Results 111 to 120 of about 238,773 (337)

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

The ulcerogenic effect of bile and bile acid in rats during immobilization stress [PDF]

The effect of different concentrations of oxen bile and individual bile acids or their sodium salts on the gastric mucosa of rats was investigated in combination with immobilization stress.
Weisener, J.
core   +1 more source

The Role of Bile in the Regulation of Exocrine Pancreatic Secretion [PDF]

, 1992
As early as 1926 Mellanby (1) was able to show that introduction of bile into the duodenum of anesthetized cats produces a copious flow of pancreatic juice.
Adamczyk W, Andrén-Sandberg A, Aronchick CA, Björnsson OG, Björnsson OG, Brand SJ, Burhol PG, Davies HA, Dragstedt LR, Erlinger S, Eyre-Brook IA, Fausa O, Fiedler F, Forell MM, Forell MM, Forell MM, Forell MM, Forell MM, Frühauf S, Fölsch UR, Geratz JD, Gomez G, Green GM, Gries E, Grundy SM, Hanssen LE, Hartmann W, Hellmann G, Holtermuller KH, Holtermuller KH, Hotz J, Ivy AC, Kataoka K, Konturek SJ, Koop I, Koop I, Koop I, Koop I, Koop I, Kurosawa H, Kuroyanagi Y, Lagerlöf HO, Lehnert P, Lueth HC, Malagelada J-R, Malagelada J-R, Malagelada J-R, Mellanby J, Meyer JH, Miyasaka K, Miyasaka K, Miyasaka K, Miyasaka K, Nakamura R, Nakamura R, Namba M, Nustede R, Ohta H, Osnes M, Osnes M, Osnes M, Osnes M, Otte M, Peter Lehnert, Riepl RL, Riepl RL, Riepl RL, Riepl RL, Rudolf L. Riepl, Schaffalitzky de Muckadell OB, Shiratori K, Smallwood RA, Staub VL, Thomas JE, van Levan H, Wormsley KG   +75 more
core   +1 more source

SYNTHETIC INVESTIGATIONS ON THE DEGRADATION PRODUCTS OF BILE-ACIDS, SEX HORMONES ETC. PART I.  A SYNTHESIS OF 7-METHYL-0 :3 :3- BICYCLOOCTANE- I -ONE . [PDF]

, 1940
D. K. BANERJEE
openalex   +1 more source

Bile Acid Diarrhea

The Korean Journal of Gastroenterology
Diarrhea is a very common gastrointestinal symptom, and the presence of higher concentrations of bile acid in the colon leads to bile acid diarrhea (BAD). In BAD patients, a portion of bile from the small intestine that is normally controlled by enterohepatic circulation is present at a high concentration in the lumen of the large intestine, resulting ...
Hee Jin Kim, Hyun Jin Kim
openaire   +3 more sources

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification [PDF]

Toxicological Sciences, 2009
Sulfotransferase-2A1 catalyzes the formation of bile acid-sulfates (BA-sulfates). Sulfation of BAs increases their solubility, decreases their intestinal absorption, and enhances their fecal and urinary excretion. BA-sulfates are also less toxic than their unsulfated counterparts.
openaire   +3 more sources

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patients

Frontiers in Neuroscience, 2015
Bile acids may be involved in the regulation of food intake and energy metabolism. The aim of the study was to investigate the association of plasma bile acids with body mass index (BMI) and the possible involvement of circulating bile acids in the ...
Philip ePrinz, Tobias eHofmann, Anne eAhnis, Ulf eElbelt, Miriam eGoebel-Stengel, Burghard eKlapp, Matthias eRose, Andreas eStengel   +7 more
doaj   +1 more source

Metabolism of Bile Acids in Liver Slices and Homogenates [PDF]

, 1954
S. Bergström, Urs Gloor, Jessica Rumpf, Paavo Pääkkönen, Oiva Järvelä   +4 more
openalex   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source