Results 251 to 260 of about 29,638 (318)

Evaluating Effects of Antibiotics Across Preclinical Models of the Human Gastrointestinal Microbiota

MicrobiologyOpen, Volume 14, Issue 4, August 2025.
We compared microbiota changes following antibiotic treatment in two preclinical models of the human GI microbiota, minibioreactor arrays (MBRAs) and human microbiota associated mice (HMAmice). MBRAs and HMAmice were colonized with feces from 12 or 3 healthy humans, respectively, before treatment with each of 12 or 6 antibiotics.
Thomas A. Auchtung, Armando I. Lerma, Keegan Schuchart, Jennifer M. Auchtung   +3 more
wiley   +1 more source

Phenotypic analysis of various <i>Clostridioides difficile</i> ribotypes reveals consistency among core processes. [PDF]

Appl Environ Microbiol
Beebe MA, Paredes-Sabja D, Kociolek LK, Rodríguez C, Sorg JA.   +4 more
europepmc   +1 more source

Evolving nutrition therapy in cystic fibrosis: Adapting to the CFTR modulator era

Nutrition in Clinical Practice, Volume 40, Issue 4, Page 816-828, August 2025.
Abstract Cystic fibrosis transmembrane regulator (CFTR)–directed therapies, such as modulators, have transformed the medical management of people with CF, resulting in better lung function, weight, and body mass index in recent years. With improved nutrition status in people on CFTR modulators, the emphasis on a high‐energy, high‐fat diet (the legacy ...
Kay Vavrina, Tara B. Griffin, Angel M. Jones, Terri Schindler, Trang N. Bui, Senthilkumar Sankararaman   +5 more
wiley   +1 more source

Bile acids affect intestinal barrier function through FXR and TGR5. [PDF]

Front Med (Lausanne)
Song G, Xie Y, Yi L, Cheng W, Jia H, Shi W, Liu Q, Fang L, Xue S, Liu D, Zhu J, Zhao S.   +11 more
europepmc   +1 more source

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, Volume 182, Issue 16, Page 3744-3766, August 2025.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Bile acids and gestational diabetes mellitus: exploring the link and implications - a review. [PDF]

Front Endocrinol (Lausanne)
Lu C, Li C, Lei X.
europepmc   +1 more source

Proteomic associations with fluctuation and long‐term changes in BMI: A 40‐year follow‐up study

Diabetes, Obesity and Metabolism, Volume 27, Issue 8, Page 4192-4202, August 2025.
Abstract Introduction While some studies have explored associations between weight change and blood proteins, most have been intervention‐based, offering limited insight into proteomic associations with long‐term weight gain. It remains unclear whether plasma proteins are related to BMI fluctuation over time.
Alvaro Obeso, Gabin Drouard, Teemu Palviainen, Xiaoling Wang, Miina Ollikainen, Karri Silventoinen, Jaakko Kaprio   +6 more
wiley   +1 more source

Identification of Soy-Derived Peptides With Micelle Disruption Activity of Secondary Bile Acids. [PDF]

Food Sci Nutr
Shimizu S, Hirano K, Saito T, Akiyama H, Shimizu K, Honda H.   +5 more
europepmc   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone, Jean‐Pierre Després, John P. A. Ioannidis, Ian J. Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H. Schindler, Maria Paula Macedo, Agostino Di Ciaula, Marcin Krawczyk, Andreas Geier, Gyorgy Baffy, Maria Felicia Faienza, Ilaria Farella, Nicola Santoro, Gema Frühbeck, Patricia Yárnoz‐Esquiroz, Javier Gómez‐Ambrosi, Emma Chávez‐Manzanera, Verónica Vázquez‐Velázquez, Jean‐Michel Oppert, Dimitrios N. Kiortsis, Paolo Sbraccia, Carmine Zoccali, Piero Portincasa, Fabrizio Montecucco   +28 more
wiley   +1 more source