Results 111 to 120 of about 234,802 (359)

Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng, Xin Yang, Jiani Sun, Ximing Ran, Dan Zhou, Mingming Ye, Li Wen, Ruirui Wang, Miaoxin Chen   +8 more
wiley   +1 more source

Regulation of bile acid synthesis in the rat: relationship between hepatic cholesterol 7 alpha-hydroxylase activity and portal bile acids.

Journal of Lipid Research, 1995
Bile acid biosynthesis has been believed to be regulated by negative feedback control; however, recent experiments have cast considerable doubts on the concept. The aim of the study was to examine the consensus of the negative feedback regulation of bile
K Fukushima, H Ichimiya, H Higashijima, H Yamashita, S Kuroki, K Chijiiwa, M Tanaka   +6 more
doaj  

An approximate cooperativity analysis by DSC of phase transitions of DPPC-DOCNa dispersions [PDF]

arXiv, 2001
The effect of solute, sodium deoxycholate bile salt (DOCNa), on the cooperativity of ordered-fluid, fosfolipid phase transition has been investigated by determining of the transition widths in multibilayer dispersions of the dipalmitoylphosphatidylcholine (DPPC)-DOCNa mixtures. The DT1/2 values were determined by differential scanning calorimetry.
arxiv  

Chemistry and biology of bile acids [PDF]

, 2004
This review makes an attempt to combine the insights gained into the biochemistry and physiology of bile acids with the elegant supramolecular systems designed from them.
Maitra, Uday, Mukhopadhyay, Samrat
core  

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

Advanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu, Xin Dong, Hao Zhou, Ze‐Yan Li, Bo Wang, Ya‐Ping Song, Zhi‐Bing Liu, Xue Lu, Yi‐Hao Zhang, Yichao Huang, Hua Wang, De‐Xiang Xu   +11 more
wiley   +1 more source

MRGPRX4 is a bile acid receptor for human cholestatic itch. [PDF]

, 2019
Patients with liver diseases often suffer from chronic itch, yet the pruritogen(s) and receptor(s) remain largely elusive. Here, we identify bile acids as natural ligands for MRGPRX4.
He, Renxi, Johnson, Omar, Lei, Xiaoguang, Li, Yulong, Liu, Simin, Luo, Wenqin, Peng, Luxin, Shi, Yaocheng, Sun, Jianjun, Wang, Xiaoqun, Wu, Qinxue, Wu, Zhaofa, Xu, Haifeng, Yang, Yong, Yu, Huasheng, Zeng, Zheng, Zhao, Tianjun, Zhuang, Zihao, Zou, Peng   +18 more
core   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Effect of bile acid deconjugation on the fecal excretion of steroids

Journal of Lipid Research, 1970
The effect of microbiological deconjugation of bile acids on total bile acid and neutral sterol fecal excretion by adult male rats has been studied. A screening method utilizing mice allowed selection of a Clostridium perfringens type A strain, which ...
Thomas F. Kellogg, P. Leonard Knight, Bernard S. Wostmann   +2 more
doaj  

Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

Acta Pharmaceutica Sinica B, 2015
The classical functions of bile acids include acting as detergents to facilitate the digestion and absorption of nutrients in the gut. In addition, bile acids also act as signaling molecules to regulate glucose homeostasis, lipid metabolism and energy ...
Courtney B. Ferrebee, Paul A. Dawson
doaj   +1 more source

Bile acids destabilise HIF-1a and promote anti-tumour phenotypes in cancer cell models. [PDF]

, 2016
BACKGROUND: The role of the microbiome has become synonymous with human health and disease. Bile acids, as essential components of the microbiome, have gained sustained credibility as potential modulators of cancer progression in several disease models ...
C Bernstein, C Legendre, CY Shi, F. J. Reen, F. O’Gara, GJ Jenkins, GL Semenza, GS Falchook, H Ajouz, H Kazumori, H Zeng, H Zhong, J. P. Phelan, JA Diaz-Gonzalez, JM Brown, JS Isaacs, JS Isaacs, JS Pyo, K Brown, K Lee, KW Lau, L Verberne, LG Rodriguez, M Baptissart, M Begley, ML Jones, N Rohwer, N Victor, N. Dunphy, P Louis, P Lu, R Hiramatsu, R. O’Connor, RA Bowe, S Hoelder, S Roman, SE Power, SS Hong, T Han, Y Hu, Y Lu, Y Yasuda, Y Zhu, YH Choi   +43 more
core   +1 more source