Results 311 to 320 of about 57,138 (354)

Bile acid and bile salt disrupt gastric mucosal barrier in the dog by different mechanisms

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1982
The present study was undertaken to assess the mechanism by which protonated taurocholic acid disrupts the gastric mucosal barrier. By the criterion of lecithin solubilization, the critical micellar concentration of taurocholic acid (pH 1) was 4.5 mM, as opposed to 3.0 mM for sodium taurocholate (pH 7).
W C, Duane, D M, Wiegand, C E, Sievert
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Acid Dissociation Constants of Bilirubin and Related Carboxylic Acid Compounds in Bile Salt Solutions

Archives of Biochemistry and Biophysics, 2000
Bilirubin, the yellow-orange tetrapyrrole pigment of jaundice, is essentially insoluble in pure water, but is much more soluble in solutions of bile salts such as sodium taurocholate. The biophysical chemistry of bilirubin in bile salt solutions is affected by changes in the pH of the solution in the range 5-9, suggesting that interactions with bile ...
W E, Kurtin, J, Enz, C, Dunsmoor, N, Evans, D A, Lightner   +4 more
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Adsorption of bile acid by chitosan salts prepared with cinnamic acid and analogue compounds

Journal of Biomaterials Science, Polymer Edition, 2006
A chitosan (CS) powder treated with cinnamic acid and an analogue compound (CN) was prepared as CS-CN. Using it, bile acid adsorption by CS-CN and the release of CN were investigated in vitro. When CS-CN was soaked in a taurocholate solution, it released CN and simultaneously adsorbed the bile acid.
Yoshifumi, Murata, Kumiko, Nagaki, Kyouko, Kofuji, Fujiko, Sanae, Hitoshi, Kontani, Susumu, Kawashima   +5 more
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A Study of the Relationship between Bile Salts, Bile Salt‐Stimulated Lipase, and Free Fatty Acids in Breast Milk

Journal of Pediatric Gastroenterology and Nutrition, 1990
Summary:Breast milk jaundice has been reported to be associated with increased lipase activity and elevated free fatty acid (FFA) concentrations within breast milk. We have previously shown that bile salts are present in small concentrations in breast milk and the aim of this study was to examine the relationship of bile salt‐stimulated lipase (BSSL ...
J S, Forsyth, L, Donnet, P E, Ross
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Activities and viscosities of aqueous bile acid salt-lecithin solutions

Journal of Solution Chemistry, 1972
Isopiestic and viscosity measurements on aqueous sodium cholate-lecithin solutions are reported at high concentrations which include the physiological region as a lower limit. At low cholate concentration, the addition of lecithin increases the activity of water, consistent with earlier studies showing increases of micellar weights.
E. L. Cussler, C. L. Duncan
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Glucocorticoid treatment alters systemic bile acid homeostasis by regulating the biosynthesis and transport of bile salts

Digestive and Liver Disease, 2016
Dysregulation of systemic bile acid homeostasis can lead to cholestatic liver diseases and metabolic syndromes. As important anti-inflammatory and immunosuppressive drugs, synthetic glucocorticoids (GCs) are used to treat several cholestatic disorders, including biliary atresia (BA), because of their effects on the regulation of bile acid metabolism ...
Yongtao, Xiao, Weihui, Yan, Kejun, Zhou, Yi, Cao, Wei, Cai   +4 more
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Bile salt (glycochenodeoxycholate acid) induces cell survival and chemoresistance in hepatocellular carcinoma

Journal of Cellular Physiology, 2018
AbstractObjectiveGlycochenodeoxycholate acid (GCDA) is a toxic component in bile salts. It plays an important role in the development and progression of liver cancer. In this study, we investigated the underlying mechanism of GCDA in hepatocarcinogenesis and chemotherapy resistance.Materials and MethodsCell proliferation was measured by 3‐(4,5 ...
Chengzhi, Wang, Manyi, Yang, Jinfeng, Zhao, Xia, Li, Xiangcheng, Xiao, Yang, Zhang, Xin, Jin, Mingmei, Liao   +7 more
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Micellar Solubilization of Fatty Acids and Monoglycerides by Bile Salt Solutions

Nature, 1961
BILE salts were recognized as detergents some years ago1, but few investigations have been done on their detergent properties under physiological conditions. Aqueous solutions of detergents are known to form molecular aggregates called micelles2. These form above a critical micellar concentration (CMC) and can solubilize water-insoluble materials ...
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Molecular interactions between selected sodium salts of bile acids and morphine hydrochloride

Colloids and Surfaces B: Biointerfaces, 2012
The objective of this study was to understand the prolonged analgesic action of morphine hydrochloride observed in the presence of sodium 12-oxochenodeoxycholanate. Based on literature, this phenomenon may be due to the formation of aggregates in the cell between the molecules of bile acids and morphine.
Mihalj Poša, János Csanádi, Katalin E. Kövér, Valéria Guzsvány, Gyula Batta   +4 more
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The absorption of bile salt and fatty acid by hamster small intestine

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968
Abstract 1. 1. Hamster intestinal rings were incubated at 37° in a micellar solution containing 2.4 μmoles of sodium taurodeoxycholate, 0.6 pnole of oleic acid, 0.3 μmole of monoolein, and trace amounts of sodium [carboxy-14C]taurodeoxycholate and [9,10-3H2]oleic acid in Krebs-Ringer phosphate buffer (pH 6.3).
S G, Gordon, F, Kern
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