Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis [PDF]
Cellular & Molecular Biology Letters, 2023 Maša Mavri +6 more
doaj +3 more sources
The Epstein-Barr Virus BILF1 Gene Encodes a G Protein-Coupled Receptor That Inhibits Phosphorylation of RNA-Dependent Protein Kinase [PDF]
Journal of Virology, 2005 Epstein-Barr vires (EBV) infection is associated with many lymphoproliferative diseases, such as infectious mononucleosis and Burkitt's lymphoma. Consequently, EBV is one of the most extensively studied herpesvirases.
Dennis Verzijl +2 more
exaly +9 more sources
Molecular Properties and Therapeutic Targeting of the EBV-Encoded Receptor BILF1 [PDF]
Cancers, 2021 The γ-herpesvirus Epstein–Barr Virus (EBV) establishes lifelong infections in approximately 90% of adults worldwide. Up to 1,000,000 people yearly are estimated to suffer from health conditions attributed to the infection with this virus, such as nasopharyngeal and gastric carcinomas as well as several forms of B, T and NK cell lymphoma.
Julius M Knerr +2 more
exaly +7 more sources
Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1 [PDF]
Immunity, 2021 Epstein-Barr virus (EBV) encodes a G protein-coupled receptor (GPCR) termed BILF1 that is essential for EBV-mediated immunosuppression and oncogenesis. BILF1 couples with inhibitory G protein (Gi), the major intracellular signaling effector for human chemokine receptors, and exhibits constitutive signaling activity; the ligand(s) for BILF1 are unknown.
Naotaka Tsutsumi +2 more
exaly +7 more sources
EBV lytic proteins BZLF1 and BILF1 inhibit the expression of major histocompatibility complex in Raji cells [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate whether BZLF1 and BILF1 can inhibit the expression of major histocompatibility complex(MHC)molecules in Raji cells during Epstein-Barr virus (EBV) lytic cycle.
ZHENG Hongling, GUO Qingwei, ZHANG Wei, ZHANG Yan, HE Xingbo, YE Bing
doaj +2 more sources
Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells [PDF]
Journal of Immunology Research, Volume 2017, Issue 1, 2017., 2017 Immunotoxins as antiviral therapeutics are largely unexplored but have promising prospective due to their high selectivity potential and their unparalleled efficiency.
Jeppesen, Mads G. +5 more
core +6 more sources
Human Herpesviridae Methods of Natural Killer Cell Evasion [PDF]
Advances in Virology, Volume 2012, Issue 1, 2012., 2012 Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from encephalitis to hematologic malignancies. As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection,
Carl I. Odom +3 more
core +3 more sources
Cryo-EM structure of G-protein-coupled receptor GPR17 in complex with inhibitory G protein. [PDF]
MedComm (2020), 2022 GPR17 is a class A orphan G protein‐coupled receptor. The 3.02 Å resolution structure elucidates the activated GPR17 in complex with the Gαi, Gβ, Gγ, and scFv16 in the ligand‐free state. The ECL2 of GPR17 occupies the orthosteric binding pocket to promote its self‐activation. Meanwhile, the residues D350 and E318 of Gαi form two salt bridges with K3318.
Ye F +10 more
europepmc +2 more sources
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation [PDF]
Molecular Cell, 2023 Edward L Huttlin, Benjamin E Gewurz
exaly +2 more sources
Viral G Protein–Coupled Receptors Encoded by β- and γ-Herpesviruses [PDF]
Annual Review of Virology, 2022 Mette Marie Rosenkilde +2 more
exaly +2 more sources