Results 81 to 90 of about 234,836 (306)

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Bioactivities, Mechanisms, Production, and Potential Application of Bile Acids in Preventing and Treating Infectious Diseases

Engineering
Infectious diseases are a global public health problem, with emerging and re-emerging infectious diseases on the rise worldwide. Therefore, their prevention and treatment are still major challenges.
Shuang Liu, Shuo Yang, Biljana Blazekovic, Lu Li, Jidan Zhang, Yi Wang   +5 more
doaj   +1 more source

Occurrence of sulfated 5α-cholanoates in rat bile1

Journal of Lipid Research, 1978
Bile acids in bile from male and female rats with cannulated bile ducts have been analyzed by repetitive scanning gas–liquid chromatography–mass spectrometry after initial fractionation of conjugate classes on diethylaminohydroxypropyl Sephadex LH-20 ...
H Eriksson, W Taylor, J Sjövall
doaj   +1 more source

Critical roles of bile acids in regulating intestinal mucosal immune responses

Therapeutic Advances in Gastroenterology, 2021
Bile acids are a class of cholesterol derivatives that have been known for a long time for their critical roles in facilitating the digestion and absorption of lipid from the daily diet.
Ruicong Sun, Chunjin Xu, Baisui Feng, Xiang Gao, Zhanju Liu   +4 more
doaj   +1 more source

Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake [PDF]

, 2016
Acute biliary pancreatitis, caused by bile reflux into the pancreas, is a serious condition characterised by premature activation of digestive enzymes within acinar cells, followed by necrosis and inflammation. Bile acids are known to induce pathological
Ferdek, Pawel E., Gerasimenko, Julia V., Gerasimenko, Oleg V., Jakubowska, Monika A., Petersen, Ole H.   +4 more
core   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Very long O-antigen chains enhance fitness during Salmonella-induced colitis by increasing bile resistance. [PDF]

, 2012
Intestinal inflammation changes the luminal habitat for microbes through mechanisms that have not been fully resolved. We noticed that the FepE regulator of very long O-antigen chain assembly in the enteric pathogen Salmonella enterica serotype ...
Bäumler, Andreas J, Crawford, Robert W, Keestra, A Marijke, Tolstikov, Vladimir, Tsolis, Renée M, Winter, Sebastian E, Xavier, Mariana N   +6 more
core  

Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model [PDF]

, 2008
The transgenomic metabolic effects of exposure to either Lactobacillus paracasei or Lactobacillus rhamnosus probiotics have been measured and mapped in humanized extended genome mice (germ-free mice colonized with human baby flora).
Allison C, Blum S, Cummings JH, Donaldson RM, Elaine Holmes, Fan TW, Francois‐Pierre J Martin, Fuller R, Ikram‐ul H, Ivan K S Yap, Jeremy K Nicholson, John C Lindon, Laurent B Fay, Macfarlane GT, Norbert Sprenger, Per Lek, Peter van Bladeren, Serge Rezzi, Sunil Kochhar, Torbjörn Lundstedt, Yulan Wang, Zeisel SH, Ziad Ramadan   +22 more
core   +2 more sources

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source