Results 111 to 120 of about 60,633 (308)

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Congenital biliary atresia in a Beefmaster calf

Brazilian Journal of Veterinary Pathology, 2016
Biliary atresia is a congenital cholangiopathy characterized by a progressive fibrosis of the bile ducts leading to impaired biliary flow, hepatic failure, icterus and early death.
Johnatan A. Ruíz-Ramírez, Luis J. García-Márquez, Mario A. Bedolla-Alva, Gerardo Salas-Garrido, Rafael Ramírez-Romero, Julio, Alfonso López-Mayagoitia   +6 more
doaj   +1 more source

Percutaneous transhepatic biliary drainage in patients with postsurgical bile leakage and nondilated intrahepatic bile ducts [PDF]

, 2013
Objective and Background: Bile leakage is a serious postoperative complication and percutaneous transhepatic biliary drainage (PTBD) may be an option when endoscopic treatment is not feasible.
Dijk, M. (Monique) van, van Eijck, CHJ, Moelker, Adriaan, Jong, E.A. (Egbert) de, Leertouwer, T, Spronk, S. (Sandra), Spronk, Sandra, de Jong, EA, van Dijk, Monique; id_orcid, Eijck, C.H.J. (Casper) van, Leertouwer, Trude, Moelker, A. (Adriaan), de Jong, Ellen A., Leertouwer, T.C. (Trude), van Dijk, Monique   +14 more
core   +1 more source

Identification of major congenital malformations based on healthcare databases in France: A proof‐of‐concept study using the epi‐meres nationwide mother–child register

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Besides registries, healthcare databases can provide useful information for assessing the frequency of major congenital malformations (MCMs) and investigating their risk factors, particularly medication exposures. This study aimed to assess the validity of MCMs identification based on French national, comprehensive healthcare databases ...
Tom Duchemin, Lise Marty, Jérôme Drouin, Sara Miranda, Jérémie Botton, Valérie Olié, Alain Weill, Rosemary Dray‐Spira   +7 more
wiley   +1 more source

Prevalence and characteristics of gallstone disease in an Iranian population: a study on cadavers [PDF]

BACKGROUND: The prevalence of gallstones is low in Asians. In Iran, many factors influence the prevalence of this disease. The aim of this study was to determine the prevalence of gallbladder stones and their chemical characteristics in a population by ...
شیخ وطن, مهرداد, توفیقی زواره, حسن, قره داغی, جابر, فرزانه, اسماعیل   +3 more
core  

Aberrant subvesical bile ducts identified during laparoscopic cholecystectomy: A rare case report and review of the literature [PDF]

, 2017
Introduction Aberrant subvesical bile ducts are a scarce anatomical variation, consisted by a network of bile ducts located in the peri-hepatic capsule of the gallbladder fossa.
Piperos, T., Zoulamoglou, M., Birbas, K., Mariolis-Sapsakos, T., Papapanagiotou, I., Kaklamanos, I., Mariolis-Sapsakos T., Zarokosta M., Zoulamoglou M., Piperos T., Papapanagiotou I., Sgantzos M., Birbas K., Kaklamanos I., Zarokosta, M., Sgantzos, M.   +8 more
core   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

An Extremely Rare Bile Leakage: Aberrant Bile Duct in Left Triangular Ligament (Appendix Fibrosa Hepatis)

Case Reports in Surgery, 2018
Background. The anatomical variability of bile ducts can leave surgeons in very difficult conditions.Ultrasonography, computed tomography, magnetic resonance imaging (MRCP) and endoscopic imaging methods are used in diagnosis. In addition to conservative
İhsan Yıldız, Yavuz Savaş Koca, Sezayi Kantar   +2 more
doaj   +1 more source

Paucity of Interlobular Bile Ducts in Chinese Children [PDF]

, 2008
　　Sixteen Chinese children with cholestasis since early infancy were diagnosed to have paucity of interlobular bile ducts (PILBD) or its equivalent. Twelve children belonged to the syndromic group of PILBD and four children belonged to the non-syndromic ...
丘秀慧;張美惠;陳志榮;許宏遠;倪衍玄, CHIU, HSIU-HUI;CHANG, MEI-HWEI;CHEN, CHI-LONG;HSU, HONG-YUAN;NI, YEN-HSUAN   +1 more
core  

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source