Results 1 to 10 of about 604 (103)

Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis [PDF]

Cellular and Molecular Biology Letters, 2023
Background The viral G-protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein–Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected cells.
Maša Mavri, Sanja Glisic, Milka Vrecl Fazarinc   +2 more
exaly   +6 more sources

Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality [PDF]

Frontiers in Endocrinology, 2022
Infection of immunosuppressed transplant patients with the human γ-herpesvirus Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD), an often fatal complication.
Maša Mavri, Jianmin Zuo, Milka Vrecl Fazarinc   +2 more
exaly   +4 more sources

Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation [PDF]

MBio, 2019
The Epstein-Barr virus (EBV) BILF1 gene encodes a constitutively active G protein-coupled receptor (GPCR) that downregulates major histocompatibility complex (MHC) class I and induces signaling-dependent tumorigenesis.
Suzan Fares, Emma T B Olesen, Jianmin Zuo   +2 more
exaly   +7 more sources

The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation [PDF]

PLoS Pathogens, 2009
Epstein-Barr virus (EBV) is a human herpesvirus that persists as a largely subclinical infection in the vast majority of adults worldwide. Recent evidence indicates that an important component of the persistence strategy involves active interference with
Jianmin Zuo, Claire Shannon-Lowe, Emmanuel J H J Wiertz   +2 more
exaly   +5 more sources

Methods for Studying Endocytotic Pathways of Herpesvirus Encoded G Protein-Coupled Receptors [PDF]

Molecules, 2020
Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeostasis,
Maša Mavri, Katja Spiess, Mette Marie Rosenkilde, Catrin Sian Rutland, Milka Vrecl, Valentina Kubale   +5 more
doaj   +2 more sources

Functional Implications of Epstein-Barr Virus Lytic Genes in Carcinogenesis. [PDF]

Cancers (Basel), 2022
Epstein-Barr virus (EBV) is associated with a diverse range of tumors of both lymphoid and epithelial origin. Similar to other herpesviruses, EBV displays a bipartite life cycle consisting of latent and lytic phases.
Yap LF, Wong AKC, Paterson IC, Young LS.
europepmc   +4 more sources

HUMAN HERPESVIRUS EPSTEIN-BARR (EBV) AND ITS PORCINE HOMOLOGS UNVEIL THE CONSERVED MECHANISM OF RECEPTOR ENDOCYTOSIS: NEW INSIGHTS INTO VIRAL IMMUNE EVASION AND ANTIVIRAL THERAPY POTENTIAL? [PDF]

Slovenian Veterinary Research
Over the past two years, the University of Ljubljana and the Republic of Slovenia’s public agency, the Slovenian Research and Innovation Service (ARIS), have acknowledged and celebrated several exceptional accomplishments in viral receptor research ...
Valentina Kubale Dvojmoč
doaj   +3 more sources

Porcine Lymphotropic Herpesvirus (PLHV) Was Not Transmitted During Transplantation of Genetically Modified Pig Hearts into Baboons. [PDF]

Int J Mol Sci
Porcine lymphotropic herpesviruses -1, -2, and -3 (PLHV-1, PLHV-2, and PLHV-3) are gammaherpesviruses that are widespread in pigs. These viruses are closely related to the human pathogens Epstein–Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus
Jhelum H, Bender M, Reichart B, Abicht JM, Längin M, Kaufer BB, Denner J.   +6 more
europepmc   +3 more sources

Structural insights into KSHV-GPCR constitutive activation and CXCL1 chemokine recognition. [PDF]

Proc Natl Acad Sci U S A
KSHV-GPCR is a cell surface receptor encoded by the genome of Kaposi's sarcoma-associated herpesvirus that, when expressed in host cells, causes angiogenic tumor of proliferative endothelial cells.
Liu A, Liu Y, Llinàs Del Torrent Masachs C, Zhang W, Pardo L, Ye RD.   +5 more
europepmc   +3 more sources

Viral manipulation of the HLA class I antigen processing and presentation pathway. [PDF]

Front Immunol
Major histocompatibility complex (MHC, human leukocyte antigen [HLA] in humans) class I molecules present peptides at the cell surface to cytotoxic immune cells.
Nolan DS, Altenburg AF.
europepmc   +3 more sources