Results 291 to 300 of about 234,802 (359)

Inhibition of OATP1B1/3 Rather Than UGT1A1 May Be the Major Cause of the Bilirubin Elevation After Atazanavir Administration

Clinical Pharmacology &Therapeutics, EarlyView.
Atazanavir has been reported to increase total serum bilirubin level up to ninefold. It is widely believed that the observed total bilirubin elevation is primarily due to UGT1A1 inhibition. However, UGT enzymes are well‐known as a low‐affinity and high‐capacity system, and the observed drug–drug interaction mediated by UGTs is usually less than twofold.
Jin Dong, Pradeep Sharma, Rasha Emara, Derek Cheung, Weifeng Tang, Diansong Zhou, David W. Boulton, Mats Någård, Miki S. Park   +8 more
wiley   +1 more source

Gut microbiota and bile acids: Metabolic interactions and impacts on diabetic kidney disease. [PDF]

Curr Res Microb Sci
Liu P, Jin M, Hu P, Sun W, Tang Y, Wu J, Zhang D, Yang L, He H, Xu X.   +9 more
europepmc   +1 more source

SLCO1B1 Functional Variants, Bilirubin, Statin‐Induced Myotoxicity, and Recent Sub‐Saharan African Ancestry: A Precision Medicine Health Equity Study

Clinical Pharmacology &Therapeutics, EarlyView.
Statin pharmacogenetic implementation guidelines are derived from evidence of primarily Eurocentrically biased study populations. Functional SLCO1B1 variants that are rare in these study populations have not been equitably investigated and are thus missing from guidelines.
Tanushree Haldar, Mark Kvale, Jia Yang, Michael P. Douglas, Willow Coyote‐Maetas, Linda Kachuri, John S. Witte, Carlos Iribarren, Marisa W. Medina, Ronald M. Krauss, Sook Wah Yee, Akinyemi Oni‐Orisan   +11 more
wiley   +1 more source

Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus. [PDF]

Front Endocrinol (Lausanne)
Yang H, Zhang Y, Hong Y, Wei Y, Zhu Y, Huang L, Yang Y, Sun R, Li J.   +8 more
europepmc   +1 more source

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2)

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers predictive of BCRP function in humans.
Andrew M. Riselli, Sook Wah Yee, Jia Yang, Claire M. Brett, Kelsey Trumbach, Xujia Zhou, Renmeng Liu, Xiaomin Liang, Yurong Lai, Runlan Huo, Yongjun Xue, Hong Shen, Lei Zhang, Xinning Yang, Qi Liu, Shiew‐Mei Huang, Kathleen M. Giacomini   +16 more
wiley   +1 more source

Emerging role of bile acids in colorectal liver metastasis: From molecular mechanism to clinical significance (Review). [PDF]

Int J Oncol
Li Z, Deng L, Cheng M, Ye X, Yang N, Fan Z, Sun L.   +6 more
europepmc   +1 more source

Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation. [PDF]

J Transl Med
Zhang ZY, Guo XL, Liu JT, Gu YJ, Ji XW, Zhu S, Xie JY, Guo F.   +7 more
europepmc   +1 more source

Ruthenium‐Catalyzed Isomerization of Oxabicyclic Alkenes to 1,2‐Naphthalene Oxides: A DFT Study

European Journal of Organic Chemistry, Accepted Article.
The mechanism and regioselectivity of ruthenium‐catalysed isomerisation of C1‐substituted, unsymmetrical oxabenzonorbornadienes (OBDs) were investigated using density functional theory (DFT). This study elucidates a three‐step catalytic cycle: oxidative addition, η1‐ to η3‐allyl isomerisation, and reductive elimination.
William Tam, Austin Pounder, Noah King
wiley   +1 more source

Dietary bile acids supplementation decreases hepatic fat deposition with the involvement of altered gut microbiota and liver bile acids profile in broiler chickens. [PDF]

J Anim Sci Biotechnol
Wang M, Li K, Jiao H, Zhao J, Li H, Zhou Y, Cao A, Wang J, Wang X, Lin H.   +9 more
europepmc   +1 more source

A Comprehensive Review on Capillary Electrophoresis–Mass Spectrometry in Advancing Biomolecular Research

ELECTROPHORESIS, EarlyView.
ABSTRACT This review provides an in‐depth exploration of capillary electrophoresis–mass spectrometry (CE–MS) in biomolecular research from 2020 to 2024. CE–MS emerges as a versatile and powerful tool due to its numerous advantages, facilitating the analysis of various biomolecules, including proteins, peptides, oligonucleotides, and other metabolites ...
Laura Pont, María Vergara‐Barberán, Enrique Javier Carrasco‐Correa   +2 more
wiley   +1 more source