Results 101 to 110 of about 21,588 (329)

Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis

Advanced Science, EarlyView.
Liver fibrosis is a growing global health burden with no specific treatment. HSC activation is the predominant driver of liver fibrogenesis and the current focus in antifibrotic drug discovery. This study identifies autocrine GDF10 activates BMPR2/ALK3‐SMAD1/5/8‐SMAD7 pathway to counteract the TGF‐β‐SMAD2/3 pathway in HSCs, thereby inhibiting HSC ...
Yinliang Zhang, Xiaochen Gai, Yuhui Li, Zuoyu Chen, Xi Zhang, Wei Qiao, Ping Qiu, Chunyuan Du, Sufang Sheng, Jingran Hao, Yujie Zhang, Heng Fan, Xiaorong Li, Ming Liu, Jun Zhang, Zhe Pan, Yongsheng Chang   +16 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

A Case of Adenomyomatous Hyperplasia of the Distal Common Bile Duct Mimicking Malignant Stricture

The Korean Journal of Gastroenterology, 2016
Adenomyomatous hyperplasia is a reactive malformation or non-neoplastic tumor-like lesion frequently observed in the gallbladder, stomach, duodenum and jejunum, but rare in the extrahepatic bile duct.
Jin Ho Choi, Sang Hyub Lee, Joo Seong Kim, Jung Kim, Bang-sup Shin, Dong Kee Jang, Ji Kon Ryu, Yong-Tae Kim   +7 more
doaj   +1 more source

Intrahepatic and extrahepatic intraductal papillary neoplasms of bile duct [PDF]

Korean Journal of Hepato-Biliary-Pancreatic Surgery, 2013
There has been an increase in the number of reported cases of biliary neoplasm of the hepatobiliary system characterized by markedly dilated and multifocal papillary epithelial lesions of the bile ducts or cystic biliary lesions with or without mucin secretion, and mucinous lesions or tumors, possibly due to recent advances in radiological diagnosis ...
openaire   +2 more sources

Generation of a High‐Precision Whole Liver Panorama and Cross‐Scale 3D Pathological Analysis for Hepatic Fibrosis

Advanced Science, EarlyView.
Using the MOSTtechnology and whole‐liver Nissl staining method, a multi‐structural 3D pathological panorama of liver fibrosis is obtained. The damaged sinusoids, steatotic hepatocytes, and collagen deposition are all concentrated in pericentral areas.
Xiaochuan Zhang, Weicheng Yang, Xiaoliang Li, Yanli Zhao, Zongneng Xie, Shuangqu Li, Yue Zeng, Xiaoxu Hao, Xiaohong Xin, Yu Zhang, Zixuan Feng, Hualiang Jiang, Zhaobing Gao, Xianzhen Yin   +13 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Extrahepatic Cholangiocarcinoma in an adult Black Howler Monkey (Primates: Atelidae)

Brazilian Journal of Veterinary Medicine, 2019
Over the past years, the number of neoplasm cases reported in nonhuman primates have considerably increased, with hepatocellular tumors reported in several species.
Mariele de Santi, CAROLINE DO COUTO, GABRIEL LUIZ MONTANHIM, PAOLA CASTRO MORAES, PAULO HENRIQUE LEAL BERTOLO, ROSEMERI DE OLIVEIRA VASCONCELOS, ACÁCIA REBELLO COUTINHO, KARIN WERTHER   +7 more
doaj   +1 more source

Genetic Tracing of Clonal Expansion and Progression of Pancreatic Ductal Adenocarcinoma: A Case Report and Multi-Region Sequencing Analysis

Frontiers in Oncology, 2020
Pancreatobiliary tumors frequently contain multiple malignant and precancerous lesions; however, the origin of the driver mutations and the mechanisms that underlie the generation of distinct clones within an organ field remain unclear.
Shion Tachibana, Shion Tachibana, Shion Tachibana, Yusuke Mizukami, Yusuke Mizukami, Yusuke Ono, Yusuke Ono, Yuya Sugiyama, Yuya Sugiyama, Tetsuhiro Okada, Tetsuhiro Okada, Arisa Kitazaki, Junpei Sasajima, Junpei Sasajima, Motoya Tominaga, Jun Sakamoto, Keisuke Kimura, Yuko Omori, Toru Furukawa, Taichi Kimura, Shinya Tanaka, Kazuo Nagashima, Hidenori Karasaki, Tomoyuki Ohta, Toshikatsu Okumura   +24 more
doaj   +1 more source

Histological insight into the hepatic tissue of the Nile monitor (Varanus niloticus) [PDF]

arXiv, 2018
The liver of reptiles is considered an important study model for the interaction between environment and hepatic tissue. Little is known about the histology of the liver of reptiles. The aim of the current study was to elucidate the histological architecture of the liver of the Nile monitor (Varanus niloticus).
arxiv  

CD8+ T cell memory is sustained in mice by hepatic stellate cells

Hepatology, EarlyView., 2022
HSC role in memory CD8+ T cell maintenance. Abstract Background and Aims Long‐lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8+ cytotoxic T cells (MemCD8TCs) is thought to be mediated by IL‐15/IL‐15R heterodimer (15HD)‐expressing myeloid cells.
Yi‐Ting Chen, Yu‐Chia Su, Yee‐Ern Or, Chin‐Fu Cheng, John T. Kung   +4 more
wiley   +1 more source