Results 271 to 280 of about 26,722 (309)
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Digestive and Liver Disease, 2016
Dysregulation of systemic bile acid homeostasis can lead to cholestatic liver diseases and metabolic syndromes. As important anti-inflammatory and immunosuppressive drugs, synthetic glucocorticoids (GCs) are used to treat several cholestatic disorders, including biliary atresia (BA), because of their effects on the regulation of bile acid metabolism ...
Yongtao, Xiao +4 more
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Dysregulation of systemic bile acid homeostasis can lead to cholestatic liver diseases and metabolic syndromes. As important anti-inflammatory and immunosuppressive drugs, synthetic glucocorticoids (GCs) are used to treat several cholestatic disorders, including biliary atresia (BA), because of their effects on the regulation of bile acid metabolism ...
Yongtao, Xiao +4 more
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Journal of Cellular Physiology, 2018
AbstractObjectiveGlycochenodeoxycholate acid (GCDA) is a toxic component in bile salts. It plays an important role in the development and progression of liver cancer. In this study, we investigated the underlying mechanism of GCDA in hepatocarcinogenesis and chemotherapy resistance.Materials and MethodsCell proliferation was measured by 3‐(4,5 ...
Chengzhi, Wang +7 more
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AbstractObjectiveGlycochenodeoxycholate acid (GCDA) is a toxic component in bile salts. It plays an important role in the development and progression of liver cancer. In this study, we investigated the underlying mechanism of GCDA in hepatocarcinogenesis and chemotherapy resistance.Materials and MethodsCell proliferation was measured by 3‐(4,5 ...
Chengzhi, Wang +7 more
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Micellar Solubilization of Fatty Acids and Monoglycerides by Bile Salt Solutions
Nature, 1961BILE salts were recognized as detergents some years ago1, but few investigations have been done on their detergent properties under physiological conditions. Aqueous solutions of detergents are known to form molecular aggregates called micelles2. These form above a critical micellar concentration (CMC) and can solubilize water-insoluble materials ...
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Molecular interactions between selected sodium salts of bile acids and morphine hydrochloride
Colloids and Surfaces B: Biointerfaces, 2012The objective of this study was to understand the prolonged analgesic action of morphine hydrochloride observed in the presence of sodium 12-oxochenodeoxycholanate. Based on literature, this phenomenon may be due to the formation of aggregates in the cell between the molecules of bile acids and morphine.
Mihalj Poša +4 more
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The absorption of bile salt and fatty acid by hamster small intestine
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968Abstract 1. 1. Hamster intestinal rings were incubated at 37° in a micellar solution containing 2.4 μmoles of sodium taurodeoxycholate, 0.6 pnole of oleic acid, 0.3 μmole of monoolein, and trace amounts of sodium [carboxy-14C]taurodeoxycholate and [9,10-3H2]oleic acid in Krebs-Ringer phosphate buffer (pH 6.3).
S G, Gordon, F, Kern
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Jejunal cAMP-activated sodium secretion via deconjugated bile salts and fatty acids
Biochemical Medicine, 1981Abstract Jejunal cAMP-activated sodium secretion associated with in vivo intraluminal bile salts and free fatty acid accumulation in the small bowel was studied. Wistar rats (70–90 g) were treated with mecamylamine HCl (20 mg/kg twice daily, × 3 days); this ganglionic blocking agent allows bacterial overgrowth of the small bowel with colonic ...
M, Berant +3 more
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Pharmaceutical Research, 1992
The effects of four bile salts, one fusidate derivative, and one mixed micellar formulation of bile salt-fatty acid combination on the nasal mucosal protein and enzyme release have been investigated in rats using an in situ nasal perfusion technique.
Z, Shao, A K, Mitra
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The effects of four bile salts, one fusidate derivative, and one mixed micellar formulation of bile salt-fatty acid combination on the nasal mucosal protein and enzyme release have been investigated in rats using an in situ nasal perfusion technique.
Z, Shao, A K, Mitra
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Biotechnology Letters, 2012
The effect of the conjugated bile acid (BA) on the microbial internal pH (pHin) values in lactic acid bacteria with and without ability to hydrolyze bile salts (BSH[+] and BSH[-] strains, respectively) was evaluated. BSH(+) strains showed a gradual increase in the pHin following the addition of conjugated BA; this behavior was more pronounced with GDCA
Bustos, Ana Yanina +4 more
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The effect of the conjugated bile acid (BA) on the microbial internal pH (pHin) values in lactic acid bacteria with and without ability to hydrolyze bile salts (BSH[+] and BSH[-] strains, respectively) was evaluated. BSH(+) strains showed a gradual increase in the pHin following the addition of conjugated BA; this behavior was more pronounced with GDCA
Bustos, Ana Yanina +4 more
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Bile Salts, Bile Flow, and Iopanoic Acid Metabolism
Investigative Radiology, 1971Albert A. Moss +2 more
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Letter: In vitro binding of bile acids and bile salts
The American Journal of Clinical Nutrition, 1975D, Kritchevsky, J A, Story
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