Bile acids accumulate norovirus-like particles and enhance binding to and entry into human enteric epithelial cells. [PDF]
Hahlin E +11 more
europepmc +1 more source
Maize Biofortification Approaches for Fighting Malnutrition in Sub‐Saharan Africa
ABSTRACT Maize is a staple food in sub‐Saharan Africa (SSA); however, commonly used maize varieties are deficient in essential nutrients, including lysine, tryptophan, vitamin A, and minerals such as iron (Fe) and zinc (Zn). As a result, millions of people in this region suffer from one or more nutrient deficiencies that commonly lead to malnutrition ...
Bitew Tilahun Engida +2 more
wiley +1 more source
Therapeutic modulation of the gut microbiota by traditional Chinese medicine in the management of cholestatic liver injury. [PDF]
Ding X, Wang J, Wang Y, Xu H, Liu Y.
europepmc +1 more source
ABSTRACT Background People with cystic fibrosis (CF) are at increased risk of fat‐soluble vitamin (A, D, E, and K) deficiencies secondary to exocrine pancreatic insufficiency (EPI). Estimation of vitamin K deficiency in routine clinical practice is challenging, and no uniform consensus exists due to lack of an accurate clinical test for the evaluation ...
Senthilkumar Sankararaman +7 more
wiley +1 more source
The interplay between bile acid metabolism and gut microbiome in biliary tract cancers. [PDF]
Ike I +7 more
europepmc +1 more source
Sex‐Related Differences in Physiologically‐Based Biopharmaceutics Modeling
Sex‐related differences in gastrointestinal tract physiology and their incorporation into three widely used PBPK platforms (PK‐Sim, GastroPlus, Simcyp) were evaluated. A ketoprofen PBPK model was developed and verified in males, then extrapolated to females using default and sex‐specific refined parameters, demonstrating that user‐defined adjustments ...
Marianela Chavarría‐Rojas +4 more
wiley +1 more source
Untargeted metabolomics reveals effects of calorie restriction on skeletal muscle in older female and male rats. [PDF]
Wang H, Hao J, Cartee GD.
europepmc +1 more source
Machine Learning Enables Rapid Prediction of Acid‐Reducing Agent Drug Interactions: A Streamlined Complement to PBPK Modeling. ABSTRACT pH‐dependent drug–drug interactions (DDIs) commonly occur when acid‐reducing agents (ARAs) are co‐administered with weakly basic drugs.
Yuanfang Qin +6 more
wiley +1 more source
Preliminary Functional Screening of Autochthonous <i>Saccharomyces cerevisiae</i> from Mexican Cocoa Bean Fermentation for Traits Associated with Probiotic Potential. [PDF]
López-Palestino A +8 more
europepmc +1 more source
Vibrio communities shape carbenicillinase diversity in European coasts. Sediments serve as reservoirs of antibiotic‐resistant Vibrio alginolyticus, which can move into the water column and accumulate in bivalves. This spreads β‐lactamase resistance and raises human exposure risks to antibiotic‐resistant pathogenic Vibrio, especially as higher seawater ...
Berenice Reggiardo +23 more
wiley +1 more source

