hydroxysteroid dehydrogenases (HSDH) have yet to be identified. It is
Spencer C. Harris, S. Devendran, Celia Méndez-García, Sean M. Mythen, C. Wright, C. Fields, Alvaro G. Hernandez, I. Cann, P. Hylemon, Jason M. Ridlon   +9 more
semanticscholar   +1 more source

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Advanced Science, EarlyView.
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du   +13 more
wiley   +1 more source