Results 151 to 160 of about 234,802 (359)

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

open access: yesAdvanced Science, EarlyView.
Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang   +10 more
wiley   +1 more source

Inhibition of canalicular and sinusoidal taurocholate efflux by cholestatic drugs in human hepatoma HepaRG cells

open access: yesBiopharmaceutics &Drug Disposition, Volume 43, Issue 6, Page 265-271, December 2022., 2022
Effects of cholestatic drugs towards hepatic canalicular and sinusoidal secretion of bile acids were investigated using a biphasic functional assay in human hepatoma HepaRG cells. After an initial loading phase with taurocholate, cells were re‐incubated in taurocholate‐free medium (efflux phase), with or without calcium (for modulating the opening of ...
Marc Le Vée   +5 more
wiley   +1 more source

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

open access: yesJournal of Lipid Research, 2014
During the last 80 years there have been extraordinary advances in our knowledge of the chemistry and biology of bile acids. We present here a brief history of the major achievements as we perceive them.
Alan F. Hofmann, Lee R. Hagey
doaj  

LC/ESI-MS analysis of underivatized amino acids and mass spectrum [PDF]

open access: yesarXiv, 2016
We report the method of LC/ESI-MS analysis of underivatized amino acids with corresponding mass spectrum and fragmentation patterns. Diagnostic product ions determined by mass spectrometry can support the qualitative identification and quantitative estimation of individual amino acids. Therefore, the optimization of chromatographic separation using the
arxiv  

The Role of Bifidobacterium SPP. on Cholestrol Assimilation in the in Vitro and in Vivo Studies [PDF]

open access: yes, 2001
The purpose of this study was to investigate the cholesterol removal by some bifidobacterium spp. at in vitro and in vivo conditions with the emphasis of their bile salt deconjugation ability.
Sabet, Maryam Rezaei
core  

Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease

open access: yesAdvanced Science, EarlyView.
Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and extracellular matrix stiffening. An in vitro NAFLD model is developed using engineered hydrogels (G′ ≈ 1–6 kPa) and iPSC‐derived hepatic organoids. It is demonstrated that higher stiffness can increase lipid droplet accumulation, fibrosis, and metabolic dysregulation ...
Yueming Liu   +11 more
wiley   +1 more source

Proton magnetic resonance assay of total and taurine-conjugated bile acids in bile

open access: yesJournal of Lipid Research, 1999
Biliary bile acids, coexisting with phospholipid and cholesterol, are partly conjugated with taurine. In the present report we show that total and taurine-conjugated bile acids in bile can be simultaneously and quantitatively measured by high-resolution ...
Hiroki Ishikawa   +8 more
doaj  

Correlations of Amino Acids with Secondary Structure Types: Connection with Amino Acid Structure [PDF]

open access: yesarXiv, 2005
The correlations of primary and secondary structures were analyzed using proteins with known structure from Protein Data Bank. The correlation values of amino acid type and the eight secondary structure types at distant position were calculated for distances between -25 and 25.
arxiv  

Downregulation of intestinal Farnesoid X Receptor in Erythropoietic protoporphyria [PDF]

open access: yes, 2017
Erythropoietic protoporphyria (EPP) is characterized by accumulation of protoporphyrin IX (PPIX) in the body. The liver is the major organ responsible for PPIX excretion through the biliary system. Because PPIX is highly hydrophobic, an excess amount of
Pradhan, Komal
core  

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