Results 251 to 260 of about 391,701 (312)

Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant

Clinical Pharmacology &Therapeutics, EarlyView.
Fezolinetant is a first‐in‐class, selective, non‐hormonal, neurokinin 3 receptor antagonist that is approved for the treatment of moderate to severe vasomotor symptoms due to menopause. In a phase 2b clinical study (n = 352), nine study participants experienced elevations in serum transaminases exceeding three times the upper limit of normal.
Jace C. Nielsen, Jeffrey L. Woodhead, Brett A. Howell, Lisl K. M. Shoda, Dolly A. Parasrampuria, Jiayin Huang, Megumi Iwai, Faith D. Ottery, Xuegong Wang, Marci English, Kentaro Miyazaki, Paul B. Watkins   +11 more
wiley   +1 more source

The U-shaped association between normal-range serum bile acid levels and prognosis of Coronary Heart Disease. [PDF]

Front Endocrinol (Lausanne)
Xu Y, Ding N, Hua R, Wu Y, Li T, Yuan Z.
europepmc   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Colonic Adaptation Postileal Resection: Bile Acid Absorption in an Ileal Resection Mouse Model. [PDF]

Gastroenterol Res Pract
Goto Y, Masumoto K, Sasaki T, Ono K, Ohno H, Araki M, Matsuzaka T, Shimano H.   +7 more
europepmc   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Disruption of the gut bile acid-microbiota axis precedes severe bronchopulmonary dysplasia in preterm infants. [PDF]

Front Microbiol
Yu H, Guo Y, Li J, Fu R, Zhang Y, Guo W.
europepmc   +1 more source

Effects of butter and corn oil on urinary taurine and fecal bile acid excretion in healthy young women /

, 1980
Shirley Gilliland Kindrick
openalex   +1 more source

Supplementary Table 2 from The Microbial Bile Acid Metabolite 3-Oxo-LCA Inhibits Colorectal Cancer Progression [PDF]

Fei Sun, Ke Wang, Xingchen Dong, Henry Secaira-Morocho, Alisa Hui, Chunmiao Cai, Jonathan J. Sze, Brian Low, Shirsa Udgata, Cheri A. Pasch, Tao Huan, Dustin A. Deming, Qiyun Zhu, Jiaoyang Jiang, Ting Fu   +14 more
openalex   +1 more source

The Prevalence and Burden of Avoidant/Restrictive Food Intake Disorder (ARFID) Symptoms in the Adult General Population of the UK and USA

International Journal of Eating Disorders, EarlyView.
ABSTRACT Introduction Avoidant/Restrictive Food Intake Disorder (ARFID) is a feeding and eating disorder characterized by avoidant/restrictive eating behaviors that lead to medical and/or functional impairments. While ARFID is increasingly recognized within pediatric populations and specialist clinics, data on its prevalence and burden within the adult
Grace Brownlow, Rosie Flack, Helen Burton‐Murray, Olafur Palsson, Imran Aziz   +4 more
wiley   +1 more source

Clock gene dysregulation in epilepsy: A systematic review

Epilepsia Open, EarlyView.
Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos, Arjune Sen, Francesca Panin, Krithika Sundararaman   +3 more
wiley   +1 more source