Results 141 to 150 of about 234,802 (359)
Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification [PDF]
Toxicological Sciences, 2009 Sulfotransferase-2A1 catalyzes the formation of bile acid-sulfates (BA-sulfates). Sulfation of BAs increases their solubility, decreases their intestinal absorption, and enhances their fecal and urinary excretion. BA-sulfates are also less toxic than their unsulfated counterparts.
openaire +3 more sources
Advanced Science, EarlyView.TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang +8 more
wiley +1 more source
A Hollow Shell‐Lattice Soft Robot in Flexible Pipelines with Flowing Fluids
Advanced Science, EarlyView.This study proposes a novel shell‐lattice robot with hollow bodies, capable of crawling through pipes with flowing fluids of high velocities and viscosities and mixed with impurities. The robot also features capabilities of crawling with high payloads, in curved pipes, and unthethered crawling. These unique properties make this robot high promising for
Di Guo, Yiqiang Wang, Zhan Kang
wiley +1 more source
Modeling of the formation of short-chain acids in propane flames [PDF]
arXiv, 2009 In order to better understand their potential formation in combustion systems, a detailed kinetic mechanism for the formation of short-chain monocarboxylic acids, formic (HCOOH), acetic (CH3COOH), propionic (C2H5COOH) and propenic (C2H3COOH)) acids, has been developed. Simulations of lean (equivalence ratios from 0.9 to 0.48) laminar premixed flames of
arxiv
Biosynthesis of bile acids [PDF]
, 1968 Cholesterol, along with a number of its derivatives and very small quantities of its precursors, is the only sterol which can be identified in extracts of mammalian tissue.
Percy-Robb, Iain Walter
core
On the Conversion of 3alpha,7alpha,12alpha-Trihydroxycoprostanic Acid to Cholic Acid in Rat Liver Homogenates. Bile Acids and Steroids. 46. [PDF]
, 1957 S. Bergström +6 more
openalex +1 more source
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) extracellular vesicle (EV) surface protein assay operates via a two‐step workflow – Step 1: Click chemistry‐mediated enrichment of PDAC EVs by EV Click Beads, in the presence of one of the three trans‐cyclooctene‐grafted PDAC EV‐specific antibodies; Step 2: Quantification of the enriched PDAC EVs by reverse ...
Chen Zhao +27 more
wiley +1 more source
Вплив блокади опіоїдних рецепторів на співвідношення холатів у жовчі щурів із експериментальним алкогольним гепатитом [PDF]
, 2012 Показано, что при воздействии этанола уменьшается синтез желчных кислот, в частности угнетается гидроксилирование желчных кислот. Применение налокс она в условиях экспериментального алкогольного гепатита у крыс вызывает угнетение гидроксилирования и ...
Решетнік, Є.М.
core
Advanced Science, EarlyView.Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian +16 more
wiley +1 more source
Histological insight into the hepatic tissue of the Nile monitor (Varanus niloticus) [PDF]
arXiv, 2018 The liver of reptiles is considered an important study model for the interaction between environment and hepatic tissue. Little is known about the histology of the liver of reptiles. The aim of the current study was to elucidate the histological architecture of the liver of the Nile monitor (Varanus niloticus).
arxiv