Results 201 to 210 of about 29,638 (318)

The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat

open access: yesExperimental Physiology, EarlyView.
Abstract The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason for discontinuation of these drugs; however, the underlying mechanisms are unknown.
Sofia Cussotto   +10 more
wiley   +1 more source

7β-Hydroxysteroid dehydratase Hsh3 eliminates the 7-hydroxy group of the bile salt ursodeoxycholate during degradation by <i>Sphingobium</i> sp. strain Chol11 and other <i>Sphingomonadaceae</i>. [PDF]

open access: yesAppl Environ Microbiol
Richtsmeier P   +10 more
europepmc   +1 more source

Bile acids and colonic motility in the rabbit and the human.

open access: yesGut, 1975
W. Kirwan   +4 more
semanticscholar   +1 more source

Early Diagnosis of Acute Kidney Injury in Liver Transplant Patients by an Untargeted Metabolomic Approach

open access: yesAnalytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT Acute kidney injury is a common complication in patients undergoing orthotopic liver transplantation, being associated with increased mortality and prolonged hospitalization. This study aimed to develop a novel analytical strategy for the early diagnosis of acute kidney injury in liver transplant recipients by combining an untargeted ...
Larissa C. Motta   +13 more
wiley   +1 more source

Murine norovirus allosteric escape mutants mimic gut activation. [PDF]

open access: yesJ Virol
Sherman MB   +6 more
europepmc   +1 more source

Glycine N‐Acyltransferase Deficiency due to a Homozygous Nonsense Variant in the GLYAT: A Novel Inborn Error of Metabolism

open access: yesJIMD Reports, Volume 66, Issue 5, September 2025.
ABSTRACT The enzyme glycine N‐acyltransferase (GLYAT) plays a crucial role in detoxifying both xenobiotic and endogenous compounds that contain a carboxylic acid group, such as benzoic acid. Data on the impact of human GLYAT on the glycine conjugation pathway is limited and difficult to determine.
Mona Nourbakhsh   +13 more
wiley   +1 more source

Transforming Growth Factor‐Beta Signaling in Cancer: Therapeutic Implications, Challenges, and Pathways to Progress

open access: yesMedComm – Oncology, Volume 4, Issue 3, September 2025.
TGF‐β inhibition is emerging as a promising cancer therapy, yet translating laboratory success to bedside implementation has suffered significant setbacks. The associated challenges include adverse drug reactions, inadequate predictive models, and activation of alternative signaling pathways.
Faizah A. Alabi   +5 more
wiley   +1 more source

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